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Protein

ABC transporter B family member 10

Gene

ABCB10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi396 – 4038ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1017 – 10248ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G10680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 10
Short name:
ABC transporter ABCB.10
Short name:
AtABCB10
Alternative name(s):
Multidrug resistance protein 10
P-glycoprotein 10
Gene namesi
Name:ABCB10
Synonyms:MDR10, PGP10
Ordered Locus Names:At1g10680
ORF Names:F20B24.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G10680.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 6225HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei90 – 11021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei169 – 18820HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei297 – 31721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei663 – 68321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei704 – 72421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei784 – 80421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei806 – 82621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei889 – 90921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei927 – 94721HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12271227ABC transporter B family member 10PRO_0000227921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence analysis
Glycosylationi834 – 8341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SGY1.
PRIDEiQ9SGY1.

Expressioni

Tissue specificityi

Expressed in the sieve elements.1 Publication

Inductioni

Regulated by the transcription factors NAC045 and NAC086.1 Publication

Gene expression databases

GenevisibleiQ9SGY1. AT.

Interactioni

Subunit structurei

Interacts with 1-naphthylphthalamic acid (NPA).1 Publication

Protein-protein interaction databases

STRINGi3702.AT1G10680.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SGY1.
SMRiQ9SGY1. Positions 24-650, 658-1223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 330290ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 597237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini662 – 949288ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini982 – 1218237ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9SGY1.
KOiK05658.
OMAiHISEKIF.
PhylomeDBiQ9SGY1.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SGY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSNDPAIV DMAAAEKEKK RPSVSFLKLF SFADFYDCVL MALGSIGACI
60 70 80 90 100
HGASVPVFFI FFGKLINIIG LAYLFPQEAS HKVAKYSLDF VYLSVVILFS
110 120 130 140 150
SWLEVACWMH TGERQAAKIR KAYLRSMLSQ DISLFDTEIS TGEVISAITS
160 170 180 190 200
EILVVQDAIS EKVGNFMHFI SRFIAGFAIG FASVWQISLV TLSIVPFIAL
210 220 230 240 250
AGGIYAFVSS GLIVRVRKSY VKANEIAEEV IGNVRTVQAF TGEEKAVSSY
260 270 280 290 300
QGALRNTYNY GRKAGLAKGL GLGSLHFVLF LSWALLIWFT SIVVHKGIAN
310 320 330 340 350
GGESFTTMLN VVIAGLSLGQ AAPDISTFMR ASAAAYPIFQ MIERNTEDKT
360 370 380 390 400
GRKLGNVNGD ILFKDVTFTY PSRPDVVIFD KLNFVIPAGK VVALVGGSGS
410 420 430 440 450
GKSTMISLIE RFYEPTDGAV MLDGNDIRYL DLKWLRGHIG LVNQEPVLFA
460 470 480 490 500
TTIRENIMYG KDDATSEEIT NAAKLSEAIS FINNLPEGFE TQVGERGIQL
510 520 530 540 550
SGGQKQRISI SRAIVKNPSI LLLDEATSAL DAESEKIVQE ALDRVMVGRT
560 570 580 590 600
TVVVAHRLST VRNADIIAVV GGGKIIESGS HDELISNPDG AYSSLLRIQE
610 620 630 640 650
AASPNLNHTP SLPVSTKPLP ELPITETTSS IHQSVNQPDT TKQAKVTVGR
660 670 680 690 700
LYSMIRPDWK YGLCGTLGSF IAGSQMPLFA LGIAQALVSY YMDWETTQNE
710 720 730 740 750
VKRISILFCC GSVITVIVHT IEHTTFGIMG ERLTLRVRQK MFSAILRNEI
760 770 780 790 800
GWFDKVDNTS SMLASRLESD ATLLRTIVVD RSTILLENLG LVVTAFIISF
810 820 830 840 850
ILNWRLTLVV LATYPLIISG HISEKIFMQG YGGNLSKAYL KANMLAGESI
860 870 880 890 900
SNIRTVVAFC AEEKVLDLYS KELLEPSERS FRRGQMAGIL YGVSQFFIFS
910 920 930 940 950
SYGLALWYGS ILMEKGLSSF ESVMKTFMVL IVTALVMGEV LALAPDLLKG
960 970 980 990 1000
NQMVVSVFEL LDRRTQVVGD TGEELSNVEG TIELKGVHFS YPSRPDVTIF
1010 1020 1030 1040 1050
SDFNLLVPSG KSMALVGQSG SGKSSVLSLV LRFYDPTAGI IMIDGQDIKK
1060 1070 1080 1090 1100
LKLKSLRRHI GLVQQEPALF ATTIYENILY GKEGASESEV MEAAKLANAH
1110 1120 1130 1140 1150
SFISSLPEGY STKVGERGIQ MSGGQRQRIA IARAVLKNPE ILLLDEATSA
1160 1170 1180 1190 1200
LDVESERVVQ QALDRLMRDR TTVVVAHRLS TIKNSDMISV IQDGKIIEQG
1210 1220
SHNILVENKN GPYSKLISLQ QRQRHHP
Length:1,227
Mass (Da):134,475
Last modified:March 24, 2009 - v2
Checksum:i4B1AB2A1DF082348
GO

Sequence cautioni

The sequence AAF17668.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009398 Genomic DNA. Translation: AAF17668.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28628.1.
PIRiB86240.
RefSeqiNP_172538.1. NM_100944.1.
UniGeneiAt.51557.

Genome annotation databases

EnsemblPlantsiAT1G10680.1; AT1G10680.1; AT1G10680.
GeneIDi837611.
GrameneiAT1G10680.1; AT1G10680.1; AT1G10680.
KEGGiath:AT1G10680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009398 Genomic DNA. Translation: AAF17668.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28628.1.
PIRiB86240.
RefSeqiNP_172538.1. NM_100944.1.
UniGeneiAt.51557.

3D structure databases

ProteinModelPortaliQ9SGY1.
SMRiQ9SGY1. Positions 24-650, 658-1223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G10680.1.

Proteomic databases

PaxDbiQ9SGY1.
PRIDEiQ9SGY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G10680.1; AT1G10680.1; AT1G10680.
GeneIDi837611.
GrameneiAT1G10680.1; AT1G10680.1; AT1G10680.
KEGGiath:AT1G10680.

Organism-specific databases

TAIRiAT1G10680.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9SGY1.
KOiK05658.
OMAiHISEKIF.
PhylomeDBiQ9SGY1.

Enzyme and pathway databases

BioCyciARA:AT1G10680-MONOMER.

Miscellaneous databases

PROiQ9SGY1.

Gene expression databases

GenevisibleiQ9SGY1. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots."
    Terasaka K., Blakeslee J.J., Titapiwatanakun B., Peer W.A., Bandyopadhyay A., Makam S.N., Lee O.R., Richards E.L., Murphy A.S., Sato F., Yazaki K.
    Plant Cell 17:2922-2939(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-28; 29-40; 953-958 AND 1247-1254, INTERACTION WITH NPA.
  4. "The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
    Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
    J. Biol. Chem. 276:30231-30244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY, NOMENCLATURE.
  6. Cited for: INDUCTION BY NAC045 AND NAC086, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAB10B_ARATH
AccessioniPrimary (citable) accession number: Q9SGY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 24, 2009
Last modified: February 17, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.