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Protein

ATPase 6, plasma membrane-type

Gene

AHA6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).By similarity

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei332 – 33214-aspartylphosphate intermediateBy similarity
Metal bindingi590 – 5901MagnesiumBy similarity
Metal bindingi594 – 5941MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G07560-MONOMER.

Protein family/group databases

TCDBi3.A.3.3.8. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 6, plasma membrane-type (EC:3.6.3.6)
Alternative name(s):
Proton pump 6
Gene namesi
Name:AHA6
Ordered Locus Names:At2g07560
ORF Names:F9A16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G07560.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8420Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini85 – 9612ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini118 – 246129CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini268 – 2769ExtracellularSequence analysis
Transmembranei277 – 29418Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini295 – 645351CytoplasmicSequence analysisAdd
BLAST
Transmembranei646 – 66722Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini668 – 6725ExtracellularSequence analysis
Transmembranei673 – 69523Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini696 – 71116CytoplasmicSequence analysisAdd
BLAST
Transmembranei712 – 73221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini733 – 75321ExtracellularSequence analysisAdd
BLAST
Transmembranei754 – 77421Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini775 – 78612CytoplasmicSequence analysisAdd
BLAST
Transmembranei787 – 80721Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini808 – 8158ExtracellularSequence analysis
Transmembranei816 – 83621Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini837 – 949113CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949ATPase 6, plasma membrane-typePRO_0000046279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei883 – 8831PhosphothreonineBy similarity
Modified residuei931 – 9311PhosphoserineBy similarity
Modified residuei948 – 9481PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SH76.
PRIDEiQ9SH76.

PTM databases

iPTMnetiQ9SH76.

Expressioni

Gene expression databases

GenevisibleiQ9SH76. AT.

Interactioni

Subunit structurei

Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-948. Binding to 14-3-3 proteins activates the H+-ATPase (By similarity).By similarity

Protein-protein interaction databases

BioGridi719. 1 interaction.
IntActiQ9SH76. 1 interaction.
STRINGi3702.AT2G07560.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SH76.
SMRiQ9SH76. Positions 15-845, 920-949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni947 – 9493Interaction with 14-3-3 proteinsBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ9SH76.
KOiK01535.
OMAiNTITENR.
OrthoDBiEOG093602AD.
PhylomeDBiQ9SH76.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADISWDEI KKENVDLEKI PVDEVFQQLK CSREGLSSEE GRNRLQIFGA
60 70 80 90 100
NKLEEKVENK FLKFLGFMWN PLSWVMEAAA IMAIVLANGG GRPPDWQDFV
110 120 130 140 150
GITCLLIINS TISFIEENNA GNAAAALMAN LAPKTKVLRD GRWGEQEAAI
160 170 180 190 200
LVPGDLISIK LGDIVPADAR LLEGDPLKID QSALTGESLP ATKHQGDEVF
210 220 230 240 250
SGSTCKQGEI EAVVIATGVH TFFGKAAHLV DSTNNVGHFQ KVLTAIGNFC
260 270 280 290 300
ICSIGIGMLI EIIIMYPIQH RKYRDGIDNL LVLLIGGIPI AMPTVLSVTM
310 320 330 340 350
AIGSHRLSQQ GAITKRMTAI EEMAGMDVLC SDKTGTLTLN KLTVDKNLIE
360 370 380 390 400
VFSKDVDKDY VILLSARASR VENQDAIDTS IVNMLGDPKE ARAGITEVHF
410 420 430 440 450
LPFNPVEKRT AITYIDTNGE WHRCSKGAPE QIIELCDLKG ETKRRAHEII
460 470 480 490 500
DKFAERGLRS LGVARQRVPE KDKESAGTPW EFVGLLPLFD PPRHDSAETI
510 520 530 540 550
RRALDLGVNV KMITGDQLAI GKETGRRLGM GTNMYPSSSL LENKDDTTGG
560 570 580 590 600
VPVDELIEKA DGFAGVFPEH KYEIVRKLQE RKHIVGMTGD GVNDAPALKK
610 620 630 640 650
ADIGIAVDDA TDAARSASDI VLTEPGLSVI VSAVLTSRAI FQRMKNYTIY
660 670 680 690 700
AVSITIRIVL GFMLVALIWE FDFSPFMVLI IAILNDGTIM TISKDRVKPS
710 720 730 740 750
PIPDSWKLKE IFATGVVLGT YMALVTVVFF WLAHDTTFFS DKFGVRSLQG
760 770 780 790 800
KDEELIAVLY LQVSIISQAL IFVTRSRSWS FVERPGLLLL IAFFVAQLIA
810 820 830 840 850
TLIATYAHWE FARIKGCGWG WCGVIWIYSI VTYIPLDILK FITRYTLSGK
860 870 880 890 900
AWNNMIENRT AFTTKKDYGR GEREAQWALA QRTLHGLKPP ESMFEDTATY
910 920 930 940
TELSEIAEQA KKRAEVARLR EVHTLKGHVE SVVKLKGLDI DNLNQHYTV
Length:949
Mass (Da):105,012
Last modified:May 1, 2000 - v1
Checksum:i25C076607DB214EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007662 Genomic DNA. Translation: AAD32758.1.
CP002685 Genomic DNA. Translation: AEC06056.1.
BT002855 mRNA. Translation: AAO22672.1.
PIRiG84486.
RefSeqiNP_178762.1. NM_126721.2.
UniGeneiAt.40955.

Genome annotation databases

EnsemblPlantsiAT2G07560.1; AT2G07560.1; AT2G07560.
GeneIDi815329.
GrameneiAT2G07560.1; AT2G07560.1; AT2G07560.
KEGGiath:AT2G07560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007662 Genomic DNA. Translation: AAD32758.1.
CP002685 Genomic DNA. Translation: AEC06056.1.
BT002855 mRNA. Translation: AAO22672.1.
PIRiG84486.
RefSeqiNP_178762.1. NM_126721.2.
UniGeneiAt.40955.

3D structure databases

ProteinModelPortaliQ9SH76.
SMRiQ9SH76. Positions 15-845, 920-949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi719. 1 interaction.
IntActiQ9SH76. 1 interaction.
STRINGi3702.AT2G07560.1.

Protein family/group databases

TCDBi3.A.3.3.8. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiQ9SH76.

Proteomic databases

PaxDbiQ9SH76.
PRIDEiQ9SH76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G07560.1; AT2G07560.1; AT2G07560.
GeneIDi815329.
GrameneiAT2G07560.1; AT2G07560.1; AT2G07560.
KEGGiath:AT2G07560.

Organism-specific databases

TAIRiAT2G07560.

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.
InParanoidiQ9SH76.
KOiK01535.
OMAiNTITENR.
OrthoDBiEOG093602AD.
PhylomeDBiQ9SH76.

Enzyme and pathway databases

BioCyciARA:AT2G07560-MONOMER.

Miscellaneous databases

PROiQ9SH76.

Gene expression databases

GenevisibleiQ9SH76. AT.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMA6_ARATH
AccessioniPrimary (citable) accession number: Q9SH76
Secondary accession number(s): Q84WR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.