UniProtKB - Q9SH76 (PMA6_ARATH)
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Protein
ATPase 6, plasma membrane-type
Gene
AHA6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).By similarity
Catalytic activityi
ATP + H2O + H+(In) = ADP + phosphate + H+(Out).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 332 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 590 | MagnesiumBy similarity | 1 | |
Metal bindingi | 594 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: UniProtKB-EC
GO - Biological processi
- proton export across plasma membrane Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT2G07560-MONOMER. |
Protein family/group databases
TCDBi | 3.A.3.3.8. the p-type atpase (p-atpase) superfamily. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AHA6 Ordered Locus Names:At2g07560 ORF Names:F9A16.7 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G07560. |
TAIRi | locus:2053343. AT2G07560. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 64 | CytoplasmicSequence analysisAdd BLAST | 64 | |
Transmembranei | 65 – 84 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 85 – 96 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 97 – 117 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 246 | CytoplasmicSequence analysisAdd BLAST | 129 | |
Transmembranei | 247 – 267 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 276 | ExtracellularSequence analysis | 9 | |
Transmembranei | 277 – 294 | Helical; Name=4Sequence analysisAdd BLAST | 18 | |
Topological domaini | 295 – 645 | CytoplasmicSequence analysisAdd BLAST | 351 | |
Transmembranei | 646 – 667 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 668 – 672 | ExtracellularSequence analysis | 5 | |
Transmembranei | 673 – 695 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 696 – 711 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 712 – 732 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 733 – 753 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 754 – 774 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 775 – 786 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 787 – 807 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 808 – 815 | ExtracellularSequence analysis | 8 | |
Transmembranei | 816 – 836 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 837 – 949 | CytoplasmicSequence analysisAdd BLAST | 113 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046279 | 1 – 949 | ATPase 6, plasma membrane-typeAdd BLAST | 949 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 883 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 931 | PhosphoserineBy similarity | 1 | |
Modified residuei | 948 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9SH76. |
PRIDEi | Q9SH76. |
PTM databases
iPTMneti | Q9SH76. |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SH76. baseline and differential. |
Genevisiblei | Q9SH76. AT. |
Interactioni
Subunit structurei
Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-948. Binding to 14-3-3 proteins activates the H+-ATPase (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 719. 1 interactor. |
IntActi | Q9SH76. 1 interactor. |
STRINGi | 3702.AT2G07560.1. |
Structurei
3D structure databases
ProteinModelPortali | Q9SH76. |
SMRi | Q9SH76. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 947 – 949 | Interaction with 14-3-3 proteinsBy similarity | 3 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0205. Eukaryota. COG0474. LUCA. |
HOGENOMi | HOG000160005. |
InParanoidi | Q9SH76. |
KOi | K01535. |
OMAi | RWEEQDA. |
OrthoDBi | EOG093602AD. |
PhylomeDBi | Q9SH76. |
Family and domain databases
CDDi | cd02076. P-type_ATPase_H. 1 hit. |
Gene3Di | 3.40.1110.10. 1 hit. |
InterProi | View protein in InterPro IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_dom_N. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom_sf. IPR008250. ATPase_P-typ_transduc_dom_A_sf. IPR036412. HAD-like_sf. IPR006534. P-type_ATPase_IIIA. IPR001757. P_typ_ATPase. |
Pfami | View protein in Pfam PF00690. Cation_ATPase_N. 1 hit. |
PRINTSi | PR00120. HATPASE. |
SMARTi | View protein in SMART SM00831. Cation_ATPase_N. 1 hit. |
SUPFAMi | SSF56784. SSF56784. 2 hits. SSF81653. SSF81653. 1 hit. SSF81665. SSF81665. 3 hits. |
TIGRFAMsi | TIGR01647. ATPase-IIIA_H. 1 hit. TIGR01494. ATPase_P-type. 2 hits. |
PROSITEi | View protein in PROSITE PS00154. ATPASE_E1_E2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9SH76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAADISWDEI KKENVDLEKI PVDEVFQQLK CSREGLSSEE GRNRLQIFGA
60 70 80 90 100
NKLEEKVENK FLKFLGFMWN PLSWVMEAAA IMAIVLANGG GRPPDWQDFV
110 120 130 140 150
GITCLLIINS TISFIEENNA GNAAAALMAN LAPKTKVLRD GRWGEQEAAI
160 170 180 190 200
LVPGDLISIK LGDIVPADAR LLEGDPLKID QSALTGESLP ATKHQGDEVF
210 220 230 240 250
SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTNNVGHFQ KVLTAIGNFC
260 270 280 290 300
ICSIGIGMLI EIIIMYPIQH RKYRDGIDNL LVLLIGGIPI AMPTVLSVTM
310 320 330 340 350
AIGSHRLSQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLTVDKNLIE
360 370 380 390 400
VFSKDVDKDY VILLSARASR VENQDAIDTS IVNMLGDPKE ARAGITEVHF
410 420 430 440 450
LPFNPVEKRT AITYIDTNGE WHRCSKGAPE QIIELCDLKG ETKRRAHEII
460 470 480 490 500
DKFAERGLRS LGVARQRVPE KDKESAGTPW EFVGLLPLFD PPRHDSAETI
510 520 530 540 550
RRALDLGVNV KMITGDQLAI GKETGRRLGM GTNMYPSSSL LENKDDTTGG
560 570 580 590 600
VPVDELIEKA DGFAGVFPEH KYEIVRKLQE RKHIVGMTGD GVNDAPALKK
610 620 630 640 650
ADIGIAVDDA TDAARSASDI VLTEPGLSVI VSAVLTSRAI FQRMKNYTIY
660 670 680 690 700
AVSITIRIVL GFMLVALIWE FDFSPFMVLI IAILNDGTIM TISKDRVKPS
710 720 730 740 750
PIPDSWKLKE IFATGVVLGT YMALVTVVFF WLAHDTTFFS DKFGVRSLQG
760 770 780 790 800
KDEELIAVLY LQVSIISQAL IFVTRSRSWS FVERPGLLLL IAFFVAQLIA
810 820 830 840 850
TLIATYAHWE FARIKGCGWG WCGVIWIYSI VTYIPLDILK FITRYTLSGK
860 870 880 890 900
AWNNMIENRT AFTTKKDYGR GEREAQWALA QRTLHGLKPP ESMFEDTATY
910 920 930 940
TELSEIAEQA KKRAEVARLR EVHTLKGHVE SVVKLKGLDI DNLNQHYTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007662 Genomic DNA. Translation: AAD32758.1. CP002685 Genomic DNA. Translation: AEC06056.1. BT002855 mRNA. Translation: AAO22672.1. |
PIRi | G84486. |
RefSeqi | NP_178762.1. NM_126721.3. |
UniGenei | At.40955. |
Genome annotation databases
EnsemblPlantsi | AT2G07560.1; AT2G07560.1; AT2G07560. |
GeneIDi | 815329. |
Gramenei | AT2G07560.1; AT2G07560.1; AT2G07560. |
KEGGi | ath:AT2G07560. |
Similar proteinsi
Entry informationi
Entry namei | PMA6_ARATH | |
Accessioni | Q9SH76Primary (citable) accession number: Q9SH76 Secondary accession number(s): Q84WR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |