Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9SFH9 (HEM2_ARATH)

Last modified February 9, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Delta-aminolevulinic acid dehydratase, chloroplastic
      Short name=ALADH
    EC=4.2.1.24
Alternative name(s):
    Porphobilinogen synthase
Gene names
Name: HEMB
Ordered Locus Names: At1g69740
ORF Names: T6C23.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeArabidopsis

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactor

Magnesium By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Subunit structure

Homooctamer By similarity.

Subcellular location

Plastidchloroplast By similarity.

Sequence similarities

Belongs to the ALADH family.

Ontologies

Keywords
   Biological processChlorophyll biosynthesis
Porphyrin biosynthesis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processchlorophyll biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloroplast stroma

Inferred from direct assay. Source: TAIR

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

porphobilinogen synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast By similarity
Chain? – 430Delta-aminolevulinic acid dehydratase, chloroplasticPRO_0000013314

Regions

Region219 – 23719Magnesium-binding By similarity

Sites

Active site3511 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9SFH9-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 44B0984247FC6147

FASTA43046,690
        10         20         30         40         50         60 
MATTPIFNAS CSFPSTRGID CKSYIGLRSN VSKVSVASSR IATSQRRNLV VRASESGNGH 

        70         80         90        100        110        120 
AKKLGMSDAE CEAAVAAGNV PEAPPVPPKP AAPVGTPIIK PLNLSRRPRR NRASPVTRAA 

       130        140        150        160        170        180 
FQETDISPAN FVYPLFIHEG EEDTPIGAMP GCYRLGWRHG LVQEVAKARA VGVNSIVLFP 

       190        200        210        220        230        240 
KVPEALKNST GDEAYNDNGL VPRTIRLLKD KYPDLIIYTD VALDPYSSDG HDGIVREDGV 

       250        260        270        280        290        300 
IMNDETVHQL CKQAVSQARA GADVVSPSDM MDGRVGAIRS ALDAEGFQNV SIMSYTAKYA 

       310        320        330        340        350        360 
SSFYGPFREA LDSNPRFGDK KTYQMNPANY REALIEARED EAEGADILLV KPGLPYLDII 

       370        380        390        400        410        420 
RLLRDKSPLP IAAYQVSGEY SMIKAGGVLK MIDEEKVMME SLMCLRRAGA DIILTYFALQ 

       430 
AATCLCGEKR 

« Hide

References

[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC013289 Genomic DNA. Translation: AAG52549.1.
AF327428 mRNA. Translation: AAG42018.1.
AF361803 mRNA. Translation: AAK32816.1.
AY059154 mRNA. Translation: AAL15379.1.
AY081254 mRNA. Translation: AAL91143.1.
AY113941 mRNA. Translation: AAM44989.1.
AY120705 mRNA. Translation: AAM53263.1.
AY128711 mRNA. Translation: AAM91111.1.
IPIIPI00537155.
PIRD96719.
RefSeqNP_001077800.1.
NP_177132.1.
UniGeneAt.10020
At.21048

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9SFH9.

Proteomic databases

PRIDEQ9SFH9.
ProMEXQ9SFH9.

Genome annotation databases

GeneID843310.
GenomeReviewsGene locus AT1G69740 in contig CT485782_GR.
KEGGath:AT1G69740.
NMPDRfig|3702.1.peg.6446.

Organism-specific databases

TAIRAt1g69740.

Phylogenomic databases

eggNOGKOG2794.
HOGENOMHBG285270.
InParanoidQ9SFH9.
OMADPFTSHG.
PhylomeDBQ9SFH9.

Enzyme and pathway databases

BRENDA4.2.1.24. 302.

Gene expression databases

ArrayExpressQ9SFH9.
GenevestigatorQ9SFH9.
GermOnlineAT1G69740. Arabidopsis thaliana.

Family and domain databases

InterProIPR001731. 4pyrrol_synth_porphobiln_synth.
IPR013785. Aldolase_TIM.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PRINTSPR00144. DALDHYDRTASE.
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM2_ARATH
AccessionPrimary (citable) accession number: Q9SFH9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents