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Q9SIY8

- LAC5_ARATH

UniProt

Q9SIY8 - LAC5_ARATH

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Protein
Laccase-5
Gene
LAC5, LAC1, At2g40370, T3G21.14
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Copper 1; type 2 By similarity
Metal bindingi86 – 861Copper 2; type 3 By similarity
Metal bindingi129 – 1291Copper 2; type 3 By similarity
Metal bindingi131 – 1311Copper 3; type 3 By similarity
Metal bindingi481 – 4811Copper 4; type 1 By similarity
Metal bindingi484 – 4841Copper 1; type 2 By similarity
Metal bindingi486 – 4861Copper 3; type 3 By similarity
Metal bindingi543 – 5431Copper 3; type 3 By similarity
Metal bindingi544 – 5441Copper 4; type 1 By similarity
Metal bindingi545 – 5451Copper 2; type 3 By similarity
Metal bindingi549 – 5491Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
  2. response to copper ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G40370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-5 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 5
Diphenol oxidase 5
Urishiol oxidase 5
Gene namesi
Name:LAC5
Synonyms:LAC1
Ordered Locus Names:At2g40370
ORF Names:T3G21.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G40370.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 580555Laccase-5
PRO_0000283633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SIY8.
PRIDEiQ9SIY8.

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Gene expression databases

GenevestigatoriQ9SIY8.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40370.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SIY8.
SMRiQ9SIY8. Positions 23-559.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 150117Plastocyanin-like 1
Add
BLAST
Domaini160 – 312153Plastocyanin-like 2
Add
BLAST
Domaini428 – 564137Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9SIY8.
OMAiCETHNSI.
PhylomeDBiQ9SIY8.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SIY8-1 [UniParc]FASTAAdd to Basket

« Hide

MDVTKSLLCF ISFVAFLLFS SVAEANKAHH HEFIIQATKV KRLCETHNSI    50
TVNGMFPGPM LVVNNGDTLV VKVINRARYN ITIHWHGVRQ MRTGWADGPE 100
FVTQCPIRPG SSYTYRFTIQ GQEGTLWWHA HSSWLRATVY GSLLVFPPAG 150
SSYPFTKPHR NVPLLLGEWW DANPVDVLRE SIRTGGAPNN SDAYTINGQP 200
GDLYKCSSQD TTVVPINVGE TILLRVINSA LNQPLFFTVA NHKLTVVGAD 250
ASYLKPFTTN VIVLGPGQTT DVLITGDQPP NRYYMAARAY QSAQNAPFGN 300
TTTTAILQYK SAPCCGVGGG SGTKKGNSFK PIMPILPAYN DTNTVTRFSQ 350
SFRSLRRAEV PTEIDENLFV TIGLGLNNCP KNFRSRRCQG PNGTRFTASM 400
NNVSFALPSN YSLLQAHHHG IPGVFTTDFP AKPPVKFDYT GNNISRSLYQ 450
PDRGTKLYKL KYGSRVQIVL QDTGIVTPEN HPIHLHGYDF YIIAEGFGNF 500
NPKKDTAKFN LEDPPLRNTV GVPVNGWAVI RFIADNPGVW IMHCHLDAHI 550
SWGLAMAFLV ENGNGVLQTI EQPPHDLPVC 580
Length:580
Mass (Da):64,133
Last modified:May 1, 2000 - v1
Checksum:iEFD565D79AD887CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506030 mRNA. Translation: AAM77221.1.
AC007020 Genomic DNA. Translation: AAD25671.1.
CP002685 Genomic DNA. Translation: AEC09819.1.
PIRiF84828.
RefSeqiNP_181568.1. NM_129597.3.
UniGeneiAt.37061.

Genome annotation databases

EnsemblPlantsiAT2G40370.1; AT2G40370.1; AT2G40370.
GeneIDi818630.
KEGGiath:AT2G40370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF506030 mRNA. Translation: AAM77221.1 .
AC007020 Genomic DNA. Translation: AAD25671.1 .
CP002685 Genomic DNA. Translation: AEC09819.1 .
PIRi F84828.
RefSeqi NP_181568.1. NM_129597.3.
UniGenei At.37061.

3D structure databases

ProteinModelPortali Q9SIY8.
SMRi Q9SIY8. Positions 23-559.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT2G40370.1-P.

Proteomic databases

PaxDbi Q9SIY8.
PRIDEi Q9SIY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G40370.1 ; AT2G40370.1 ; AT2G40370 .
GeneIDi 818630.
KEGGi ath:AT2G40370.

Organism-specific databases

TAIRi AT2G40370.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9SIY8.
OMAi CETHNSI.
PhylomeDBi Q9SIY8.

Enzyme and pathway databases

BioCyci ARA:AT2G40370-MONOMER.

Gene expression databases

Genevestigatori Q9SIY8.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization, and expression of a cDNA clone encoding laccase from Arabidopsis thaliana."
    Gaynor J.J.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC5_ARATH
AccessioniPrimary (citable) accession number: Q9SIY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi