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Protein

Probable phospholipid-transporting ATPase 5

Gene

ALA5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei425 – 42514-aspartylphosphate intermediateBy similarity
Metal bindingi879 – 8791MagnesiumBy similarity
Metal bindingi883 – 8831MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G72700-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 51 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA51 Publication
Alternative name(s):
Aminophospholipid flippase 51 Publication
Gene namesi
Name:ALA51 Publication
Ordered Locus Names:At1g72700Imported
ORF Names:F28P22.11Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G72700.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9622HelicalSequence analysisAdd
BLAST
Topological domaini97 – 1004ExtracellularSequence analysis
Transmembranei101 – 12323HelicalSequence analysisAdd
BLAST
Topological domaini124 – 305182CytoplasmicSequence analysisAdd
BLAST
Transmembranei306 – 32722HelicalSequence analysisAdd
BLAST
Topological domaini328 – 35932ExtracellularSequence analysisAdd
BLAST
Transmembranei360 – 37718HelicalSequence analysisAdd
BLAST
Topological domaini378 – 934557CytoplasmicSequence analysisAdd
BLAST
Transmembranei935 – 95420HelicalSequence analysisAdd
BLAST
Topological domaini955 – 96814ExtracellularSequence analysisAdd
BLAST
Transmembranei969 – 98820HelicalSequence analysisAdd
BLAST
Topological domaini989 – 101830CytoplasmicSequence analysisAdd
BLAST
Transmembranei1019 – 104123HelicalSequence analysisAdd
BLAST
Topological domaini1042 – 105413ExtracellularSequence analysisAdd
BLAST
Transmembranei1055 – 107723HelicalSequence analysisAdd
BLAST
Topological domaini1078 – 10836CytoplasmicSequence analysis
Transmembranei1084 – 110421HelicalSequence analysisAdd
BLAST
Topological domaini1105 – 111713ExtracellularSequence analysisAdd
BLAST
Transmembranei1118 – 114629HelicalSequence analysisAdd
BLAST
Topological domaini1147 – 122882CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12281228Probable phospholipid-transporting ATPase 5PRO_0000046389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki616 – 616Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9SGG3.
PRIDEiQ9SGG3.

PTM databases

iPTMnetiQ9SGG3.

Expressioni

Gene expression databases

GenevisibleiQ9SGG3. AT.

