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Q9SHH6 (GSTUO_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase U24

Short name=AtGSTU24
EC=2.5.1.18
Alternative name(s):
GST class-tau member 24
Gene names
Name:GSTU24
Ordered Locus Names:At1g17170
ORF Names:F20D23.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Cytoplasmcytosol Probable.

Induction

By acetochlor, metolachlor, 2,4,6-trinitrotoluene (TNT) and 2,6-dinitrotoluene (2,6-DNT). Ref.5 Ref.6

Sequence similarities

Belongs to the GST superfamily. Tau family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Biological processDetoxification
Stress response
   Cellular componentCytoplasm
   Molecular functionTransferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

response to toxic substance

Inferred from electronic annotation. Source: UniProtKB-KW

toxin catabolic process

Traceable author statement Ref.4. Source: TAIR

   Cellular_componentcytoplasm

Non-traceable author statement Ref.4. Source: TAIR

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione binding

Inferred from direct assay PubMed 15159623. Source: TAIR

glutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 218217Glutathione S-transferase U24
PRO_0000413569

Regions

Domain3 – 8280GST N-terminal
Domain88 – 215128GST C-terminal
Region13 – 142Glutathione binding By similarity
Region39 – 402Glutathione binding By similarity
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Amino acid modifications

Modified residue1481Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9SHH6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: AEC9508B1A776560

FASTA21825,306
        10         20         30         40         50         60 
MADEVILLDF WASMFGMRTR IALAEKRVKY DHREEDLWNK SSLLLEMNPV HKKIPVLIHN 

        70         80         90        100        110        120 
GKPVCESLIQ IEYIDETWPD NNPLLPSDPY KRAHAKFWAD FIDKKVNVTA RRIWAVKGEE 

       130        140        150        160        170        180 
QEAAKELIEI LKTLESELGD KKYFGDETFG YVDIALIGFH SWFAVYEKFG NVSIESECSK 

       190        200        210 
LVAWAKRCLE RESVAKALPE SEKVITFISE RRKKLGLE 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Kim C.J., Chen H., Cheuk R.F., Shinn P., Carninci P., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M., Shinozaki K., Ecker J.R.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
Wagner U., Edwards R., Dixon D.P., Mauch F.
Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Gene expression and microscopic analysis of Arabidopsis exposed to chloroacetanilide herbicides and explosive compounds. A phytoremediation approach."
Mezzari M.P., Walters K., Jelinkova M., Shih M.C., Just C.L., Schnoor J.L.
Plant Physiol. 138:858-869(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"Phytotoxicity and phytoremediation of 2,6-dinitrotoluene using a model plant, Arabidopsis thaliana."
Yoon J.M., Oliver D.J., Shanks J.V.
Chemosphere 68:1050-1057(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC007651 Genomic DNA. Translation: AAD50016.1.
CP002684 Genomic DNA. Translation: AEE29554.1.
BT012184 mRNA. Translation: AAS76278.1.
PIRG86307.
RefSeqNP_173160.1. NM_101578.2.
UniGeneAt.41850.

3D structure databases

ProteinModelPortalQ9SHH6.
SMRQ9SHH6. Positions 1-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G17170.1-P.

Proteomic databases

PaxDbQ9SHH6.
PRIDEQ9SHH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G17170.1; AT1G17170.1; AT1G17170.
GeneID838288.
KEGGath:AT1G17170.

Organism-specific databases

TAIRAT1G17170.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125749.
InParanoidQ9SHH6.
KOK00799.
OMAVTARRIW.
PhylomeDBQ9SHH6.
ProtClustDBCLSN2914422.

Enzyme and pathway databases

BioCycARA:AT1G17170-MONOMER.
MetaCyc:AT1G17170-MONOMER.

Gene expression databases

GenevestigatorQ9SHH6.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTUO_ARATH
AccessionPrimary (citable) accession number: Q9SHH6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names