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Protein

Glutathione S-transferase U24

Gene

GSTU24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione binding Source: TAIR
  • glutathione transferase activity Source: TAIR

GO - Biological processi

  • 2,4,6-trinitrotoluene catabolic process Source: TAIR
  • glutathione metabolic process Source: GO_Central
  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT1G17170-MONOMER.
MetaCyc:AT1G17170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U24 (EC:2.5.1.18)
Short name:
AtGSTU24
Alternative name(s):
GST class-tau member 24
Gene namesi
Name:GSTU24
Ordered Locus Names:At1g17170
ORF Names:F20D23.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17170.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 218217Glutathione S-transferase U24PRO_0000413569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SHH6.
PRIDEiQ9SHH6.

Expressioni

Inductioni

By acetochlor, metolachlor, 2,4,6-trinitrotoluene (TNT) and 2,6-dinitrotoluene (2,6-DNT).2 Publications

Gene expression databases

GenevisibleiQ9SHH6. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G17170.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SHH6.
SMRiQ9SHH6. Positions 1-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8280GST N-terminalAdd
BLAST
Domaini88 – 215128GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 142Glutathione bindingBy similarity
Regioni39 – 402Glutathione bindingBy similarity
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9SHH6.
KOiK00799.
OMAiCSKLIAW.
OrthoDBiEOG09360PCQ.
PhylomeDBiQ9SHH6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SHH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEVILLDF WASMFGMRTR IALAEKRVKY DHREEDLWNK SSLLLEMNPV
60 70 80 90 100
HKKIPVLIHN GKPVCESLIQ IEYIDETWPD NNPLLPSDPY KRAHAKFWAD
110 120 130 140 150
FIDKKVNVTA RRIWAVKGEE QEAAKELIEI LKTLESELGD KKYFGDETFG
160 170 180 190 200
YVDIALIGFH SWFAVYEKFG NVSIESECSK LVAWAKRCLE RESVAKALPE
210
SEKVITFISE RRKKLGLE
Length:218
Mass (Da):25,306
Last modified:May 1, 2000 - v1
Checksum:iAEC9508B1A776560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007651 Genomic DNA. Translation: AAD50016.1.
CP002684 Genomic DNA. Translation: AEE29554.1.
BT012184 mRNA. Translation: AAS76278.1.
PIRiG86307.
RefSeqiNP_173160.1. NM_101578.2.
UniGeneiAt.41850.

Genome annotation databases

EnsemblPlantsiAT1G17170.1; AT1G17170.1; AT1G17170.
GeneIDi838288.
GrameneiAT1G17170.1; AT1G17170.1; AT1G17170.
KEGGiath:AT1G17170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007651 Genomic DNA. Translation: AAD50016.1.
CP002684 Genomic DNA. Translation: AEE29554.1.
BT012184 mRNA. Translation: AAS76278.1.
PIRiG86307.
RefSeqiNP_173160.1. NM_101578.2.
UniGeneiAt.41850.

3D structure databases

ProteinModelPortaliQ9SHH6.
SMRiQ9SHH6. Positions 1-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G17170.1.

Proteomic databases

PaxDbiQ9SHH6.
PRIDEiQ9SHH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17170.1; AT1G17170.1; AT1G17170.
GeneIDi838288.
GrameneiAT1G17170.1; AT1G17170.1; AT1G17170.
KEGGiath:AT1G17170.

Organism-specific databases

TAIRiAT1G17170.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9SHH6.
KOiK00799.
OMAiCSKLIAW.
OrthoDBiEOG09360PCQ.
PhylomeDBiQ9SHH6.

Enzyme and pathway databases

BioCyciARA:AT1G17170-MONOMER.
MetaCyc:AT1G17170-MONOMER.

Miscellaneous databases

PROiQ9SHH6.

Gene expression databases

GenevisibleiQ9SHH6. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTUO_ARATH
AccessioniPrimary (citable) accession number: Q9SHH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.