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Protein

Phosphatidylinositol 4-phosphate 5-kinase 6

Gene

PIP5K6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • clathrin-dependent endocytosis Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G07960-MONOMER
ReactomeiR-ATH-1660499 Synthesis of PIPs at the plasma membrane
R-ATH-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-ATH-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 6 (EC:2.7.1.68)
Short name:
AtPIP5K6
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 6
Diphosphoinositide kinase 6
PtdIns(4)P-5-kinase 6
Gene namesi
Name:PIP5K6
Ordered Locus Names:At3g07960
ORF Names:F17A17.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G07960
TAIRilocus:2077397 AT3G07960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854781 – 715Phosphatidylinositol 4-phosphate 5-kinase 6Add BLAST715

Proteomic databases

PaxDbiQ9SFB8

PTM databases

iPTMnetiQ9SFB8

Expressioni

Gene expression databases

ExpressionAtlasiQ9SFB8 baseline and differential
GenevisibleiQ9SFB8 AT

Interactioni

Protein-protein interaction databases

BioGridi53221 interactor.
STRINGi3702.AT3G07960.1

Structurei

3D structure databases

ProteinModelPortaliQ9SFB8
SMRiQ9SFB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 54MORN 1Add BLAST23
Repeati55 – 77MORN 2Add BLAST23
Repeati78 – 100MORN 3Add BLAST23
Repeati101 – 123MORN 4Add BLAST23
Repeati124 – 146MORN 5Add BLAST23
Repeati147 – 169MORN 6Add BLAST23
Repeati170 – 192MORN 7Add BLAST23
Repeati193 – 214MORN 8Add BLAST22
Domaini321 – 711PIPKPROSITE-ProRule annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni671 – 692Activation loopBy similarityAdd BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG4642 LUCA
COG5253 LUCA
HOGENOMiHOG000193875
InParanoidiQ9SFB8
KOiK00889
OMAiFRESSCN
OrthoDBiEOG093602F1
PhylomeDBiQ9SFB8

Family and domain databases

Gene3Di3.30.800.101 hit
3.30.810.102 hits
InterProiView protein in InterPro
IPR003409 MORN
IPR017163 PIno-4-P-5_kinase_pln
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF01504 PIP5K, 1 hit
PIRSFiPIRSF037274 PIP5K_plant_prd, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 7 hits
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SFB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAHADDAD DYSRPTGESY HAEKALPSGD FYTGQWRDNL PHGHGKYLWT
60 70 80 90 100
DGCMYVGDWH RGKTMGKGRF SWPSGATYEG DFKNGYMDGK GTYIDSSGDL
110 120 130 140 150
YRGSWVMNLR HGQGTKSYVN GDCYDGEWRR GLQDGHGRYQ WKNENHYIGQ
160 170 180 190 200
WKNGLMNGNG TMIWSNGNRY DGSWEDGAPK GNGTFRWSDG SFYVGVWSKD
210 220 230 240 250
PKEQNGTYYP STSSGNFDWQ PQQVFYVDLS ECVVCTCQRI PVLPSQKMPV
260 270 280 290 300
WYGASEQSSS GNRTKNSERP RRRSVDGRVS NGEMELRSNG SGYLQVDDNA
310 320 330 340 350
ESTRSSLGPL RIQPAKKQGQ TISKGHKNYE LMLNLQLGIR HSVGRPAPAT
360 370 380 390 400
SLDLKASAFD PKEKLWTKFP SEGSKYTPPH QSCEFKWKDY CPVVFRTLRK
410 420 430 440 450
LFSVDAADYM LSICGNDALR ELSSPGKSGS FFYLTNDDRY MIKTMKKAET
460 470 480 490 500
KVLIRMLPAY YNHVRACENT LVTKFFGLHC VKLTGTAQKK VRFVIMGNLF
510 520 530 540 550
CTGHSIHRRF DLKGSSHGRL TTKPESEIDP NTTLKDLDLN FAFRLQKNWF
560 570 580 590 600
QEFCRQVDRD CEFLEQERIM DYSLLVGLHF REAAIKDSAT PTSGARTPTG
610 620 630 640 650
NSETRLSRAE MDRFLLDASK LASIKLGINM PARVERTARR SDCENQLVGD
660 670 680 690 700
PTGEFYDVIV YFGIIDILQD YDISKKLEHA YKSMQYDPTS ISAVDPKQYS
710
RRFRDFIFRV FVEDA
Length:715
Mass (Da):81,422
Last modified:May 1, 2000 - v1
Checksum:i795D86CEB1FB52E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013483 Genomic DNA Translation: AAF21206.1
CP002686 Genomic DNA Translation: AEE74625.1
BT008595 mRNA Translation: AAP40421.1
RefSeqiNP_187453.1, NM_111675.6
UniGeneiAt.40277

Genome annotation databases

EnsemblPlantsiAT3G07960.1; AT3G07960.1; AT3G07960
GeneIDi819987
GrameneiAT3G07960.1; AT3G07960.1; AT3G07960
KEGGiath:AT3G07960

Similar proteinsi

Entry informationi

Entry nameiPI5K6_ARATH
AccessioniPrimary (citable) accession number: Q9SFB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome