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Q9SEP4 (CHSY_ARAAL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismArabis alpina (Alpine rock-cress)
Taxonomic identifier50452 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeArabideaeArabis

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Chalcone synthase
PRO_0000215953

Sites

Active site1651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9SEP4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 103B92D7BDB20001

FASTA39142,658
        10         20         30         40         50         60 
MAPSLEEIRK AQRADGPAGI LGIGTANPPN HVLQAEYPDY YFRITNSDHM TDLKEKFKRM 

        70         80         90        100        110        120 
CDKSMIRKRH MHLTEEFLKE NPKMCAYMAP SLDTRQDIVV VEVPKLGKEA AVKAIKEWGQ 

       130        140        150        160        170        180 
PKSKITHVVF CTTSGVDMPG ADYQLTKLLG LRPSVKRLMM YQQGCFAGGT VLRLAKDLAE 

       190        200        210        220        230        240 
NNRGARVLVV CSEITAVTFR GPSDTHLDSL VGQALFSDGA AALIVGSDPD TSVGEKPIFE 

       250        260        270        280        290        300 
MVSAAQTILP DSDGAIDGHL REVGLTFHLL KDVPGLISKN IEKSLDEAFK PLGISDWNSL 

       310        320        330        340        350        360 
FWIAHPGGPA ILDQVEIKLG LKAEKMRATR HVLSEYGNMS SACVLFILDE MRKKSAKDGA 

       370        380        390 
ATTGEGLEWG VLFGFGPGLT VETVVLHSVP L 

« Hide

References

[1]"Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae)."
Koch M.A., Haubold B., Mitchell-Olds T.
Mol. Biol. Evol. 17:1483-1498(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AlpAF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF112083 Genomic DNA. Translation: AAF23558.1.

3D structure databases

ProteinModelPortalQ9SEP4.
SMRQ9SEP4. Positions 4-391.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_ARAAL
AccessionPrimary (citable) accession number: Q9SEP4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways