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Protein

Arginine decarboxylase 1

Gene

ADC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine (PubMed:11576438, PubMed:15733873, PubMed:25409942). Is a minor contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis (PubMed:25409942). Accumulation of putrescine plays a positive role in freezing tolerance (PubMed:18701673). Production of polyamines is essential for normal seed development (PubMed:15733873). Controls PA homeostasis which is crucial for normal plant growth and development (PubMed:27014322).5 Publications

Catalytic activityi

L-arginine = agmatine + CO2.1 Publication

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase 2 (ADC2), Arginine decarboxylase (AXX17_At4g39700), Arginine decarboxylase (AXX17_At2g11570), Arginine decarboxylase 1 (ADC1)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • arginine decarboxylase activity Source: UniProtKB-EC
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • arginine catabolic process Source: InterPro
  • polyamine biosynthetic process Source: TAIR
  • putrescine biosynthetic process Source: UniProtKB-KW
  • response to cold Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to salt stress Source: TAIR
  • spermidine biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPutrescine biosynthesis, Spermidine biosynthesis, Stress response
LigandMagnesium, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G16500-MONOMER
BRENDAi4.1.1.19 399
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase 1Curated (EC:4.1.1.191 Publication)
Short name:
ADC 1Curated
Short name:
ADC-OCurated
Short name:
ARGDC 1Curated
Short name:
AtADC11 Publication
Gene namesi
Name:ADC11 Publication
Synonyms:SPE11 Publication
Ordered Locus Names:At2g16500Imported
ORF Names:F1P15.12Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G16500
TAIRilocus:2045111 AT2G16500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Cytoplasm, Plastid

Pathology & Biotechi

Disruption phenotypei

Increased levels of lateral root branching.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136K → A: Loss of decarboxylase activity. 1 Publication1
Mutagenesisi524C → A: Loss of decarboxylase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499461 – 702Arginine decarboxylase 1Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9SI64

Expressioni

Inductioni

Induced by freezing (PubMed:18701673). Induced by the bacterial pathogen Pseudomonas viridiflava (PubMed:25409942).2 Publications

Gene expression databases

ExpressionAtlasiQ9SI64 baseline and differential
GenevisibleiQ9SI64 AT

Interactioni

Subunit structurei

Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers. May form a head-to-tail homodimer (PubMed:11576438). Homodimer and heterodimer with ADC2 (PubMed:28109885).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi3702.AT2G16500.1

Structurei

3D structure databases

ProteinModelPortaliQ9SI64
SMRiQ9SI64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 330Substrate-bindingBy similarityAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKSU Eukaryota
COG1166 LUCA
HOGENOMiHOG000029191
InParanoidiQ9SI64
KOiK01583
OMAiTRAVMGQ
OrthoDBiEOG09360480
PhylomeDBiQ9SI64

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SI64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALAFVDTP IDTFSSIFTP SSVSTAVVDG SCHWSPSLSS SLYRIDGWGA
60 70 80 90 100
PYFAANSSGN ISVRPHGSNT LPHQDIDLMK VVKKVTDPSG LGLQLPLIVR
110 120 130 140 150
FPDVLKNRLE CLQSAFDYAI QSQGYDSHYQ GVYPVKCNQD RFIIEDIVEF
160 170 180 190 200
GSGFRFGLEA GSKPEILLAM SCLCKGNPEA FLVCNGFKDS EYISLALFGR
210 220 230 240 250
KLELNTVIVL EQEEELDLVI DLSQKMNVRP VIGLRAKLRT KHSGHFGSTS
260 270 280 290 300
GEKGKFGLTT VQILRVVRKL SQVGMLDCLQ LLHFHIGSQI PSTALLSDGV
310 320 330 340 350
AEAAQLYCEL VRLGAHMKVI DIGGGLGIDY DGSKSGESDL SVAYSLEEYA
360 370 380 390 400
AAVVASVRFV CDQKSVKHPV ICSESGRAIV SHHSVLIFEA VSAGQQHETP
410 420 430 440 450
TDHQFMLEGY SEEVRGDYEN LYGAAMRGDR ESCLLYVDQL KQRCVEGFKE
460 470 480 490 500
GSLGIEQLAG VDGLCEWVIK AIGASDPVLT YHVNLSVFTS IPDFWGIDQL
510 520 530 540 550
FPIVPIHKLD QRPAARGILS DLTCDSDGKI NKFIGGESSL PLHEMDNNGC
560 570 580 590 600
SGGRYYLGMF LGGAYEEALG GVHNLFGGPS VVRVLQSDGP HGFAVTRAVM
610 620 630 640 650
GQSSADVLRA MQHEPELMFQ TLKHRAEEPR NNNNKACGDK GNDKLVVASC
660 670 680 690 700
LAKSFNNMPY LSMETSTNAL TAAVNNLGVY YCDEAAAGGG GKGKDENWSY

FG
Length:702
Mass (Da):76,175
Last modified:May 1, 2000 - v1
Checksum:i8B9D182B2684BCA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti452S → F in AAB09723 (PubMed:8756495).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52851 mRNA Translation: AAB09723.1
AC007195 Genomic DNA Translation: AAD26494.1
CP002685 Genomic DNA Translation: AEC06503.1
BT008636 mRNA Translation: AAP40453.1
PIRiA84541
S71239
RefSeqiNP_179243.1, NM_127204.3
UniGeneiAt.10173

Genome annotation databases

EnsemblPlantsiAT2G16500.1; AT2G16500.1; AT2G16500
GeneIDi816149
GrameneiAT2G16500.1; AT2G16500.1; AT2G16500
KEGGiath:AT2G16500

Similar proteinsi

Entry informationi

Entry nameiSPE1_ARATH
AccessioniPrimary (citable) accession number: Q9SI64
Secondary accession number(s): Q38938
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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