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Protein

Transcription factor WER

Gene

WER

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi41 – 65H-T-H motifPROSITE-ProRule annotationAdd BLAST25
DNA bindingi93 – 116H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell fate commitment Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • root hair cell differentiation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor WER
Alternative name(s):
Myb-related protein 66
Short name:
AtMYB66
Protein WEREWOLF
Gene namesi
Name:WER
Synonyms:MYB66
Ordered Locus Names:At5g14750
ORF Names:T9L3.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G14750.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852731 – 203Transcription factor WERAdd BLAST203

Proteomic databases

PaxDbiQ9SEI0.

Expressioni

Tissue specificityi

Restricted to roots and hypocotyl. Specifically expressed in root non-hair developing cells (atrichoblasts) at the N position. Also present in lateral root cap cells. In hypocotyls, expressed within files of epidermal cells located outside a single cortical cell equivalent to roots N cells (at protein level).3 Publications

Inductioni

Transcriptional activation correlates with reduced histone acetylation on H3 and H4 mediated by HDA18 in N cells. Repressed by CPC in hair cells (H position).2 Publications

Gene expression databases

ExpressionAtlasiQ9SEI0. baseline and differential.
GenevisibleiQ9SEI0. AT.

Interactioni

Subunit structurei

Interacts with GL3, BHLH2/EGL3/MYC146 and BHLH12/MYC1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLH2Q9CAD04EBI-533373,EBI-533398
GL3Q9FN693EBI-533373,EBI-533348

Protein-protein interaction databases

BioGridi16604. 5 interactors.
IntActiQ9SEI0. 5 interactors.
STRINGi3702.AT5G14750.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SEI0.
SMRiQ9SEI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 65HTH myb-type 1PROSITE-ProRule annotationAdd BLAST53
Domaini66 – 120HTH myb-type 2PROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000237600.
InParanoidiQ9SEI0.
KOiK09422.
OMAiYLSSLWV.
OrthoDBiEOG09360LV2.
PhylomeDBiQ9SEI0.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SEI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKVSSSGD EGNNEYKKGL WTVEEDKILM DYVKAHGKGH WNRIAKKTGL
60 70 80 90 100
KRCGKSCRLR WMNYLSPNVK RGNFTEQEED LIIRLHKLLG NRWSLIAKRV
110 120 130 140 150
PGRTDNQVKN YWNTHLSKKL GIKDQKTKQS NGDIVYQINL PNPTETSEET
160 170 180 190 200
KISNIVDNNN ILGDEIQEDH QGSNYLSSLW VHEDEFELST LTNMMDFIDG

HCF
Length:203
Mass (Da):23,569
Last modified:May 1, 2000 - v1
Checksum:iEFAB8A342F0FB66F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134I → M in AAC83622 (PubMed:9839469).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126399 Genomic DNA. Translation: AAF18939.1.
AY519623 mRNA. Translation: AAS10093.1.
AL391149 Genomic DNA. Translation: CAC01874.1.
CP002688 Genomic DNA. Translation: AED92073.1.
BT026346 mRNA. Translation: ABH04453.1.
AF062900 mRNA. Translation: AAC83622.1.
PIRiT51420.
T51672.
RefSeqiNP_196979.1. NM_121479.3.
UniGeneiAt.28680.

Genome annotation databases

EnsemblPlantsiAT5G14750.1; AT5G14750.1; AT5G14750.
GeneIDi831327.
GrameneiAT5G14750.1; AT5G14750.1; AT5G14750.
KEGGiath:AT5G14750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126399 Genomic DNA. Translation: AAF18939.1.
AY519623 mRNA. Translation: AAS10093.1.
AL391149 Genomic DNA. Translation: CAC01874.1.
CP002688 Genomic DNA. Translation: AED92073.1.
BT026346 mRNA. Translation: ABH04453.1.
AF062900 mRNA. Translation: AAC83622.1.
PIRiT51420.
T51672.
RefSeqiNP_196979.1. NM_121479.3.
UniGeneiAt.28680.

3D structure databases

ProteinModelPortaliQ9SEI0.
SMRiQ9SEI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16604. 5 interactors.
IntActiQ9SEI0. 5 interactors.
STRINGi3702.AT5G14750.1.

Proteomic databases

PaxDbiQ9SEI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G14750.1; AT5G14750.1; AT5G14750.
GeneIDi831327.
GrameneiAT5G14750.1; AT5G14750.1; AT5G14750.
KEGGiath:AT5G14750.

Organism-specific databases

TAIRiAT5G14750.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000237600.
InParanoidiQ9SEI0.
KOiK09422.
OMAiYLSSLWV.
OrthoDBiEOG09360LV2.
PhylomeDBiQ9SEI0.

Miscellaneous databases

PROiQ9SEI0.

Gene expression databases

ExpressionAtlasiQ9SEI0. baseline and differential.
GenevisibleiQ9SEI0. AT.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWER_ARATH
AccessioniPrimary (citable) accession number: Q9SEI0
Secondary accession number(s): Q9ZTD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is called 'Werewolf' because plants lacking WER exhibit hairy roots.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.