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Protein

Laccase-5

Gene

LAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1; type 2By similarity1
Metal bindingi86Copper 2; type 3By similarity1
Metal bindingi129Copper 2; type 3By similarity1
Metal bindingi131Copper 3; type 3By similarity1
Metal bindingi481Copper 4; type 1By similarity1
Metal bindingi484Copper 1; type 2By similarity1
Metal bindingi486Copper 3; type 3By similarity1
Metal bindingi543Copper 3; type 3By similarity1
Metal bindingi544Copper 4; type 1By similarity1
Metal bindingi545Copper 2; type 3By similarity1
Metal bindingi549Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • lignin catabolic process Source: UniProtKB-KW
  • response to copper ion Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G40370-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-5 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 5
Diphenol oxidase 5
Urishiol oxidase 5
Gene namesi
Name:LAC5
Synonyms:LAC1
Ordered Locus Names:At2g40370
ORF Names:T3G21.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G40370
TAIRilocus:2063109 AT2G40370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028363326 – 580Laccase-5Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SIY8

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Gene expression databases

ExpressionAtlasiQ9SIY8 baseline and differential
GenevisibleiQ9SIY8 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40370.1

Structurei

3D structure databases

ProteinModelPortaliQ9SIY8
SMRiQ9SIY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150Plastocyanin-like 1Add BLAST117
Domaini160 – 312Plastocyanin-like 2Add BLAST153
Domaini428 – 564Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ9SIY8
KOiK05909
OMAiCLVYSCA
OrthoDBiEOG093605O6
PhylomeDBiQ9SIY8

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 4 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SIY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVTKSLLCF ISFVAFLLFS SVAEANKAHH HEFIIQATKV KRLCETHNSI
60 70 80 90 100
TVNGMFPGPM LVVNNGDTLV VKVINRARYN ITIHWHGVRQ MRTGWADGPE
110 120 130 140 150
FVTQCPIRPG SSYTYRFTIQ GQEGTLWWHA HSSWLRATVY GSLLVFPPAG
160 170 180 190 200
SSYPFTKPHR NVPLLLGEWW DANPVDVLRE SIRTGGAPNN SDAYTINGQP
210 220 230 240 250
GDLYKCSSQD TTVVPINVGE TILLRVINSA LNQPLFFTVA NHKLTVVGAD
260 270 280 290 300
ASYLKPFTTN VIVLGPGQTT DVLITGDQPP NRYYMAARAY QSAQNAPFGN
310 320 330 340 350
TTTTAILQYK SAPCCGVGGG SGTKKGNSFK PIMPILPAYN DTNTVTRFSQ
360 370 380 390 400
SFRSLRRAEV PTEIDENLFV TIGLGLNNCP KNFRSRRCQG PNGTRFTASM
410 420 430 440 450
NNVSFALPSN YSLLQAHHHG IPGVFTTDFP AKPPVKFDYT GNNISRSLYQ
460 470 480 490 500
PDRGTKLYKL KYGSRVQIVL QDTGIVTPEN HPIHLHGYDF YIIAEGFGNF
510 520 530 540 550
NPKKDTAKFN LEDPPLRNTV GVPVNGWAVI RFIADNPGVW IMHCHLDAHI
560 570 580
SWGLAMAFLV ENGNGVLQTI EQPPHDLPVC
Length:580
Mass (Da):64,133
Last modified:May 1, 2000 - v1
Checksum:iEFD565D79AD887CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506030 mRNA Translation: AAM77221.1
AC007020 Genomic DNA Translation: AAD25671.1
CP002685 Genomic DNA Translation: AEC09819.1
PIRiF84828
RefSeqiNP_181568.1, NM_129597.4
UniGeneiAt.37061

Genome annotation databases

EnsemblPlantsiAT2G40370.1; AT2G40370.1; AT2G40370
GeneIDi818630
GrameneiAT2G40370.1; AT2G40370.1; AT2G40370
KEGGiath:AT2G40370

Similar proteinsi

Entry informationi

Entry nameiLAC5_ARATH
AccessioniPrimary (citable) accession number: Q9SIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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