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Protein

SUN domain-containing protein 2

Gene

SUN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (PubMed:24667841). Required for the maintenance and/or formation of polarized nuclear shape in root hairs (PubMed:21294795). Modulates the anchoring and mobility of WIP proteins in the nuclear envelope (NE) (PubMed:22270916). In association with SUN1, may be involved in telomere attachment to nuclear envelope in the prophase of meiosis (PubMed:25412930). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).5 Publications

GO - Molecular functioni

  • protein membrane anchor Source: UniProtKB
  • protein self-association Source: UniProtKB

GO - Biological processi

  • meiotic attachment of telomere to nuclear envelope Source: UniProtKB
  • nucleus organization Source: UniProtKB
  • protein heterooligomerization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • protein localization to nuclear envelope Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 21 Publication
Short name:
AtSUN21 Publication
Gene namesi
Name:SUN21 Publication
Ordered Locus Names:At3g10730Imported
ORF Names:T7M13.19Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G10730
TAIRilocus:2103182 AT3G10730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 105NuclearCuratedAdd BLAST104
Transmembranei106 – 128HelicalSequence analysisAdd BLAST23
Topological domaini129 – 455Perinuclear spaceCuratedAdd BLAST327

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. When associated with SUN1 disruption, abnormal nuclear shape in some cells such as mature root hairs but also numerous meiotic defects namely a delay in the progression of meiosis, absence of full synapsis and a reduction in the mean cell chiasma frequency.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi434H → A: Strongly affects binding to SINE1, SINE2, SINE3 and SINE4; when associated with F-438. 1 Publication1
Mutagenesisi438Y → F: Strongly affects binding to SINE1, SINE2, SINE3 and SINE4; when associated with A-434. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004328172 – 455SUN domain-containing protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei63PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9SG79

PTM databases

iPTMnetiQ9SG79

Expressioni

Tissue specificityi

Expressed in roots, hypocotyls, cotyledons and leaves and inflorescences.2 Publications

Inductioni

Up-regulated in proliferating tissues.1 Publication

Gene expression databases

ExpressionAtlasiQ9SG79 baseline and differential
GenevisibleiQ9SG79 AT

Interactioni

Subunit structurei

Forms homomers (e.g. dimers, trimers and tetramers) and heteromers with SUN1 (PubMed:19807882, PubMed:25217773). Interacts with SUN3, SUN4 and TIK (PubMed:25217773). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane WIP and WIT proteins. The LINC complex also involves nucleoskeletal proteins CRWN/LINC and possibly KAKU4 and the cytoskeletal myosin KAKU1 (PubMed:25759303). Interacts with LINC1, WIP1, WIP2 and WIP3 at the nuclear envelope (NE) (PubMed:22270916, PubMed:23973298, PubMed:24667841). Interacts with SINE1, SINE2, SINE3 AND SINE4 (PubMed:24891605). Interacts with NEAP1, NEA2 and NEAP3 (PubMed:27630107).8 Publications

GO - Molecular functioni

  • protein membrane anchor Source: UniProtKB
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

IntActiQ9SG79, 1 interactor
STRINGi3702.AT3G10730.1

Structurei

3D structure databases

ProteinModelPortaliQ9SG79
SMRiQ9SG79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 447SUNPROSITE-ProRule annotationAdd BLAST163

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 225Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi88 – 95Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 87Poly-ThrSequence analysis10

Domaini

The SUN domain may play a role in the nuclear anchoring and/or migration (By similarity). The SUN domain is required for interactions with WIP proteins (PubMed:22270916).By similarity1 Publication

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687 Eukaryota
ENOG410YM6S LUCA
HOGENOMiHOG000237750
KOiK19347
OMAiVKHSEPF
OrthoDBiEOG093609UX
PhylomeDBiQ9SG79

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR012919 SUN_dom
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SG79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASTVSITA SPRTIRRTPV LSGEKKSNFD FPPSESHANA AIGESSAGTN
60 70 80 90 100
KDLIRAEAAG ERSNTYDVGP VTRKSGSTAT GTNTTTTQRR TRKSQGNKID
110 120 130 140 150
RGKWKTVVRV FAKQFGALLL LVGLIQLIRK LTLKDSSLSS SNFPIETEMV
160 170 180 190 200
LSELESRISA VDGLVKTTTK MMQVQVEFLD KKMDSESRAL RQTIDSTSSV
210 220 230 240 250
LHSELKKVES KTERLQVSVD ELNAKPLVSR EELERVYEEL KKGKVGDSDV
260 270 280 290 300
NIDKLRAYAR DIVEKEIGKH VADGLGRVDY ALASGGAFVM GHSDPFLVGN
310 320 330 340 350
GRNWFGTSRR RVHSKAVKML TPSFGEPGQC FPLKGSNGYV LVRLRAPIIP
360 370 380 390 400
EAVTLEHVSK AVAYDRSSAP KDCRVSGWLG DIDMETETMP LLTEFSYDLD
410 420 430 440 450
RSNAQTFDIA DSAHSGLVNT VRLDFNSNHG SSSHTCIYRF RVHGRELDSV

SVAHA
Length:455
Mass (Da):49,940
Last modified:May 1, 2000 - v1
Checksum:iBB99EFF2B3EBF917
GO

Sequence cautioni

The sequence AAM65947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302R → G in AAM65947 (Ref. 5) Curated1
Sequence conflicti398D → N in AAM65947 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011708 Genomic DNA Translation: AAF19576.1
CP002686 Genomic DNA Translation: AEE74948.1
AK118080 mRNA Translation: BAC42710.1
BT006045 mRNA Translation: AAP04030.1
AY088410 mRNA Translation: AAM65947.1 Different initiation.
RefSeqiNP_566380.2, NM_111910.4
UniGeneiAt.43435

Genome annotation databases

EnsemblPlantsiAT3G10730.1; AT3G10730.1; AT3G10730
GeneIDi820242
GrameneiAT3G10730.1; AT3G10730.1; AT3G10730
KEGGiath:AT3G10730

Similar proteinsi

Entry informationi

Entry nameiSUN2_ARATH
AccessioniPrimary (citable) accession number: Q9SG79
Secondary accession number(s): Q8L9I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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