Q9SEK2 (HXK1_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase-1
EC=2.7.1.1

Alternative name(s):
NtHxK1

Gene names

Name:

HXK1

Organism

Nicotiana tabacum (Common tobacco)

Taxonomic identifier

4097 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol By similarity.
Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Subcellular location	Plastid › chloroplast outer membrane; Single-pass membrane protein Probable.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Chloroplast Membrane Plastid Plastid outer membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Hexokinase-1		PRO_0000197618
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Nucleotide binding	101 – 106	6	ATP Potential
	Region	171 – 197	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9SEK2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 05F6825652C28F70	FASTA	497	53,740
	10 20 30 40 50 60 MKKATVGAAV IGAATVCAVA ALIVNHRMRK SSKWARAMAI LREFEEKCGT PDAKLKQVAD 70 80 90 100 110 120 AMTVEMHAGL ASEGGSKLKM LITYVDNLPT GDEAGVFYAL DLGGTNFRVL RVQLGGKDGG 130 140 150 160 170 180 IVHQEFAEAS IPPNLMVGTS EALFDYIAAE LAKFVNEEGE KFQQPPGKQR ELGFTFSFPV 190 200 210 220 230 240 MQTSINSGTI MRWTKGFSID DAVGQDVVGE LAKAMKRKGV DMRVSALVND TVGTLAGGKY 250 260 270 280 290 300 THNDVAVAVI LGTGTNAAYV ERVQAIPKWH GPVPKSGEMV INMEWGNFRS SHLPLTQYDH 310 320 330 340 350 360 ALDTNSLNPG DQIFEKMTSG MYLGEILRRV LLRVAEEAGI FGDEVPPKLK SPFVLRTPDM 370 380 390 400 410 420 SAMHHDASSD LRVVGDKLKD ILEISNTSLK TRRLVIELCN IVATRGARLA AAGVLGILKK 430 440 450 460 470 480 MGRDTPRQGG LEKTVVAMDG GLYEHYTEYR MCLENTLKEL LGDELATSIV FEHSNDGSGI 490 GAALLAASNS MYLEDKS

References

[1]	"Spinach hexokinase I is located in the outer envelope membrane of plastids." Wiese A., Groener F., Sonnewald U., Deppner H., Lerchl J., Fluegge U.I., Weber A. FEBS Lett. 461:13-18(1999) [PubMed: 10561488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF118133 mRNA. Translation: AAF18585.1.
3D structure databases
ProteinModelPortal	Q9SEK2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK1_TOBAC

Accession

Primary (citable) accession number: Q9SEK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	September 21, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program