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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.Curated

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-ATH-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta1 Publication
Short name:
TCP-1-eta1 Publication
Alternative name(s):
CCT-eta1 Publication
Chaperonin CCT71 Publication
Gene namesi
Name:CCT71 Publication
Ordered Locus Names:At3g11830Imported
ORF Names:F26K24.12Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G11830.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 557556T-complex protein 1 subunit etaPRO_0000431664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SF16.
PRIDEiQ9SF16.

PTM databases

iPTMnetiQ9SF16.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SF16. baseline and differential.
GenevisibleiQ9SF16. AT.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:11599560). Interacts with KNAT1 (PubMed:21868675).1 Publication1 Publication

Protein-protein interaction databases

IntActiQ9SF16. 8 interactions.
STRINGi3702.AT3G11830.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SF16.
SMRiQ9SF16. Positions 9-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0361. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226730.
InParanoidiQ9SF16.
KOiK09499.
OMAiLCEHFEE.
OrthoDBiEOG093606W2.
PhylomeDBiQ9SF16.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF22. PTHR11353:SF22. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SF16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASMMQPQII LLKEGTDTSQ GKAQLVSNIN ACTAVGDVVR TTLGPRGMDK
60 70 80 90 100
LIHDDKGSVT ISNDGATIMK LLDIVHPAAK ILVDIAKSQD SEVGDGTTTV
110 120 130 140 150
VLLAAEFLKE AKPFIEDGVH AQNLIRSYRT ASTLAIAKVK ELAVSIEGKS
160 170 180 190 200
VEEKKGLLAK CAATTLSSKL IGGEKEFFAT MVVDAVMAIG NDDRLNLIGI
210 220 230 240 250
KKVPGGNMRD SFLVDGVAFK KTFSYAGFEQ QPKKFLNPKI LLLNIELELK
260 270 280 290 300
SEKENAEIRL SDPSQYQSIV DAEWNIIYDK LDKCVESGAK VVLSRLAIGD
310 320 330 340 350
LATQYFADRD IFCAGRVAEE DLNRVAAAAG GTVQTSVNNI IDEVLGTCEI
360 370 380 390 400
FEEKQVGGER FNIFSGCPSG RTATIVLRGG ADQFIEEAER SLHDAIMIVR
410 420 430 440 450
RAVKNSTVVP GGGAIDMEIS KYLRQHSRTI AGKSQLFINS YAKALEVIPR
460 470 480 490 500
QLCDNAGFDA TDVLNKLRQK HAMQSGEGAS YGVDINTGGI ADSFANFVWE
510 520 530 540 550
PAVVKINAIN AATEAACLIL SVDETVKNPK SESAQGDAAG AMGRGRGGGR

GRGMRRR
Length:557
Mass (Da):59,776
Last modified:May 1, 2000 - v1
Checksum:iDC5840417FB62769
GO
Isoform 2 (identifier: Q9SF16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-418: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:555
Mass (Da):59,516
Checksum:iDE8CDDC525FA54B5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei417 – 4182Missing in isoform 2. VSP_057340

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016795 Genomic DNA. Translation: AAF23199.1.
CP002686 Genomic DNA. Translation: AEE75105.1.
CP002686 Genomic DNA. Translation: AEE75106.1.
AY070472 mRNA. Translation: AAL49938.1.
AY102137 mRNA. Translation: AAM26704.1.
RefSeqiNP_001189863.1. NM_001202934.1. [Q9SF16-2]
NP_187789.1. NM_112016.4. [Q9SF16-1]
UniGeneiAt.23522.
At.39684.

Genome annotation databases

EnsemblPlantsiAT3G11830.1; AT3G11830.1; AT3G11830. [Q9SF16-1]
AT3G11830.2; AT3G11830.2; AT3G11830. [Q9SF16-2]
GeneIDi820356.
KEGGiath:AT3G11830.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016795 Genomic DNA. Translation: AAF23199.1.
CP002686 Genomic DNA. Translation: AEE75105.1.
CP002686 Genomic DNA. Translation: AEE75106.1.
AY070472 mRNA. Translation: AAL49938.1.
AY102137 mRNA. Translation: AAM26704.1.
RefSeqiNP_001189863.1. NM_001202934.1. [Q9SF16-2]
NP_187789.1. NM_112016.4. [Q9SF16-1]
UniGeneiAt.23522.
At.39684.

3D structure databases

ProteinModelPortaliQ9SF16.
SMRiQ9SF16. Positions 9-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9SF16. 8 interactions.
STRINGi3702.AT3G11830.1.

PTM databases

iPTMnetiQ9SF16.

Proteomic databases

PaxDbiQ9SF16.
PRIDEiQ9SF16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G11830.1; AT3G11830.1; AT3G11830. [Q9SF16-1]
AT3G11830.2; AT3G11830.2; AT3G11830. [Q9SF16-2]
GeneIDi820356.
KEGGiath:AT3G11830.

Organism-specific databases

TAIRiAT3G11830.

Phylogenomic databases

eggNOGiKOG0361. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226730.
InParanoidiQ9SF16.
KOiK09499.
OMAiLCEHFEE.
OrthoDBiEOG093606W2.
PhylomeDBiQ9SF16.

Enzyme and pathway databases

ReactomeiR-ATH-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-ATH-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiQ9SF16.

Gene expression databases

ExpressionAtlasiQ9SF16. baseline and differential.
GenevisibleiQ9SF16. AT.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF22. PTHR11353:SF22. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPH_ARATH
AccessioniPrimary (citable) accession number: Q9SF16
Secondary accession number(s): F4J7H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 7, 2015
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.