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Q9SIY8

- LAC5_ARATH

UniProt

Q9SIY8 - LAC5_ARATH

Protein

Laccase-5

Gene

LAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Copper 1; type 2By similarity
    Metal bindingi86 – 861Copper 2; type 3By similarity
    Metal bindingi129 – 1291Copper 2; type 3By similarity
    Metal bindingi131 – 1311Copper 3; type 3By similarity
    Metal bindingi481 – 4811Copper 4; type 1By similarity
    Metal bindingi484 – 4841Copper 1; type 2By similarity
    Metal bindingi486 – 4861Copper 3; type 3By similarity
    Metal bindingi543 – 5431Copper 3; type 3By similarity
    Metal bindingi544 – 5441Copper 4; type 1By similarity
    Metal bindingi545 – 5451Copper 2; type 3By similarity
    Metal bindingi549 – 5491Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW
    2. response to copper ion Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G40370-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-5 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 5
    Diphenol oxidase 5
    Urishiol oxidase 5
    Gene namesi
    Name:LAC5
    Synonyms:LAC1
    Ordered Locus Names:At2g40370
    ORF Names:T3G21.14
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G40370.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 580555Laccase-5PRO_0000283633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9SIY8.
    PRIDEiQ9SIY8.

    Expressioni

    Tissue specificityi

    Ubiquitous and constitutive.2 Publications

    Gene expression databases

    GenevestigatoriQ9SIY8.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G40370.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SIY8.
    SMRiQ9SIY8. Positions 23-559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 150117Plastocyanin-like 1Add
    BLAST
    Domaini160 – 312153Plastocyanin-like 2Add
    BLAST
    Domaini428 – 564137Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ9SIY8.
    OMAiCETHNSI.
    PhylomeDBiQ9SIY8.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 4 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9SIY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVTKSLLCF ISFVAFLLFS SVAEANKAHH HEFIIQATKV KRLCETHNSI    50
    TVNGMFPGPM LVVNNGDTLV VKVINRARYN ITIHWHGVRQ MRTGWADGPE 100
    FVTQCPIRPG SSYTYRFTIQ GQEGTLWWHA HSSWLRATVY GSLLVFPPAG 150
    SSYPFTKPHR NVPLLLGEWW DANPVDVLRE SIRTGGAPNN SDAYTINGQP 200
    GDLYKCSSQD TTVVPINVGE TILLRVINSA LNQPLFFTVA NHKLTVVGAD 250
    ASYLKPFTTN VIVLGPGQTT DVLITGDQPP NRYYMAARAY QSAQNAPFGN 300
    TTTTAILQYK SAPCCGVGGG SGTKKGNSFK PIMPILPAYN DTNTVTRFSQ 350
    SFRSLRRAEV PTEIDENLFV TIGLGLNNCP KNFRSRRCQG PNGTRFTASM 400
    NNVSFALPSN YSLLQAHHHG IPGVFTTDFP AKPPVKFDYT GNNISRSLYQ 450
    PDRGTKLYKL KYGSRVQIVL QDTGIVTPEN HPIHLHGYDF YIIAEGFGNF 500
    NPKKDTAKFN LEDPPLRNTV GVPVNGWAVI RFIADNPGVW IMHCHLDAHI 550
    SWGLAMAFLV ENGNGVLQTI EQPPHDLPVC 580
    Length:580
    Mass (Da):64,133
    Last modified:May 1, 2000 - v1
    Checksum:iEFD565D79AD887CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506030 mRNA. Translation: AAM77221.1.
    AC007020 Genomic DNA. Translation: AAD25671.1.
    CP002685 Genomic DNA. Translation: AEC09819.1.
    PIRiF84828.
    RefSeqiNP_181568.1. NM_129597.3.
    UniGeneiAt.37061.

    Genome annotation databases

    EnsemblPlantsiAT2G40370.1; AT2G40370.1; AT2G40370.
    GeneIDi818630.
    KEGGiath:AT2G40370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506030 mRNA. Translation: AAM77221.1 .
    AC007020 Genomic DNA. Translation: AAD25671.1 .
    CP002685 Genomic DNA. Translation: AEC09819.1 .
    PIRi F84828.
    RefSeqi NP_181568.1. NM_129597.3.
    UniGenei At.37061.

    3D structure databases

    ProteinModelPortali Q9SIY8.
    SMRi Q9SIY8. Positions 23-559.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G40370.1-P.

    Proteomic databases

    PaxDbi Q9SIY8.
    PRIDEi Q9SIY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G40370.1 ; AT2G40370.1 ; AT2G40370 .
    GeneIDi 818630.
    KEGGi ath:AT2G40370.

    Organism-specific databases

    TAIRi AT2G40370.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q9SIY8.
    OMAi CETHNSI.
    PhylomeDBi Q9SIY8.

    Enzyme and pathway databases

    BioCyci ARA:AT2G40370-MONOMER.

    Gene expression databases

    Genevestigatori Q9SIY8.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 4 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, characterization, and expression of a cDNA clone encoding laccase from Arabidopsis thaliana."
      Gaynor J.J.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
      McCaig B.C., Meagher R.B., Dean J.F.D.
      Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC5_ARATH
    AccessioniPrimary (citable) accession number: Q9SIY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3