UniProtKB - Q9SE94 (MTHR1_MAIZE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Methylenetetrahydrofolate reductase 1
Gene
N/A
Organism
Zea mays (Maize)
Status
Functioni
The probable reversibility of the MTHFR reaction in plants suggests that they can metabolize the methyl group of 5,10-methylenetetrahydrofolate to serine, sugars and starch.1 Publication
Catalytic activityi
5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.
Cofactori
FADBy similarity
Enzyme regulationi
Plant MTHFRs strongly prefer NADH over NADPH. Not inhibited by methionine or S-adenosylmethionine.1 Publication
: tetrahydrofolate interconversion Pathwayi
This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 21 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 81 | FADBy similarity | 1 | |
Binding sitei | 113 | SubstrateBy similarity | 1 | |
Binding sitei | 153 | FADBy similarity | 1 | |
Binding sitei | 175 | FADBy similarity | 1 | |
Binding sitei | 182 | FADBy similarity | 1 | |
Binding sitei | 193 | SubstrateBy similarity | 1 | |
Binding sitei | 285 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 26 | NADBy similarity | 6 | |
Nucleotide bindingi | 52 – 53 | NAD and FADBy similarity | 2 | |
Nucleotide bindingi | 111 – 113 | FADBy similarity | 3 | |
Nucleotide bindingi | 157 – 160 | FADBy similarity | 4 |
GO - Molecular functioni
- methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC
GO - Biological processi
- methionine metabolic process Source: InterPro
- tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD |
Enzyme and pathway databases
BRENDAi | 1.5.1.20. 6752. |
UniPathwayi | UPA00193. |
Names & Taxonomyi
Protein namesi | |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 146840. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190251 | 1 – 593 | Methylenetetrahydrofolate reductase 1Add BLAST | 593 |
Proteomic databases
PaxDbi | Q9SE94. |
PRIDEi | Q9SE94. |
ProMEXi | Q9SE94. |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SE94. baseline and differential. |
Genevisiblei | Q9SE94. ZM. |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
STRINGi | 4577.GRMZM2G347056_P01. |
Structurei
3D structure databases
ProteinModelPortali | Q9SE94. |
SMRi | Q9SE94. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the methylenetetrahydrofolate reductase family.Curated
Phylogenomic databases
eggNOGi | KOG0564. Eukaryota. COG0685. LUCA. |
HOGENOMi | HOG000246234. |
KOi | K00297. |
OMAi | MESGDKW. |
OrthoDBi | EOG093604CD. |
Family and domain databases
CDDi | cd00537. MTHFR. 1 hit. |
InterProi | View protein in InterPro IPR029041. FAD-linked_oxidoreductase-like. IPR004621. Fadh2_euk. IPR003171. Mehydrof_redctse. |
Pfami | View protein in Pfam PF02219. MTHFR. 1 hit. |
SUPFAMi | SSF51730. SSF51730. 1 hit. |
TIGRFAMsi | TIGR00677. fadh2_euk. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9SE94-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVIEKILEA AGDGRTAFSF EYFPPKTEEG VENLFERMDR MVAHGPSFCD
60 70 80 90 100
ITWGAGGSTA DLTLEIANRM QNMVCVETMM HLTCTNMPVE KIDHALETIK
110 120 130 140 150
SNGIQNVLAL RGDPPHGQDK FVQVEGGFAC ALDLVQHIRA KYGDYFGITV
160 170 180 190 200
AGYPEAHPDA IQGEGGATLE AYSNDLAYLK RKVDAGADLI VTQLFYDTDI
210 220 230 240 250
FLKFVNDCRQ IGITCPIVPG IMPINNYKGF LRMTGFCKTK IPSEITAALD
260 270 280 290 300
PIKDNEEAVR QYGIHLGTEM CKKILATGIK TLHLYTLNMD KSAIGILMNL
310 320 330 340 350
GLIEESKVSR PLPWRPATNV FRVKEDVRPI FWANRPKSYL KRTLGWDQYP
360 370 380 390 400
HGRWGDSRNP SYGALTDHQF TRPRGRGKKL QEEWAVPLKS VEDISERFTN
410 420 430 440 450
FCQGKLTSSP WSELDGLQPE TKIIDDQLVN INQKGFLTIN SQPAVNGEKS
460 470 480 490 500
DSPTVGWGGP GGYVYQKAYL EFFCAKEKLD QLIEKIKAFP SLTYIAVNKD
510 520 530 540 550
GETFSNISPN AVNAVTWGVF PGKEIIQPTV VDHASFMVWK DEAFEIWTRG
560 570 580 590
WGCMFPEGDS SRELLEKVQK TYYLVSLVDN DYVQGDLFAA FKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF174486 mRNA. Translation: AAD51733.1. |
RefSeqi | NP_001104947.1. NM_001111477.2. |
UniGenei | Zm.475. |
Genome annotation databases
EnsemblPlantsi | Zm00001d034602_T001; Zm00001d034602_P001; Zm00001d034602. |
GeneIDi | 541794. |
Gramenei | Zm00001d034602_T001; Zm00001d034602_P001; Zm00001d034602. |
KEGGi | zma:541794. |
Similar proteinsi
Entry informationi
Entry namei | MTHR1_MAIZE | |
Accessioni | Q9SE94Primary (citable) accession number: Q9SE94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |