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Protein

B-box zinc finger protein 25

Gene

BBX25

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109). BBX25/STH and BBX24/STO function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression. BBX25/STH acts additively with BBX24/STO during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 47B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri57 – 99B box-type 2; atypicalPROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

  • negative regulation of photomorphogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-box zinc finger protein 251 Publication
Alternative name(s):
Protein SALT TOLERANCE HOMOLOG 1
Salt tolerance-like protein
Gene namesi
Name:BBX251 Publication
Synonyms:STH, STH1
Ordered Locus Names:At2g31380
ORF Names:T28P16.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRilocus:2061330. AT2G31380.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced length of hypocotyls.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20D → A: Abolishes interaction with HY5. 1 Publication1
Mutagenesisi72D → A: Abolishes interaction with HY5. 1 Publication1
Mutagenesisi234 – 235VP → AA: Abolishes interaction with COP1. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132961 – 238B-box zinc finger protein 25Add BLAST238

Post-translational modificationi

COP1-mediated ubiquitination and subsequent proteasomal degradation of BBX25/STH occurs in the dark.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9SID1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SID1. baseline and differential.
GenevisibleiQ9SID1. AT.

Interactioni

Subunit structurei

Interacts with COP1 WD40 domain (PubMed:11226162). Interacts with HY5 (PubMed:23624715) and HYH (PubMed:23733077).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COP1P432543EBI-631960,EBI-301649

Protein-protein interaction databases

BioGridi3043. 3 interactors.
IntActiQ9SID1. 1 interactor.
STRINGi3702.AT2G31380.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SID1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni226 – 238Interaction with COP11 PublicationAdd BLAST13

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 47B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri57 – 99B box-type 2; atypicalPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFJB. Eukaryota.
ENOG410YBMW. LUCA.
HOGENOMiHOG000239240.
InParanoidiQ9SID1.
OMAiNTRSANH.
OrthoDBiEOG09360M9M.
PhylomeDBiQ9SID1.

Family and domain databases

InterProiView protein in InterPro
IPR000315. Znf_B-box.
PfamiView protein in Pfam
PF00643. zf-B_box. 2 hits.
SMARTiView protein in SMART
SM00336. BBOX. 2 hits.
PROSITEiView protein in PROSITE
PS50119. ZF_BBOX. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9SID1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIQCDVCEK APATLICCAD EAALCAKCDV EVHAANKLAS KHQRLFLDSL
60 70 80 90 100
STKFPPCDIC LEKAAFIFCV EDRALLCRDC DEATHAPNTR SANHQRFLAT
110 120 130 140 150
GIRVALSSTS CNQEVEKNHF DPSNQQSLSK PPTQQPAAPS PLWATDEFFS
160 170 180 190 200
YSDLDCSNKE KEQLDLGELD WLAEMGLFGD QPDQEALPVA EVPELSFSHL
210 220 230
AHAHSYNRPM KSNVPNKKQR LEYRYDDEEE HFLVPDLG
Length:238
Mass (Da):26,657
Last modified:December 5, 2001 - v2
Checksum:i1088617F55A003AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323666 mRNA. Translation: AAK01658.1.
AC007169 Genomic DNA. Translation: AAD26481.2.
CP002685 Genomic DNA. Translation: AEC08540.1.
AF325077 mRNA. Translation: AAK17145.1.
AF370311 mRNA. Translation: AAK44126.1.
AY063097 mRNA. Translation: AAL34271.1.
PIRiA84720.
RefSeqiNP_565722.1. NM_128695.4.
UniGeneiAt.24192.
At.69838.

Genome annotation databases

EnsemblPlantsiAT2G31380.1; AT2G31380.1; AT2G31380.
GeneIDi817696.
GrameneiAT2G31380.1; AT2G31380.1; AT2G31380.
KEGGiath:AT2G31380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323666 mRNA. Translation: AAK01658.1.
AC007169 Genomic DNA. Translation: AAD26481.2.
CP002685 Genomic DNA. Translation: AEC08540.1.
AF325077 mRNA. Translation: AAK17145.1.
AF370311 mRNA. Translation: AAK44126.1.
AY063097 mRNA. Translation: AAL34271.1.
PIRiA84720.
RefSeqiNP_565722.1. NM_128695.4.
UniGeneiAt.24192.
At.69838.

3D structure databases

ProteinModelPortaliQ9SID1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3043. 3 interactors.
IntActiQ9SID1. 1 interactor.
STRINGi3702.AT2G31380.1.

Proteomic databases

PaxDbiQ9SID1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G31380.1; AT2G31380.1; AT2G31380.
GeneIDi817696.
GrameneiAT2G31380.1; AT2G31380.1; AT2G31380.
KEGGiath:AT2G31380.

Organism-specific databases

AraportiAT2G31380.
TAIRilocus:2061330. AT2G31380.

Phylogenomic databases

eggNOGiENOG410IFJB. Eukaryota.
ENOG410YBMW. LUCA.
HOGENOMiHOG000239240.
InParanoidiQ9SID1.
OMAiNTRSANH.
OrthoDBiEOG09360M9M.
PhylomeDBiQ9SID1.

Miscellaneous databases

PROiQ9SID1.

Gene expression databases

ExpressionAtlasiQ9SID1. baseline and differential.
GenevisibleiQ9SID1. AT.

Family and domain databases

InterProiView protein in InterPro
IPR000315. Znf_B-box.
PfamiView protein in Pfam
PF00643. zf-B_box. 2 hits.
SMARTiView protein in SMART
SM00336. BBOX. 2 hits.
PROSITEiView protein in PROSITE
PS50119. ZF_BBOX. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBBX25_ARATH
AccessioniPrimary (citable) accession number: Q9SID1
Secondary accession number(s): Q9C558
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: February 15, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.