Interactioni

Protein-protein interaction databases

BioGridi28821. 1 interaction.
STRINGi3702.AT1G72700.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SGG3.
SMRiQ9SGG3. Positions 353-993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9SGG3.
KOiK01530.
OMAiNDILQFF.
PhylomeDBiQ9SGG3.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SGG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGRIRSKL RLSLLYTFGC LRPATLEGQD SQPIQGPGFS RTVFCNQPHM
60 70 80 90 100
HKKKPLRYRS NYVSTTRYNL ITFFPKSLYE QFHRAANLYF LVAAILSVFP
110 120 130 140 150
LSPFNKWSMI APLVFVVGLS MLKEALEDWR RFMQDVKINA RKTCVHKSDG
160 170 180 190 200
VFRQRKWKKV SVGDIVKVEK DEFFPADLLL LSSSYEDGIC YVETMNLDGE
210 220 230 240 250
TNLKVKRSLE VSLPLDDDES FKNFMATIRC EDPNPNLYTF VGNLEFERQT
260 270 280 290 300
FPLDPSQILL RDSKLRNTTY VYGVVVFTGF DTKVMQNSTK SPSKRSRIER
310 320 330 340 350
TMDYIIYTLL VLLILISCIS SSGFAWETEF HMPKMWYLRP GEPIDFTNPI
360 370 380 390 400
NPIYAGVVHL ITALLLYGYL IPISLYVSIE VVKVWQASFI NQDLHMYDDE
410 420 430 440 450
SGVPANARTS NLNEELGQVH TILSDKTGTL TCNQMDFLKC SIAGTSYGVR
460 470 480 490 500
SSEVEVAAAK QMAVDLEEHG EISSTPQSQT KVYGTWDSSR TQEIEVEGDN
510 520 530 540 550
NYNTPRAPIK GFGFEDNRLM NGNWLRESQP NDILQFFRIL AICHTAIPEL
560 570 580 590 600
NEETGKYTYE AESPDEASFL AAAREFGFEF FKRTQSSVFI RERFSGSGQI
610 620 630 640 650
IEREYKVLNL LEFTSKRKRM TVIVRDEEGQ ILLLCKGADS IIFERLAKNG
660 670 680 690 700
KTYLGPTTRH LTEYGEAGLR TLALAYRKLD EDEYAAWNSE FLKAKTSIGS
710 720 730 740 750
DRDELLETGA DMIEKELILI GATAVEDKLQ KGVPQCIDKL AQAGLKLWVL
760 770 780 790 800
TGDKMETAIN IGFACSLLRQ GMRQICITSM NSEGGSQDSK RVVKENILNQ
810 820 830 840 850
LTKAVQMVKL EKDPHAAFAL IIDGKTLTYA LEDDMKYQFL ALAVDCASVI
860 870 880 890 900
CCRVSPKQKA LVVRLVKEGT GKTTLAIGDG ANDVGMIQEA DIGVGISGVE
910 920 930 940 950
GMQAVMASDF SIAQFRFLER LLVVHGHWCY KRIAQMICYF FYKNIAFGLT
960 970 980 990 1000
LFYFEAFTGF SGQSVYNDYY LLLFNVVLTS LPVIALGVFE QDVSSEICLQ
1010 1020 1030 1040 1050
FPALYQQGTK NLFFDWSRIL GWMCNGVYAS LVIFFLNIGI IYSQAFRDNG
1060 1070 1080 1090 1100
QTADMDAVGT TMFTCIIWAA NVQIALTMSH FTWIQHVLIW GSIGMWYLFV
1110 1120 1130 1140 1150
AIYSMMPPSY SGNIYRILDE ILAPAPIYWM ATLLVTVAAV LPYVAHIAFQ
1160 1170 1180 1190 1200
RFLNPLDHHI IQEIKYYGRD IEDARLWTRE RTKAREKTKI GFTARVDAKI
1210 1220
RHLRSKLNKK QSNLSHFSAQ DAMSPRSL
Length:1,228
Mass (Da):139,342
Last modified:May 1, 2000 - v1
Checksum:i47E47A9297131CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA. Translation: AAG51844.1.
CP002684 Genomic DNA. Translation: AEE35362.1.
PIRiG96751.
RefSeqiNP_177414.1. NM_105929.4.
UniGeneiAt.35067.

Genome annotation databases

EnsemblPlantsiAT1G72700.1; AT1G72700.1; AT1G72700.
GeneIDi843602.
GrameneiAT1G72700.1; AT1G72700.1; AT1G72700.
KEGGiath:AT1G72700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA. Translation: AAG51844.1.
CP002684 Genomic DNA. Translation: AEE35362.1.
PIRiG96751.
RefSeqiNP_177414.1. NM_105929.4.
UniGeneiAt.35067.

3D structure databases

ProteinModelPortaliQ9SGG3.
SMRiQ9SGG3. Positions 353-993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28821. 1 interaction.
STRINGi3702.AT1G72700.1.

PTM databases

iPTMnetiQ9SGG3.

Proteomic databases

PaxDbiQ9SGG3.
PRIDEiQ9SGG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72700.1; AT1G72700.1; AT1G72700.
GeneIDi843602.
GrameneiAT1G72700.1; AT1G72700.1; AT1G72700.
KEGGiath:AT1G72700.

Organism-specific databases

TAIRiAT1G72700.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9SGG3.
KOiK01530.
OMAiNDILQFF.
PhylomeDBiQ9SGG3.

Enzyme and pathway databases

BioCyciARA:AT1G72700-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9SGG3.

Gene expression databases

GenevisibleiQ9SGG3. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Inventory of the superfamily of P-type ion pumps in Arabidopsis."
    Axelsen K.B., Palmgren M.G.
    Plant Physiol. 126:696-706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiALA5_ARATH
AccessioniPrimary (citable) accession number: Q9SGG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.