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Protein

Phosphatidylinositol 4-phosphate 5-kinase 6

Gene

PIP5K6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • clathrin-dependent endocytosis Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G07960-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 6 (EC:2.7.1.68)
Short name:
AtPIP5K6
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 6
Diphosphoinositide kinase 6
PtdIns(4)P-5-kinase 6
Gene namesi
Name:PIP5K6
Ordered Locus Names:At3g07960
ORF Names:F17A17.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G07960.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: TAIR
  • pollen tube Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854781 – 715Phosphatidylinositol 4-phosphate 5-kinase 6Add BLAST715

Proteomic databases

PaxDbiQ9SFB8.

PTM databases

iPTMnetiQ9SFB8.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SFB8. baseline and differential.
GenevisibleiQ9SFB8. AT.

Interactioni

Protein-protein interaction databases

BioGridi5322. 1 interactor.
STRINGi3702.AT3G07960.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SFB8.
SMRiQ9SFB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 54MORN 1Add BLAST23
Repeati55 – 77MORN 2Add BLAST23
Repeati78 – 100MORN 3Add BLAST23
Repeati101 – 123MORN 4Add BLAST23
Repeati124 – 146MORN 5Add BLAST23
Repeati147 – 169MORN 6Add BLAST23
Repeati170 – 192MORN 7Add BLAST23
Repeati193 – 214MORN 8Add BLAST22
Domaini321 – 711PIPKPROSITE-ProRule annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni671 – 692Activation loopBy similarityAdd BLAST22

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SFB8.
KOiK00889.
OMAiIFRLQKV.
OrthoDBiEOG093602F1.
PhylomeDBiQ9SFB8.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 7 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SFB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAHADDAD DYSRPTGESY HAEKALPSGD FYTGQWRDNL PHGHGKYLWT
60 70 80 90 100
DGCMYVGDWH RGKTMGKGRF SWPSGATYEG DFKNGYMDGK GTYIDSSGDL
110 120 130 140 150
YRGSWVMNLR HGQGTKSYVN GDCYDGEWRR GLQDGHGRYQ WKNENHYIGQ
160 170 180 190 200
WKNGLMNGNG TMIWSNGNRY DGSWEDGAPK GNGTFRWSDG SFYVGVWSKD
210 220 230 240 250
PKEQNGTYYP STSSGNFDWQ PQQVFYVDLS ECVVCTCQRI PVLPSQKMPV
260 270 280 290 300
WYGASEQSSS GNRTKNSERP RRRSVDGRVS NGEMELRSNG SGYLQVDDNA
310 320 330 340 350
ESTRSSLGPL RIQPAKKQGQ TISKGHKNYE LMLNLQLGIR HSVGRPAPAT
360 370 380 390 400
SLDLKASAFD PKEKLWTKFP SEGSKYTPPH QSCEFKWKDY CPVVFRTLRK
410 420 430 440 450
LFSVDAADYM LSICGNDALR ELSSPGKSGS FFYLTNDDRY MIKTMKKAET
460 470 480 490 500
KVLIRMLPAY YNHVRACENT LVTKFFGLHC VKLTGTAQKK VRFVIMGNLF
510 520 530 540 550
CTGHSIHRRF DLKGSSHGRL TTKPESEIDP NTTLKDLDLN FAFRLQKNWF
560 570 580 590 600
QEFCRQVDRD CEFLEQERIM DYSLLVGLHF REAAIKDSAT PTSGARTPTG
610 620 630 640 650
NSETRLSRAE MDRFLLDASK LASIKLGINM PARVERTARR SDCENQLVGD
660 670 680 690 700
PTGEFYDVIV YFGIIDILQD YDISKKLEHA YKSMQYDPTS ISAVDPKQYS
710
RRFRDFIFRV FVEDA
Length:715
Mass (Da):81,422
Last modified:May 1, 2000 - v1
Checksum:i795D86CEB1FB52E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013483 Genomic DNA. Translation: AAF21206.1.
CP002686 Genomic DNA. Translation: AEE74625.1.
BT008595 mRNA. Translation: AAP40421.1.
RefSeqiNP_187453.1. NM_111675.6.
UniGeneiAt.40277.

Genome annotation databases

EnsemblPlantsiAT3G07960.1; AT3G07960.1; AT3G07960.
GeneIDi819987.
GrameneiAT3G07960.1; AT3G07960.1; AT3G07960.
KEGGiath:AT3G07960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013483 Genomic DNA. Translation: AAF21206.1.
CP002686 Genomic DNA. Translation: AEE74625.1.
BT008595 mRNA. Translation: AAP40421.1.
RefSeqiNP_187453.1. NM_111675.6.
UniGeneiAt.40277.

3D structure databases

ProteinModelPortaliQ9SFB8.
SMRiQ9SFB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5322. 1 interactor.
STRINGi3702.AT3G07960.1.

PTM databases

iPTMnetiQ9SFB8.

Proteomic databases

PaxDbiQ9SFB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G07960.1; AT3G07960.1; AT3G07960.
GeneIDi819987.
GrameneiAT3G07960.1; AT3G07960.1; AT3G07960.
KEGGiath:AT3G07960.

Organism-specific databases

TAIRiAT3G07960.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SFB8.
KOiK00889.
OMAiIFRLQKV.
OrthoDBiEOG093602F1.
PhylomeDBiQ9SFB8.

Enzyme and pathway databases

BioCyciARA:AT3G07960-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ9SFB8.

Gene expression databases

ExpressionAtlasiQ9SFB8. baseline and differential.
GenevisibleiQ9SFB8. AT.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 7 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K6_ARATH
AccessioniPrimary (citable) accession number: Q9SFB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.