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Protein

Sugar transport protein 6

Gene

STP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, mannose, fructose and galactose, and, to a lower extent, xylose and ribulose.1 Publication

Enzyme regulationi

Inhibited by uncouplers such as 2,4-dinitrophenol and carbonyl cyanide-m-chlorophenyl-hydrazone.1 Publication

Kineticsi

  1. KM=20.5 µM for glucose (at pH 5.5)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • carbohydrate transmembrane transport Source: TAIR
    • glucose import Source: GO_Central

    Keywordsi

    Biological processSugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.56 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 6
    Alternative name(s):
    Hexose transporter 6
    Gene namesi
    Name:STP6
    Ordered Locus Names:At3g05960
    ORF Names:F2O10.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    AraportiAT3G05960
    TAIRilocus:2083003 AT3G05960

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
    Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei199 – 219Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei318 – 338Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei345 – 365Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei381 – 401Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei418 – 438Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei447 – 467Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini468 – 507CytoplasmicSequence analysisAdd BLAST40

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504361 – 507Sugar transport protein 6Add BLAST507

    Proteomic databases

    PaxDbiQ9SFG0

    Expressioni

    Tissue specificityi

    Pollen specific.1 Publication

    Developmental stagei

    First observed in pollen right before the opening of floral buds. Levels increase during pollen maturation.1 Publication

    Gene expression databases

    ExpressionAtlasiQ9SFG0 baseline and differential
    GenevisibleiQ9SFG0 AT

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G05960.1

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SFG0
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi428 – 466Phe-richAdd BLAST39

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    HOGENOMiHOG000202867
    InParanoidiQ9SFG0
    OMAiKMVVIFQ
    OrthoDBiEOG093608YP
    PhylomeDBiQ9SFG0

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9SFG0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAVVVSNANA PAFEAKMTVY VFICVMIAAV GGLIFGYDIG ISGGVSAMDD
    60 70 80 90 100
    FLKEFFPAVW ERKKHVHENN YCKYDNQFLQ LFTSSLYLAA LVASFVASAT
    110 120 130 140 150
    CSKLGRRPTM QFASIFFLIG VGLTAGAVNL VMLIIGRLFL GFGVGFGNQA
    160 170 180 190 200
    VPLFLSEIAP AQLRGGLNIV FQLMVTIGIL IANIVNYFTA TVHPYGWRIA
    210 220 230 240 250
    LGGAGIPAVI LLFGSLLIIE TPTSLIERNK NEEGKEALRK IRGVDDINDE
    260 270 280 290 300
    YESIVHACDI ASQVKDPYRK LLKPASRPPF IIGMLLQLFQ QFTGINAIMF
    310 320 330 340 350
    YAPVLFQTVG FGSDAALLSA VITGSINVLA TFVGIYLVDR TGRRFLLLQS
    360 370 380 390 400
    SVHMLICQLI IGIILAKDLG VTGTLGRPQA LVVVIFVCVY VMGFAWSWGP
    410 420 430 440 450
    LGWLIPSETF PLETRSAGFA VAVSCNMFFT FVIAQAFLSM LCGMRSGIFF
    460 470 480 490 500
    FFSGWIIVMG LFAFFFIPET KGIAIDDMRE SVWKPHWFWK RYMLPEDDHH

    DIEKRNA
    Length:507
    Mass (Da):55,907
    Last modified:May 1, 2000 - v1
    Checksum:iFC8060B57C4DA810
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ344337 mRNA Translation: CAC69073.1
    AC013454 Genomic DNA Translation: AAF23220.1
    CP002686 Genomic DNA Translation: AEE74323.1
    AJ001659 Genomic DNA Translation: CAA04904.1
    RefSeqiNP_187247.1, NM_111470.2
    UniGeneiAt.26445

    Genome annotation databases

    EnsemblPlantsiAT3G05960.1; AT3G05960.1; AT3G05960
    GeneIDi819766
    GrameneiAT3G05960.1; AT3G05960.1; AT3G05960
    KEGGiath:AT3G05960

    Similar proteinsi

    Entry informationi

    Entry nameiSTP6_ARATH
    AccessioniPrimary (citable) accession number: Q9SFG0
    Secondary accession number(s): O81704
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: May 1, 2000
    Last modified: April 25, 2018
    This is version 112 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health