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Q9SE26 (ACEA_DENCR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL
OrganismDendrobium crumenatum (Tropical pigeon orchid)
Taxonomic identifier51096 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Asparagales › Orchidaceae › Epidendroideae › Dendrobiinae › Dendrobium

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Glyoxysome.

Developmental stage

Expressed maximally during postgerminative growth.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 574574Isocitrate lyase
PRO_0000068805

Regions

Motif572 – 5743Microbody targeting signal Potential

Sites

Active site2121 Probable

Sequences

Sequence LengthMass (Da)Tools
Q9SE26 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0B568ADE3248DE2E

FASTA57463,993
        10         20         30         40         50         60 
MASSSVPPMI TEEEARFEAE VSAVESWWRT DRFRLTRRPY SARDVVSLRG TLHHSYASDQ 

        70         80         90        100        110        120 
MAKKLWRTLK SHQSAGTASR TFGALDPVQV TMMAKHLDTI YVSGWQCSST HTATNEPGPD 

       130        140        150        160        170        180 
LADYPYNTVP NKVEHLFFAQ LYHDRKQHEA RVSMTREQRA KTPYVDYLRP IIADGDTGFG 

       190        200        210        220        230        240 
GATATVKLCK LFVERGAAGV HIEDQSSVTK KCGHMAGKVL VAVSEHINRL VAARLQFDVM 

       250        260        270        280        290        300 
GVETVLVART DAVAATLIQS NVDLRDHQFI LGATNPDFKR RSLAAVLSAA MAAGKTGAVL 

       310        320        330        340        350        360 
QAIEDDWLSR AGLMTFSDAV INGINRQNLP EYEKQRRLNE WAAATEYSKC VSNEQGREIA 

       370        380        390        400        410        420 
ERLGAGEIFW DWDIARTREG FYRFRGSVEA AVVRGRAFAP HADLIWMETS SPDLVECGKF 

       430        440        450        460        470        480 
AQGMKASHPE IMLAYNLSPS FNWDAAGMTD EEMRDFIPRI AKMGFCWQFI TLGGFHADAL 

       490        500        510        520        530        540 
VTDTFAREFA KQGMLAYVER IQREERNNGV DTLAHQKWSG ANYYDRYLKT VQGGISSTAA 

       550        560        570 
MGKGVTEEQF KEESRTGTRG LDRGGITVNA KSRL

« Hide

References

[1]"Sequence analysis of DcrIcl, an isocitrate lyase gene from the tropical orchid, Dendrobium crumenatum."
Vellupillai M., Goh C.-J., Swarup S.
Plant Gene Register PGR99-178
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF193815 mRNA. Translation: AAF04598.1.

3D structure databases

ProteinModelPortalQ9SE26.
SMRQ9SE26. Positions 8-534.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_DENCR
AccessionPrimary (citable) accession number: Q9SE26
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 6, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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