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Protein

Probable phosphoglucomutase, cytoplasmic 2

Gene

At1g70730

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This enzyme participates in both the breakdown and synthesis of glucose.By similarity

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211SubstrateBy similarity
Binding sitei25 – 251SubstrateBy similarity
Active sitei124 – 1241Phosphoserine intermediateBy similarity
Metal bindingi124 – 1241Magnesium; via phosphate groupBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Metal bindingi301 – 3011MagnesiumBy similarity
Metal bindingi303 – 3031MagnesiumBy similarity
Metal bindingi305 – 3051MagnesiumBy similarity
Binding sitei369 – 3691SubstrateBy similarity
Binding sitei401 – 4011SubstrateBy similarity
Binding sitei538 – 5381SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G70730-MONOMER.
ARA:GQT-1374-MONOMER.
ARA:GQT-1375-MONOMER.
BRENDAi5.4.2.2. 399.
ReactomeiR-ATH-3322077. Glycogen synthesis.
R-ATH-70221. Glycogen breakdown (glycogenolysis).
R-ATH-70370. Galactose catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglucomutase, cytoplasmic 2 (EC:5.4.2.2)
Short name:
PGM 2
Alternative name(s):
Glucose phosphomutase 2
Gene namesi
Ordered Locus Names:At1g70730
ORF Names:F5A18.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G70730.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Probable phosphoglucomutase, cytoplasmic 2PRO_0000147799Add
BLAST

Proteomic databases

PaxDbiQ9SGC1.
PRIDEiQ9SGC1.

PTM databases

iPTMnetiQ9SGC1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SGC1. baseline and differential.
GenevisibleiQ9SGC1. AT.

Interactioni

Protein-protein interaction databases

BioGridi28630. 1 interaction.
STRINGi3702.AT1G70730.3.

Structurei

3D structure databases

ProteinModelPortaliQ9SGC1.
SMRiQ9SGC1. Positions 5-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Substrate bindingBy similarity
Regioni305 – 3062Substrate bindingBy similarity
Regioni388 – 3903Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
HOGENOMiHOG000009550.
InParanoidiQ9SGC1.
KOiK01835.
PhylomeDBiQ9SGC1.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SGC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSFKVSLVS TSPIDGQKPG TSGLRKKVKV FKQPNYLENF VQATFNALTT
60 70 80 90 100
EKVKGATLVV SGDGRYYSEQ AIQIIVKMAA ANGVRRVWVG QNSLLSTPAV
110 120 130 140 150
SAIIRERVGA DGSKATGAFI LTASHNPGGP TEDFGIKYNM ENGGPAPESI
160 170 180 190 200
TDKIYENTKT IKEYPIAEDL PRVDISTIGI TSFEGPEGKF DVEVFDSADD
210 220 230 240 250
YVKLMKSIFD FESIKKLLSY PKFTFCYDAL HGVAGAYAHR IFVEELGAPE
260 270 280 290 300
SSLLNCVPKE DFGGGHPDPN LTYAKELVAR MGLSKTDDAG GEPPEFGAAA
310 320 330 340 350
DGDADRNMIL GKRFFVTPSD SVAIIAANAV GAIPYFSSGL KGVARSMPTS
360 370 380 390 400
AALDVVAKNL GLKFFEVPTG WKFFGNLMDA GMCSVCGEES FGTGSDHIRE
410 420 430 440 450
KDGIWAVLAW LSILAHKNKE TLDGNAKLVT VEDIVRQHWA TYGRHYYTRY
460 470 480 490 500
DYENVDATAA KELMGLLVKL QSSLPEVNKI IKGIHPEVAN VASADEFEYK
510 520 530 540 550
DPVDGSVSKH QGIRYLFEDG SRLVFRLSGT GSEGATIRLY IEQYEKDASK
560 570 580
IGRDSQDALG PLVDVALKLS KMQEFTGRSS PTVIT
Length:585
Mass (Da):63,482
Last modified:May 1, 2000 - v1
Checksum:i9384EA96CEEED84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011663 Genomic DNA. Translation: AAG52345.1.
CP002684 Genomic DNA. Translation: AEE35105.1.
AY090231 mRNA. Translation: AAL90895.1.
BT002627 mRNA. Translation: AAO11543.1.
PIRiG96731.
RefSeqiNP_177230.1. NM_105741.4. [Q9SGC1-1]
UniGeneiAt.35274.

Genome annotation databases

EnsemblPlantsiAT1G70730.1; AT1G70730.1; AT1G70730. [Q9SGC1-1]
GeneIDi843410.
KEGGiath:AT1G70730.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011663 Genomic DNA. Translation: AAG52345.1.
CP002684 Genomic DNA. Translation: AEE35105.1.
AY090231 mRNA. Translation: AAL90895.1.
BT002627 mRNA. Translation: AAO11543.1.
PIRiG96731.
RefSeqiNP_177230.1. NM_105741.4. [Q9SGC1-1]
UniGeneiAt.35274.

3D structure databases

ProteinModelPortaliQ9SGC1.
SMRiQ9SGC1. Positions 5-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28630. 1 interaction.
STRINGi3702.AT1G70730.3.

PTM databases

iPTMnetiQ9SGC1.

Proteomic databases

PaxDbiQ9SGC1.
PRIDEiQ9SGC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G70730.1; AT1G70730.1; AT1G70730. [Q9SGC1-1]
GeneIDi843410.
KEGGiath:AT1G70730.

Organism-specific databases

TAIRiAT1G70730.

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
HOGENOMiHOG000009550.
InParanoidiQ9SGC1.
KOiK01835.
PhylomeDBiQ9SGC1.

Enzyme and pathway databases

BioCyciARA:AT1G70730-MONOMER.
ARA:GQT-1374-MONOMER.
ARA:GQT-1375-MONOMER.
BRENDAi5.4.2.2. 399.
ReactomeiR-ATH-3322077. Glycogen synthesis.
R-ATH-70221. Glycogen breakdown (glycogenolysis).
R-ATH-70370. Galactose catabolism.

Miscellaneous databases

PROiQ9SGC1.

Gene expression databases

ExpressionAtlasiQ9SGC1. baseline and differential.
GenevisibleiQ9SGC1. AT.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGMC2_ARATH
AccessioniPrimary (citable) accession number: Q9SGC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.