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Protein

Sugar transport protein 6

Gene

STP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, mannose, fructose and galactose, and, to a lower extent, xylose and ribulose.1 Publication

Enzyme regulationi

Inhibited by uncouplers such as 2,4-dinitrophenol and carbonyl cyanide-m-chlorophenyl-hydrazone.1 Publication

Kineticsi

  1. KM=20.5 µM for glucose (at pH 5.5)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • carbohydrate transmembrane transport Source: TAIR
    • glucose import Source: GO_Central
    • hexose transmembrane transport Source: GO_Central
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.56. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 6
    Alternative name(s):
    Hexose transporter 6
    Gene namesi
    Name:STP6
    Ordered Locus Names:At3g05960
    ORF Names:F2O10.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    TAIRiAT3G05960.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
    Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei199 – 219Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei318 – 338Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei345 – 365Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei381 – 401Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei418 – 438Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei447 – 467Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini468 – 507CytoplasmicSequence analysisAdd BLAST40

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504361 – 507Sugar transport protein 6Add BLAST507

    Proteomic databases

    PaxDbiQ9SFG0.

    Expressioni

    Tissue specificityi

    Pollen specific.1 Publication

    Developmental stagei

    First observed in pollen right before the opening of floral buds. Levels increase during pollen maturation.1 Publication

    Gene expression databases

    GenevisibleiQ9SFG0. AT.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G05960.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SFG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi428 – 466Phe-richAdd BLAST39

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9SFG0.
    OMAiHACDIAS.
    OrthoDBiEOG093608YP.
    PhylomeDBiQ9SFG0.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9SFG0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAVVVSNANA PAFEAKMTVY VFICVMIAAV GGLIFGYDIG ISGGVSAMDD
    60 70 80 90 100
    FLKEFFPAVW ERKKHVHENN YCKYDNQFLQ LFTSSLYLAA LVASFVASAT
    110 120 130 140 150
    CSKLGRRPTM QFASIFFLIG VGLTAGAVNL VMLIIGRLFL GFGVGFGNQA
    160 170 180 190 200
    VPLFLSEIAP AQLRGGLNIV FQLMVTIGIL IANIVNYFTA TVHPYGWRIA
    210 220 230 240 250
    LGGAGIPAVI LLFGSLLIIE TPTSLIERNK NEEGKEALRK IRGVDDINDE
    260 270 280 290 300
    YESIVHACDI ASQVKDPYRK LLKPASRPPF IIGMLLQLFQ QFTGINAIMF
    310 320 330 340 350
    YAPVLFQTVG FGSDAALLSA VITGSINVLA TFVGIYLVDR TGRRFLLLQS
    360 370 380 390 400
    SVHMLICQLI IGIILAKDLG VTGTLGRPQA LVVVIFVCVY VMGFAWSWGP
    410 420 430 440 450
    LGWLIPSETF PLETRSAGFA VAVSCNMFFT FVIAQAFLSM LCGMRSGIFF
    460 470 480 490 500
    FFSGWIIVMG LFAFFFIPET KGIAIDDMRE SVWKPHWFWK RYMLPEDDHH

    DIEKRNA
    Length:507
    Mass (Da):55,907
    Last modified:May 1, 2000 - v1
    Checksum:iFC8060B57C4DA810
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ344337 mRNA. Translation: CAC69073.1.
    AC013454 Genomic DNA. Translation: AAF23220.1.
    CP002686 Genomic DNA. Translation: AEE74323.1.
    AJ001659 Genomic DNA. Translation: CAA04904.1.
    RefSeqiNP_187247.1. NM_111470.2.
    UniGeneiAt.26445.

    Genome annotation databases

    EnsemblPlantsiAT3G05960.1; AT3G05960.1; AT3G05960.
    GeneIDi819766.
    GrameneiAT3G05960.1; AT3G05960.1; AT3G05960.
    KEGGiath:AT3G05960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ344337 mRNA. Translation: CAC69073.1.
    AC013454 Genomic DNA. Translation: AAF23220.1.
    CP002686 Genomic DNA. Translation: AEE74323.1.
    AJ001659 Genomic DNA. Translation: CAA04904.1.
    RefSeqiNP_187247.1. NM_111470.2.
    UniGeneiAt.26445.

    3D structure databases

    ProteinModelPortaliQ9SFG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT3G05960.1.

    Protein family/group databases

    TCDBi2.A.1.1.56. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbiQ9SFG0.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT3G05960.1; AT3G05960.1; AT3G05960.
    GeneIDi819766.
    GrameneiAT3G05960.1; AT3G05960.1; AT3G05960.
    KEGGiath:AT3G05960.

    Organism-specific databases

    TAIRiAT3G05960.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9SFG0.
    OMAiHACDIAS.
    OrthoDBiEOG093608YP.
    PhylomeDBiQ9SFG0.

    Miscellaneous databases

    PROiQ9SFG0.

    Gene expression databases

    GenevisibleiQ9SFG0. AT.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSTP6_ARATH
    AccessioniPrimary (citable) accession number: Q9SFG0
    Secondary accession number(s): O81704
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: May 1, 2000
    Last modified: November 30, 2016
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.