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Protein

Laccase-5

Gene

LAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1; type 2By similarity1
Metal bindingi86Copper 2; type 3By similarity1
Metal bindingi129Copper 2; type 3By similarity1
Metal bindingi131Copper 3; type 3By similarity1
Metal bindingi481Copper 4; type 1By similarity1
Metal bindingi484Copper 1; type 2By similarity1
Metal bindingi486Copper 3; type 3By similarity1
Metal bindingi543Copper 3; type 3By similarity1
Metal bindingi544Copper 4; type 1By similarity1
Metal bindingi545Copper 2; type 3By similarity1
Metal bindingi549Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • lignin catabolic process Source: UniProtKB-KW
  • response to copper ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G40370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-5 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 5
Diphenol oxidase 5
Urishiol oxidase 5
Gene namesi
Name:LAC5
Synonyms:LAC1
Ordered Locus Names:At2g40370
ORF Names:T3G21.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G40370.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028363326 – 580Laccase-5Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Glycosylationi410N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SIY8.

Expressioni

Tissue specificityi

Ubiquitous and constitutive.2 Publications

Gene expression databases

GenevisibleiQ9SIY8. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40370.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SIY8.
SMRiQ9SIY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150Plastocyanin-like 1Add BLAST117
Domaini160 – 312Plastocyanin-like 2Add BLAST153
Domaini428 – 564Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9SIY8.
KOiK05909.
OMAiKSAPCCG.
OrthoDBiEOG093605O6.
PhylomeDBiQ9SIY8.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SIY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVTKSLLCF ISFVAFLLFS SVAEANKAHH HEFIIQATKV KRLCETHNSI
60 70 80 90 100
TVNGMFPGPM LVVNNGDTLV VKVINRARYN ITIHWHGVRQ MRTGWADGPE
110 120 130 140 150
FVTQCPIRPG SSYTYRFTIQ GQEGTLWWHA HSSWLRATVY GSLLVFPPAG
160 170 180 190 200
SSYPFTKPHR NVPLLLGEWW DANPVDVLRE SIRTGGAPNN SDAYTINGQP
210 220 230 240 250
GDLYKCSSQD TTVVPINVGE TILLRVINSA LNQPLFFTVA NHKLTVVGAD
260 270 280 290 300
ASYLKPFTTN VIVLGPGQTT DVLITGDQPP NRYYMAARAY QSAQNAPFGN
310 320 330 340 350
TTTTAILQYK SAPCCGVGGG SGTKKGNSFK PIMPILPAYN DTNTVTRFSQ
360 370 380 390 400
SFRSLRRAEV PTEIDENLFV TIGLGLNNCP KNFRSRRCQG PNGTRFTASM
410 420 430 440 450
NNVSFALPSN YSLLQAHHHG IPGVFTTDFP AKPPVKFDYT GNNISRSLYQ
460 470 480 490 500
PDRGTKLYKL KYGSRVQIVL QDTGIVTPEN HPIHLHGYDF YIIAEGFGNF
510 520 530 540 550
NPKKDTAKFN LEDPPLRNTV GVPVNGWAVI RFIADNPGVW IMHCHLDAHI
560 570 580
SWGLAMAFLV ENGNGVLQTI EQPPHDLPVC
Length:580
Mass (Da):64,133
Last modified:May 1, 2000 - v1
Checksum:iEFD565D79AD887CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506030 mRNA. Translation: AAM77221.1.
AC007020 Genomic DNA. Translation: AAD25671.1.
CP002685 Genomic DNA. Translation: AEC09819.1.
PIRiF84828.
RefSeqiNP_181568.1. NM_129597.4.
UniGeneiAt.37061.

Genome annotation databases

EnsemblPlantsiAT2G40370.1; AT2G40370.1; AT2G40370.
GeneIDi818630.
GrameneiAT2G40370.1; AT2G40370.1; AT2G40370.
KEGGiath:AT2G40370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506030 mRNA. Translation: AAM77221.1.
AC007020 Genomic DNA. Translation: AAD25671.1.
CP002685 Genomic DNA. Translation: AEC09819.1.
PIRiF84828.
RefSeqiNP_181568.1. NM_129597.4.
UniGeneiAt.37061.

3D structure databases

ProteinModelPortaliQ9SIY8.
SMRiQ9SIY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G40370.1.

Proteomic databases

PaxDbiQ9SIY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G40370.1; AT2G40370.1; AT2G40370.
GeneIDi818630.
GrameneiAT2G40370.1; AT2G40370.1; AT2G40370.
KEGGiath:AT2G40370.

Organism-specific databases

TAIRiAT2G40370.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9SIY8.
KOiK05909.
OMAiKSAPCCG.
OrthoDBiEOG093605O6.
PhylomeDBiQ9SIY8.

Enzyme and pathway databases

BioCyciARA:AT2G40370-MONOMER.

Miscellaneous databases

PROiQ9SIY8.

Gene expression databases

GenevisibleiQ9SIY8. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC5_ARATH
AccessioniPrimary (citable) accession number: Q9SIY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.