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Protein

Probable phosphoglucomutase, cytoplasmic 2

Gene

At1g70730

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme participates in both the breakdown and synthesis of glucose.By similarity

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Binding sitei25SubstrateBy similarity1
Active sitei124Phosphoserine intermediateBy similarity1
Metal bindingi124Magnesium; via phosphate groupBy similarity1
Binding sitei137SubstrateBy similarity1
Metal bindingi301MagnesiumBy similarity1
Metal bindingi303MagnesiumBy similarity1
Metal bindingi305MagnesiumBy similarity1
Binding sitei369SubstrateBy similarity1
Binding sitei401SubstrateBy similarity1
Binding sitei538SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi5.4.2.2 399
ReactomeiR-ATH-3322077 Glycogen synthesis
R-ATH-6798695 Neutrophil degranulation
R-ATH-70221 Glycogen breakdown (glycogenolysis)
R-ATH-70370 Galactose catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglucomutase, cytoplasmic 2 (EC:5.4.2.2)
Short name:
PGM 2
Alternative name(s):
Glucose phosphomutase 2
Gene namesi
Ordered Locus Names:At1g70730
ORF Names:F5A18.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G70730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477991 – 585Probable phosphoglucomutase, cytoplasmic 2Add BLAST585

Proteomic databases

PaxDbiQ9SGC1
PRIDEiQ9SGC1

PTM databases

iPTMnetiQ9SGC1

Expressioni

Gene expression databases

ExpressionAtlasiQ9SGC1 baseline and differential
GenevisibleiQ9SGC1 AT

Interactioni

Protein-protein interaction databases

BioGridi28630, 1 interactor
STRINGi3702.AT1G70730.3

Structurei

3D structure databases

ProteinModelPortaliQ9SGC1
SMRiQ9SGC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 125Substrate bindingBy similarity2
Regioni305 – 306Substrate bindingBy similarity2
Regioni388 – 390Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG0625 Eukaryota
COG0033 LUCA
HOGENOMiHOG000009550
InParanoidiQ9SGC1
KOiK01835
PhylomeDBiQ9SGC1

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR005841 Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PRINTSiPR00509 PGMPMM
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SGC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSFKVSLVS TSPIDGQKPG TSGLRKKVKV FKQPNYLENF VQATFNALTT
60 70 80 90 100
EKVKGATLVV SGDGRYYSEQ AIQIIVKMAA ANGVRRVWVG QNSLLSTPAV
110 120 130 140 150
SAIIRERVGA DGSKATGAFI LTASHNPGGP TEDFGIKYNM ENGGPAPESI
160 170 180 190 200
TDKIYENTKT IKEYPIAEDL PRVDISTIGI TSFEGPEGKF DVEVFDSADD
210 220 230 240 250
YVKLMKSIFD FESIKKLLSY PKFTFCYDAL HGVAGAYAHR IFVEELGAPE
260 270 280 290 300
SSLLNCVPKE DFGGGHPDPN LTYAKELVAR MGLSKTDDAG GEPPEFGAAA
310 320 330 340 350
DGDADRNMIL GKRFFVTPSD SVAIIAANAV GAIPYFSSGL KGVARSMPTS
360 370 380 390 400
AALDVVAKNL GLKFFEVPTG WKFFGNLMDA GMCSVCGEES FGTGSDHIRE
410 420 430 440 450
KDGIWAVLAW LSILAHKNKE TLDGNAKLVT VEDIVRQHWA TYGRHYYTRY
460 470 480 490 500
DYENVDATAA KELMGLLVKL QSSLPEVNKI IKGIHPEVAN VASADEFEYK
510 520 530 540 550
DPVDGSVSKH QGIRYLFEDG SRLVFRLSGT GSEGATIRLY IEQYEKDASK
560 570 580
IGRDSQDALG PLVDVALKLS KMQEFTGRSS PTVIT
Length:585
Mass (Da):63,482
Last modified:May 1, 2000 - v1
Checksum:i9384EA96CEEED84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011663 Genomic DNA Translation: AAG52345.1
CP002684 Genomic DNA Translation: AEE35105.1
AY090231 mRNA Translation: AAL90895.1
BT002627 mRNA Translation: AAO11543.1
PIRiG96731
RefSeqiNP_177230.1, NM_105741.4 [Q9SGC1-1]
UniGeneiAt.35274

Genome annotation databases

EnsemblPlantsiAT1G70730.1; AT1G70730.1; AT1G70730 [Q9SGC1-1]
AT1G70730.3; AT1G70730.3; AT1G70730
GeneIDi843410
GrameneiAT1G70730.1; AT1G70730.1; AT1G70730 [Q9SGC1-1]
AT1G70730.3; AT1G70730.3; AT1G70730
KEGGiath:AT1G70730

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPGMC2_ARATH
AccessioniPrimary (citable) accession number: Q9SGC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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