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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.Curated

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-390471 Association of TriC/CCT with target proteins during biosynthesis
R-ATH-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta1 Publication
Short name:
TCP-1-eta1 Publication
Alternative name(s):
CCT-eta1 Publication
Chaperonin CCT71 Publication
Gene namesi
Name:CCT71 Publication
Ordered Locus Names:At3g11830Imported
ORF Names:F26K24.12Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G11830
TAIRilocus:2081491 AT3G11830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004316642 – 557T-complex protein 1 subunit etaAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SF16
PRIDEiQ9SF16

PTM databases

iPTMnetiQ9SF16

Expressioni

Gene expression databases

ExpressionAtlasiQ9SF16 baseline and differential
GenevisibleiQ9SF16 AT

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:11599560). Interacts with KNAT1 (PubMed:21868675).1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9SF16 8 interactors.
STRINGi3702.AT3G11830.1

Structurei

3D structure databases

ProteinModelPortaliQ9SF16
SMRiQ9SF16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0361 Eukaryota
COG0459 LUCA
HOGENOMiHOG000226730
InParanoidiQ9SF16
KOiK09499
OMAiQGCPNAK
OrthoDBiEOG093606W2
PhylomeDBiQ9SF16

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.102 hits
3.30.260.102 hits
3.50.7.101 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SF16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASMMQPQII LLKEGTDTSQ GKAQLVSNIN ACTAVGDVVR TTLGPRGMDK
60 70 80 90 100
LIHDDKGSVT ISNDGATIMK LLDIVHPAAK ILVDIAKSQD SEVGDGTTTV
110 120 130 140 150
VLLAAEFLKE AKPFIEDGVH AQNLIRSYRT ASTLAIAKVK ELAVSIEGKS
160 170 180 190 200
VEEKKGLLAK CAATTLSSKL IGGEKEFFAT MVVDAVMAIG NDDRLNLIGI
210 220 230 240 250
KKVPGGNMRD SFLVDGVAFK KTFSYAGFEQ QPKKFLNPKI LLLNIELELK
260 270 280 290 300
SEKENAEIRL SDPSQYQSIV DAEWNIIYDK LDKCVESGAK VVLSRLAIGD
310 320 330 340 350
LATQYFADRD IFCAGRVAEE DLNRVAAAAG GTVQTSVNNI IDEVLGTCEI
360 370 380 390 400
FEEKQVGGER FNIFSGCPSG RTATIVLRGG ADQFIEEAER SLHDAIMIVR
410 420 430 440 450
RAVKNSTVVP GGGAIDMEIS KYLRQHSRTI AGKSQLFINS YAKALEVIPR
460 470 480 490 500
QLCDNAGFDA TDVLNKLRQK HAMQSGEGAS YGVDINTGGI ADSFANFVWE
510 520 530 540 550
PAVVKINAIN AATEAACLIL SVDETVKNPK SESAQGDAAG AMGRGRGGGR

GRGMRRR
Length:557
Mass (Da):59,776
Last modified:May 1, 2000 - v1
Checksum:iDC5840417FB62769
GO
Isoform 2 (identifier: Q9SF16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-418: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:555
Mass (Da):59,516
Checksum:iDE8CDDC525FA54B5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057340417 – 418Missing in isoform 2. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016795 Genomic DNA Translation: AAF23199.1
CP002686 Genomic DNA Translation: AEE75105.1
CP002686 Genomic DNA Translation: AEE75106.1
AY070472 mRNA Translation: AAL49938.1
AY102137 mRNA Translation: AAM26704.1
RefSeqiNP_001189863.1, NM_001202934.1 [Q9SF16-2]
NP_187789.1, NM_112016.5 [Q9SF16-1]
UniGeneiAt.23522
At.39684

Genome annotation databases

EnsemblPlantsiAT3G11830.1; AT3G11830.1; AT3G11830 [Q9SF16-1]
AT3G11830.2; AT3G11830.2; AT3G11830 [Q9SF16-2]
GeneIDi820356
GrameneiAT3G11830.1; AT3G11830.1; AT3G11830 [Q9SF16-1]
AT3G11830.2; AT3G11830.2; AT3G11830 [Q9SF16-2]
KEGGiath:AT3G11830

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCPH_ARATH
AccessioniPrimary (citable) accession number: Q9SF16
Secondary accession number(s): F4J7H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 7, 2015
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome