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UniProtKB - Q9SH76 (PMA6_ARATH)

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Protein

ATPase 6, plasma membrane-type

Gene

AHA6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).By similarity

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3324-aspartylphosphate intermediateBy similarity1
Metal bindingi590MagnesiumBy similarity1
Metal bindingi594MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G07560-MONOMER.

Protein family/group databases

TCDBi3.A.3.3.8. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 6, plasma membrane-type (EC:3.6.3.6)
Alternative name(s):
Proton pump 6
Gene namesi
Name:AHA6
Ordered Locus Names:At2g07560
ORF Names:F9A16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRilocus:2053343. AT2G07560.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
Transmembranei65 – 84Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini85 – 96ExtracellularSequence analysisAdd BLAST12
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 246CytoplasmicSequence analysisAdd BLAST129
Transmembranei247 – 267Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini268 – 276ExtracellularSequence analysis9
Transmembranei277 – 294Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini295 – 645CytoplasmicSequence analysisAdd BLAST351
Transmembranei646 – 667Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini668 – 672ExtracellularSequence analysis5
Transmembranei673 – 695Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini696 – 711CytoplasmicSequence analysisAdd BLAST16
Transmembranei712 – 732Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini733 – 753ExtracellularSequence analysisAdd BLAST21
Transmembranei754 – 774Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini775 – 786CytoplasmicSequence analysisAdd BLAST12
Transmembranei787 – 807Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini808 – 815ExtracellularSequence analysis8
Transmembranei816 – 836Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini837 – 949CytoplasmicSequence analysisAdd BLAST113

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462791 – 949ATPase 6, plasma membrane-typeAdd BLAST949

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei883PhosphothreonineBy similarity1
Modified residuei931PhosphoserineBy similarity1
Modified residuei948PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SH76.
PRIDEiQ9SH76.

PTM databases

iPTMnetiQ9SH76.

Expressioni

Gene expression databases

GenevisibleiQ9SH76. AT.

Interactioni

Subunit structurei

Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-948. Binding to 14-3-3 proteins activates the H+-ATPase (By similarity).By similarity

Protein-protein interaction databases

BioGridi719. 1 interactor.
IntActiQ9SH76. 1 interactor.
STRINGi3702.AT2G07560.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SH76.
SMRiQ9SH76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni947 – 949Interaction with 14-3-3 proteinsBy similarity3

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ9SH76.
KOiK01535.
OMAiRWEEQDA.
OrthoDBiEOG093602AD.
PhylomeDBiQ9SH76.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADISWDEI KKENVDLEKI PVDEVFQQLK CSREGLSSEE GRNRLQIFGA 
        60         70         80         90        100
NKLEEKVENK FLKFLGFMWN PLSWVMEAAA IMAIVLANGG GRPPDWQDFV 
       110        120        130        140        150
GITCLLIINS TISFIEENNA GNAAAALMAN LAPKTKVLRD GRWGEQEAAI 
       160        170        180        190        200
LVPGDLISIK LGDIVPADAR LLEGDPLKID QSALTGESLP ATKHQGDEVF 
       210        220        230        240        250
SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTNNVGHFQ KVLTAIGNFC 
       260        270        280        290        300
ICSIGIGMLI EIIIMYPIQH RKYRDGIDNL LVLLIGGIPI AMPTVLSVTM 
       310        320        330        340        350
AIGSHRLSQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLTVDKNLIE 
       360        370        380        390        400
VFSKDVDKDY VILLSARASR VENQDAIDTS IVNMLGDPKE ARAGITEVHF 
       410        420        430        440        450
LPFNPVEKRT AITYIDTNGE WHRCSKGAPE QIIELCDLKG ETKRRAHEII 
       460        470        480        490        500
DKFAERGLRS LGVARQRVPE KDKESAGTPW EFVGLLPLFD PPRHDSAETI 
       510        520        530        540        550
RRALDLGVNV KMITGDQLAI GKETGRRLGM GTNMYPSSSL LENKDDTTGG 
       560        570        580        590        600
VPVDELIEKA DGFAGVFPEH KYEIVRKLQE RKHIVGMTGD GVNDAPALKK 
       610        620        630        640        650
ADIGIAVDDA TDAARSASDI VLTEPGLSVI VSAVLTSRAI FQRMKNYTIY 
       660        670        680        690        700
AVSITIRIVL GFMLVALIWE FDFSPFMVLI IAILNDGTIM TISKDRVKPS 
       710        720        730        740        750
PIPDSWKLKE IFATGVVLGT YMALVTVVFF WLAHDTTFFS DKFGVRSLQG 
       760        770        780        790        800
KDEELIAVLY LQVSIISQAL IFVTRSRSWS FVERPGLLLL IAFFVAQLIA 
       810        820        830        840        850
TLIATYAHWE FARIKGCGWG WCGVIWIYSI VTYIPLDILK FITRYTLSGK 
       860        870        880        890        900
AWNNMIENRT AFTTKKDYGR GEREAQWALA QRTLHGLKPP ESMFEDTATY 
       910        920        930        940 
TELSEIAEQA KKRAEVARLR EVHTLKGHVE SVVKLKGLDI DNLNQHYTV
Length:949
Mass (Da):105,012
Last modified:May 1, 2000 - v1
Checksum:i25C076607DB214EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007662 Genomic DNA. Translation: AAD32758.1.
CP002685 Genomic DNA. Translation: AEC06056.1.
BT002855 mRNA. Translation: AAO22672.1.
PIRiG84486.
RefSeqiNP_178762.1. NM_126721.3.
UniGeneiAt.40955.

Genome annotation databases

EnsemblPlantsiAT2G07560.1; AT2G07560.1; AT2G07560.
GeneIDi815329.
GrameneiAT2G07560.1; AT2G07560.1; AT2G07560.
KEGGiath:AT2G07560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007662 Genomic DNA. Translation: AAD32758.1.
CP002685 Genomic DNA. Translation: AEC06056.1.
BT002855 mRNA. Translation: AAO22672.1.
PIRiG84486.
RefSeqiNP_178762.1. NM_126721.3.
UniGeneiAt.40955.

3D structure databases

ProteinModelPortaliQ9SH76.
SMRiQ9SH76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi719. 1 interactor.
IntActiQ9SH76. 1 interactor.
STRINGi3702.AT2G07560.1.

Protein family/group databases

TCDBi3.A.3.3.8. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiQ9SH76.

Proteomic databases

PaxDbiQ9SH76.
PRIDEiQ9SH76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G07560.1; AT2G07560.1; AT2G07560.
GeneIDi815329.
GrameneiAT2G07560.1; AT2G07560.1; AT2G07560.
KEGGiath:AT2G07560.

Organism-specific databases

AraportiAT2G07560.
TAIRilocus:2053343. AT2G07560.

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ9SH76.
KOiK01535.
OMAiRWEEQDA.
OrthoDBiEOG093602AD.
PhylomeDBiQ9SH76.

Enzyme and pathway databases

BioCyciARA:AT2G07560-MONOMER.

Miscellaneous databases

PROiPR:Q9SH76.

Gene expression databases

GenevisibleiQ9SH76. AT.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMA6_ARATH
AccessioniPrimary (citable) accession number: Q9SH76
Secondary accession number(s): Q84WR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.