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Q9SFB8

- PI5K6_ARATH

UniProt

Q9SFB8 - PI5K6_ARATH

Protein

Phosphatidylinositol 4-phosphate 5-kinase 6

Gene

PIP5K6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. clathrin-mediated endocytosis Source: TAIR
    2. phosphatidylinositol phosphorylation Source: GOC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G07960-MONOMER.
    ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase 6 (EC:2.7.1.68)
    Short name:
    AtPIP5K6
    Alternative name(s):
    1-phosphatidylinositol 4-phosphate kinase 6
    Diphosphoinositide kinase 6
    PtdIns(4)P-5-kinase 6
    Gene namesi
    Name:PIP5K6
    Ordered Locus Names:At3g07960
    ORF Names:F17A17.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G07960.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: TAIR
    2. pollen tube Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Phosphatidylinositol 4-phosphate 5-kinase 6PRO_0000185478Add
    BLAST

    Proteomic databases

    PaxDbiQ9SFB8.
    PRIDEiQ9SFB8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9SFB8.

    Interactioni

    Protein-protein interaction databases

    BioGridi5322. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SFB8.
    SMRiQ9SFB8. Positions 331-707.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati32 – 5423MORN 1Add
    BLAST
    Repeati55 – 7723MORN 2Add
    BLAST
    Repeati78 – 10023MORN 3Add
    BLAST
    Repeati101 – 12323MORN 4Add
    BLAST
    Repeati124 – 14623MORN 5Add
    BLAST
    Repeati147 – 16923MORN 6Add
    BLAST
    Repeati170 – 19223MORN 7Add
    BLAST
    Repeati193 – 21422MORN 8Add
    BLAST
    Domaini321 – 711391PIPKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni671 – 69222Activation loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 8 MORN repeats.Curated
    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000193875.
    InParanoidiQ9SFB8.
    KOiK00889.
    OMAiQYAIHRR.
    PhylomeDBiQ9SFB8.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF02493. MORN. 7 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTiSM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9SFB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVAHADDAD DYSRPTGESY HAEKALPSGD FYTGQWRDNL PHGHGKYLWT    50
    DGCMYVGDWH RGKTMGKGRF SWPSGATYEG DFKNGYMDGK GTYIDSSGDL 100
    YRGSWVMNLR HGQGTKSYVN GDCYDGEWRR GLQDGHGRYQ WKNENHYIGQ 150
    WKNGLMNGNG TMIWSNGNRY DGSWEDGAPK GNGTFRWSDG SFYVGVWSKD 200
    PKEQNGTYYP STSSGNFDWQ PQQVFYVDLS ECVVCTCQRI PVLPSQKMPV 250
    WYGASEQSSS GNRTKNSERP RRRSVDGRVS NGEMELRSNG SGYLQVDDNA 300
    ESTRSSLGPL RIQPAKKQGQ TISKGHKNYE LMLNLQLGIR HSVGRPAPAT 350
    SLDLKASAFD PKEKLWTKFP SEGSKYTPPH QSCEFKWKDY CPVVFRTLRK 400
    LFSVDAADYM LSICGNDALR ELSSPGKSGS FFYLTNDDRY MIKTMKKAET 450
    KVLIRMLPAY YNHVRACENT LVTKFFGLHC VKLTGTAQKK VRFVIMGNLF 500
    CTGHSIHRRF DLKGSSHGRL TTKPESEIDP NTTLKDLDLN FAFRLQKNWF 550
    QEFCRQVDRD CEFLEQERIM DYSLLVGLHF REAAIKDSAT PTSGARTPTG 600
    NSETRLSRAE MDRFLLDASK LASIKLGINM PARVERTARR SDCENQLVGD 650
    PTGEFYDVIV YFGIIDILQD YDISKKLEHA YKSMQYDPTS ISAVDPKQYS 700
    RRFRDFIFRV FVEDA 715
    Length:715
    Mass (Da):81,422
    Last modified:May 1, 2000 - v1
    Checksum:i795D86CEB1FB52E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013483 Genomic DNA. Translation: AAF21206.1.
    CP002686 Genomic DNA. Translation: AEE74625.1.
    BT008595 mRNA. Translation: AAP40421.1.
    RefSeqiNP_187453.1. NM_111675.5.
    UniGeneiAt.40277.

    Genome annotation databases

    EnsemblPlantsiAT3G07960.1; AT3G07960.1; AT3G07960.
    GeneIDi819987.
    KEGGiath:AT3G07960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013483 Genomic DNA. Translation: AAF21206.1 .
    CP002686 Genomic DNA. Translation: AEE74625.1 .
    BT008595 mRNA. Translation: AAP40421.1 .
    RefSeqi NP_187453.1. NM_111675.5.
    UniGenei At.40277.

    3D structure databases

    ProteinModelPortali Q9SFB8.
    SMRi Q9SFB8. Positions 331-707.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 5322. 1 interaction.

    Proteomic databases

    PaxDbi Q9SFB8.
    PRIDEi Q9SFB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G07960.1 ; AT3G07960.1 ; AT3G07960 .
    GeneIDi 819987.
    KEGGi ath:AT3G07960.

    Organism-specific databases

    TAIRi AT3G07960.

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000193875.
    InParanoidi Q9SFB8.
    KOi K00889.
    OMAi QYAIHRR.
    PhylomeDBi Q9SFB8.

    Enzyme and pathway databases

    BioCyci ARA:AT3G07960-MONOMER.
    Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

    Gene expression databases

    Genevestigatori Q9SFB8.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF02493. MORN. 7 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTi SM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
      Mueller-Roeber B., Pical C.
      Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPI5K6_ARATH
    AccessioniPrimary (citable) accession number: Q9SFB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3