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Protein

3-ketoacyl-CoA synthase 12

Gene

KCS12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.Curated

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168By similarity1
Active sitei247By similarity1
Active sitei344By similarity1
Active sitei348By similarity1
Active sitei377By similarity1
Active sitei381By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciARA:AT2G28630-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA synthase 121 Publication (EC:2.3.1.199Curated)
Short name:
KCS-121 Publication
Alternative name(s):
Very long-chain fatty acid condensing enzyme 121 Publication
Short name:
VLCFA condensing enzyme 121 Publication
Gene namesi
Name:KCS121 Publication
Ordered Locus Names:At2g28630Imported
ORF Names:T8O18.8Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G28630
TAIRilocus:2065499 AT2G28630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000024910426 – 4763-ketoacyl-CoA synthase 12Add BLAST451

Proteomic databases

PaxDbiQ9SIB2

Expressioni

Tissue specificityi

Expressed in siliques, flowers and leaves.1 Publication

Inductioni

Repressed by herbicides such as flufenacet and benfuresate (PubMed:12916765). Up-regulated by osmotic stress and down-regulated by low temperature, salt and drought (PubMed:18465198).2 Publications

Gene expression databases

ExpressionAtlasiQ9SIB2 baseline and differential
GenevisibleiQ9SIB2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G28630.1

Structurei

3D structure databases

ProteinModelPortaliQ9SIB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 313FAESequence analysisAdd BLAST288

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH8S Eukaryota
ENOG410Y9JS LUCA
HOGENOMiHOG000238893
InParanoidiQ9SIB2
KOiK15397
OMAiEGPKIDF
OrthoDBiEOG093608SJ
PhylomeDBiQ9SIB2

Family and domain databases

InterProiView protein in InterPro
IPR012392 3-ktacl-CoA_syn
IPR013747 ACP_syn_III_C
IPR013601 FAE1_typ3_polyketide_synth
IPR016039 Thiolase-like
PANTHERiPTHR31561 PTHR31561, 1 hit
PfamiView protein in Pfam
PF08541 ACP_syn_III_C, 1 hit
PF08392 FAE1_CUT1_RppA, 1 hit
PIRSFiPIRSF036417 3-ktacl-CoA_syn, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SIB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLFLFFSL LLSYLFFKIW KLIDSKQDKD CYILDYQCHK PTDDRMVSTQ
60 70 80 90 100
FSGEIIYRNQ NLGLTEYKFL LKAIVSSGIG EQTYAPRLVF EGREERPSLQ
110 120 130 140 150
DGISEMEEFY VDSIGKLLER NQISPKDIDI LVVNVSMLSS TPSLASRIIN
160 170 180 190 200
HYKMRDDVKV FNLTGMGCSA SLISVDIVKN IFKSYANKLA LVATSESLSP
210 220 230 240 250
NWYSGNNRSM ILANCLFRSG GCAILLTNKR SLRKKAMFKL KCMVRTHHGA
260 270 280 290 300
REESYNCCIQ AEDEQGRVGF YLGKNLPKAA TRAFVENLKV ITPKILPVTE
310 320 330 340 350
LIRFMLKLLI KKIKIRQNPS KGSTNLPPGT PLKAGINFKT GIEHFCIHTG
360 370 380 390 400
GKAVIDGIGH SLDLNEYDIE PARMTLHRFG NTSASSLWYV LAYMEAKKRL
410 420 430 440 450
KRGDRVFMIS FGAGFKCNSC VWEVVRDLTG GESKGNVWNH CIDDYPPKSI
460 470
LNPYLEKFGW IQDEDPDTFK VPDAFM
Length:476
Mass (Da):53,974
Last modified:May 1, 2000 - v1
Checksum:i04C9124611E75D87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286E → D in AAM61290 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007171 Genomic DNA Translation: AAD24372.1
CP002685 Genomic DNA Translation: AEC08152.1
CP002685 Genomic DNA Translation: ANM62747.1
AY056170 mRNA Translation: AAL07019.1
AY091195 mRNA Translation: AAM14134.1
AY084716 mRNA Translation: AAM61290.1
PIRiC84687
RefSeqiNP_001318305.1, NM_001336183.1
NP_180431.1, NM_128424.3
UniGeneiAt.26366

Genome annotation databases

EnsemblPlantsiAT2G28630.1; AT2G28630.1; AT2G28630
AT2G28630.2; AT2G28630.2; AT2G28630
GeneIDi817412
GrameneiAT2G28630.1; AT2G28630.1; AT2G28630
AT2G28630.2; AT2G28630.2; AT2G28630
KEGGiath:AT2G28630

Similar proteinsi

Entry informationi

Entry nameiKCS12_ARATH
AccessioniPrimary (citable) accession number: Q9SIB2
Secondary accession number(s): Q8LFQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health