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Protein

Arginine decarboxylase 1

Gene

SPE1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathway: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase 2 (SPE2), Arginine decarboxylase 1 (SPE1)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • arginine catabolic process Source: InterPro
  • putrescine biosynthetic process from arginine Source: GO_Central
  • response to cold Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to salt stress Source: TAIR
  • spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G16500-MONOMER.
BRENDAi4.1.1.19. 399.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase 1 (EC:4.1.1.19)
Short name:
ADC 1
Short name:
ADC-O
Short name:
ARGDC 1
Gene namesi
Name:SPE1
Ordered Locus Names:At2g16500
ORF Names:F1P15.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G16500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Arginine decarboxylase 1PRO_0000149946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ9SI64.
PRIDEiQ9SI64.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G16500.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SI64.
SMRiQ9SI64. Positions 43-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 33011Substrate-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiQ9SI64.
KOiK01583.
OMAiCEWVIKA.
PhylomeDBiQ9SI64.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SI64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALAFVDTP IDTFSSIFTP SSVSTAVVDG SCHWSPSLSS SLYRIDGWGA
60 70 80 90 100
PYFAANSSGN ISVRPHGSNT LPHQDIDLMK VVKKVTDPSG LGLQLPLIVR
110 120 130 140 150
FPDVLKNRLE CLQSAFDYAI QSQGYDSHYQ GVYPVKCNQD RFIIEDIVEF
160 170 180 190 200
GSGFRFGLEA GSKPEILLAM SCLCKGNPEA FLVCNGFKDS EYISLALFGR
210 220 230 240 250
KLELNTVIVL EQEEELDLVI DLSQKMNVRP VIGLRAKLRT KHSGHFGSTS
260 270 280 290 300
GEKGKFGLTT VQILRVVRKL SQVGMLDCLQ LLHFHIGSQI PSTALLSDGV
310 320 330 340 350
AEAAQLYCEL VRLGAHMKVI DIGGGLGIDY DGSKSGESDL SVAYSLEEYA
360 370 380 390 400
AAVVASVRFV CDQKSVKHPV ICSESGRAIV SHHSVLIFEA VSAGQQHETP
410 420 430 440 450
TDHQFMLEGY SEEVRGDYEN LYGAAMRGDR ESCLLYVDQL KQRCVEGFKE
460 470 480 490 500
GSLGIEQLAG VDGLCEWVIK AIGASDPVLT YHVNLSVFTS IPDFWGIDQL
510 520 530 540 550
FPIVPIHKLD QRPAARGILS DLTCDSDGKI NKFIGGESSL PLHEMDNNGC
560 570 580 590 600
SGGRYYLGMF LGGAYEEALG GVHNLFGGPS VVRVLQSDGP HGFAVTRAVM
610 620 630 640 650
GQSSADVLRA MQHEPELMFQ TLKHRAEEPR NNNNKACGDK GNDKLVVASC
660 670 680 690 700
LAKSFNNMPY LSMETSTNAL TAAVNNLGVY YCDEAAAGGG GKGKDENWSY

FG
Length:702
Mass (Da):76,175
Last modified:May 1, 2000 - v1
Checksum:i8B9D182B2684BCA0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521S → F in AAB09723 (PubMed:8756495).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52851 mRNA. Translation: AAB09723.1.
AC007195 Genomic DNA. Translation: AAD26494.1.
CP002685 Genomic DNA. Translation: AEC06503.1.
BT008636 mRNA. Translation: AAP40453.1.
PIRiA84541.
S71239.
RefSeqiNP_179243.1. NM_127204.2.
UniGeneiAt.10173.

Genome annotation databases

EnsemblPlantsiAT2G16500.1; AT2G16500.1; AT2G16500.
GeneIDi816149.
KEGGiath:AT2G16500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52851 mRNA. Translation: AAB09723.1.
AC007195 Genomic DNA. Translation: AAD26494.1.
CP002685 Genomic DNA. Translation: AEC06503.1.
BT008636 mRNA. Translation: AAP40453.1.
PIRiA84541.
S71239.
RefSeqiNP_179243.1. NM_127204.2.
UniGeneiAt.10173.

3D structure databases

ProteinModelPortaliQ9SI64.
SMRiQ9SI64. Positions 43-628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G16500.1.

Proteomic databases

PaxDbiQ9SI64.
PRIDEiQ9SI64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G16500.1; AT2G16500.1; AT2G16500.
GeneIDi816149.
KEGGiath:AT2G16500.

Organism-specific databases

TAIRiAT2G16500.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiQ9SI64.
KOiK01583.
OMAiCEWVIKA.
PhylomeDBiQ9SI64.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciARA:AT2G16500-MONOMER.
BRENDAi4.1.1.19. 399.

Miscellaneous databases

PROiQ9SI64.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of Arabidopsis thaliana (L.) Heynh Arginine decarboxylase by potassium deficiency stress."
    Watson M.B., Malmberg R.L.
    Plant Physiol. 111:1077-1083(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiSPE1_ARATH
AccessioniPrimary (citable) accession number: Q9SI64
Secondary accession number(s): Q38938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.