ID   TPS3_ARATH              Reviewed;         783 AA.
AC   Q9SHG0; F4I628;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 3.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 3;
DE            EC=2.4.1.15;
DE   AltName: Full=Trehalose-6-phosphate synthase 3;
DE            Short=AtTPS3;
GN   Name=TPS3; OrderedLocusNames=At1g17000; ORFNames=F20D23.30;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11701378; DOI=10.1016/s1360-1385(01)02125-2;
RA   Leyman B., Van Dijck P., Thevelein J.M.;
RT   "An unexpected plethora of trehalose biosynthesis genes in Arabidopsis
RT   thaliana.";
RL   Trends Plant Sci. 6:510-513(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC         trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC   -!- SIMILARITY: In the N-terminal section; belongs to the
CC       glycosyltransferase 20 family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the trehalose
CC       phosphatase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD50035.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC007651; AAD50035.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE29529.1; -; Genomic_DNA.
DR   PIR; F86305; F86305.
DR   RefSeq; NP_173143.4; NM_101560.5.
DR   AlphaFoldDB; Q9SHG0; -.
DR   SMR; Q9SHG0; -.
DR   STRING; 3702.Q9SHG0; -.
DR   CAZy; GT20; Glycosyltransferase Family 20.
DR   PaxDb; 3702-AT1G17000-1; -.
DR   ProteomicsDB; 228383; -.
DR   GeneID; 838270; -.
DR   KEGG; ath:AT1G17000; -.
DR   Araport; AT1G17000; -.
DR   TAIR; AT1G17000; -.
DR   eggNOG; KOG1050; Eukaryota.
DR   HOGENOM; CLU_358125_0_0_1; -.
DR   InParanoid; Q9SHG0; -.
DR   OrthoDB; 1023at2759; -.
DR   PRO; PR:Q9SHG0; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SHG0; baseline and differential.
DR   GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IBA:GO_Central.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0070413; P:trehalose metabolism in response to stress; IBA:GO_Central.
DR   CDD; cd03788; GT20_TPS; 1.
DR   CDD; cd01627; HAD_TPP; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR001830; Glyco_trans_20.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR003337; Trehalose_PPase.
DR   PANTHER; PTHR10788:SF83; ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 3-RELATED; 1.
DR   PANTHER; PTHR10788; TREHALOSE-6-PHOSPHATE SYNTHASE; 1.
DR   Pfam; PF00982; Glyco_transf_20; 1.
DR   Pfam; PF02358; Trehalose_PPase; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   Genevisible; Q9SHG0; AT.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..783
FT                   /note="Probable alpha,alpha-trehalose-phosphate synthase
FT                   [UDP-forming] 3"
FT                   /id="PRO_0000324824"
FT   REGION          11..456
FT                   /note="Glycosyltransferase"
SQ   SEQUENCE   783 AA;  89483 MW;  262F05A09098887E CRC64;
     MGYDNVCGER QTLLVVANRL PASAKRTGEH SWSLEMSPGG KFNLLVEKDA VSKSLAEMKC
     IPVFLNEVFD QYYNGYSNGI LWPILHHMGL PQEYDHDTIK TFETQYDAYK KANRMFLDVI
     KENYKDGDIV WCQDYHLMFL PQYLKEYNNK IKVGWFLHSP FPSSEIYKTL PSRSELLRSV
     LAADLISFHT YDFARHFVNT CTRILGVEGT HEGVVYQGRV TRVVVLPMGI YPNRFIKTCK
     LPEVIQQMNE LKDRFSGKKV ILGVDRLDMI KGIPQKYLGF EKFLDENPNW RDKIVLVQIA
     VPTRNEVPEY QKLKNQVHRL VGRINGRFGS VSSLPIHHMD CSVDSNYLCA LYAISDVMLV
     TSLRDGLNLV SHEFVACQEA KRGVLILSEF AGAGQSLGAG ALLVNPWNVT EVSSAIKKAL
     NMPYEERETR HRVNFKYVKT HSAEKWGFDF LSELNDAFDE SELQIRKIPH ELPQQDVIQR
     YSLSNNRLII LGFYGTITEP RNSLSKEMDL KLNPELKETL KALCNDPKTT VVVLSRSGKN
     ILDKNFGEYK IWLAAENGMF LKHTTEEWVT NMPQNMNLDW VDGLKNVFKY FTDRTPRSFF
     EASKTSLVWN YEYADVEFGR AQARDLLQYL WAGPISNASA EVVRGKYSVE VHAIGVTKEP
     EIGHILGEIV HKKAMTTPID YVFCSGYFLE KDEDIYTFFE SEILSPKLSH ETRSKSSSSN
     HSLEKKVSLN VLDLKQENYF STAIGQARTK ARYVVDSSHN VVNLLHKLAV ANTTTTSVKK
     PNV
//