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Protein

Presenilin-like protein At2g29900

Gene

At2g29900

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei198By similarity1
Active sitei318By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiA22.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin-like protein At2g29900
Gene namesi
Ordered Locus Names:At2g29900
ORF Names:F6K5.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29900.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 76LumenalSequence analysisAdd BLAST38
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 106CytoplasmicSequence analysis9
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 135LumenalSequence analysis8
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 158CytoplasmicSequence analysis2
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 188LumenalSequence analysis9
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 305CytoplasmicSequence analysisAdd BLAST96
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336LumenalSequence analysis10
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 366CytoplasmicSequence analysis9
Intramembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 397CytoplasmicSequence analysis10

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi-associated vesicle Source: TAIR
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: TAIR
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739061 – 397Presenilin-like protein At2g29900Add BLAST397

Proteomic databases

PaxDbiQ9SIK7.

PTM databases

iPTMnetiQ9SIK7.

Expressioni

Gene expression databases

GenevisibleiQ9SIK7. AT.

Interactioni

Subunit structurei

Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, APH1 and PEN2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi2890. 2 interactors.
STRINGi3702.AT2G29900.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SIK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi363 – 365PAL3

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
HOGENOMiHOG000240228.
InParanoidiQ9SIK7.
KOiK04505.
OMAiSICMFTV.
OrthoDBiEOG09360DOM.
PhylomeDBiQ9SIK7.

Family and domain databases

InterProiIPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SIK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRNQRPRSI LDSLGEELIA ILTPVSICMF TVVLLVCILN SDPSSSSASF
60 70 80 90 100
SSIATAAYSE SDSDSSWDKF VGALLNSVVF VAAITVATFV LVLLFYLRCV
110 120 130 140 150
KFLKFYMGFS AFIVLGNLGG EILVLLIDRF RFPIDSITFL ILLFNFSVVG
160 170 180 190 200
VFAVFMSKFS ILITQGYLVW IGVLVAYFFT LLPEWTTWVL LVALALYDIA
210 220 230 240 250
AVLLPVGPLR LLVEMAISRD EDIPALVYEA RPVIRNDSRS VQRRVWREQR
260 270 280 290 300
SSQNNANRNE VRVVESAEVE EEHVGSSERA EISVPLIDRR PEQAENSETF
310 320 330 340 350
LEGIGLGSSG AIKLGLGDFI FYSVLVGRAA MYDLMTVYAC YLAIIAGLGI
360 370 380 390
TLMLLSVYQK ALPALPVSIM LGVVFYFLAR LLLEVFVVQC SSNLVMF
Length:397
Mass (Da):44,012
Last modified:May 1, 2000 - v1
Checksum:iDE6804D6CA186783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007113 Genomic DNA. Translation: AAD23630.1.
CP002685 Genomic DNA. Translation: AEC08318.1.
BT028914 mRNA. Translation: ABI49461.1.
PIRiA84702.
RefSeqiNP_180551.1. NM_128544.4.
UniGeneiAt.66277.

Genome annotation databases

EnsemblPlantsiAT2G29900.1; AT2G29900.1; AT2G29900.
GeneIDi817540.
GrameneiAT2G29900.1; AT2G29900.1; AT2G29900.
KEGGiath:AT2G29900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007113 Genomic DNA. Translation: AAD23630.1.
CP002685 Genomic DNA. Translation: AEC08318.1.
BT028914 mRNA. Translation: ABI49461.1.
PIRiA84702.
RefSeqiNP_180551.1. NM_128544.4.
UniGeneiAt.66277.

3D structure databases

ProteinModelPortaliQ9SIK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2890. 2 interactors.
STRINGi3702.AT2G29900.1.

Protein family/group databases

MEROPSiA22.A02.

PTM databases

iPTMnetiQ9SIK7.

Proteomic databases

PaxDbiQ9SIK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29900.1; AT2G29900.1; AT2G29900.
GeneIDi817540.
GrameneiAT2G29900.1; AT2G29900.1; AT2G29900.
KEGGiath:AT2G29900.

Organism-specific databases

TAIRiAT2G29900.

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
HOGENOMiHOG000240228.
InParanoidiQ9SIK7.
KOiK04505.
OMAiSICMFTV.
OrthoDBiEOG09360DOM.
PhylomeDBiQ9SIK7.

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9SIK7.

Gene expression databases

GenevisibleiQ9SIK7. AT.

Family and domain databases

InterProiIPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PfamiPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSNB_ARATH
AccessioniPrimary (citable) accession number: Q9SIK7
Secondary accession number(s): Q0IGK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.