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Protein

V-type proton ATPase subunit C

Gene

VHA-C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-1222556. ROS, RNS production in response to bacteria.
R-ATH-77387. Insulin receptor recycling.
R-ATH-917977. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.5. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C
Short name:
V-ATPase subunit C
Alternative name(s):
Vacuolar H(+)-ATPase subunit C
Vacuolar proton pump subunit C
Gene namesi
Name:VHA-C
Synonyms:DET3, VATC
Ordered Locus Names:At1g12840
ORF Names:F13K23.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G12840.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • Golgi apparatus Source: TAIR
  • plant-type vacuole Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
  • vacuolar proton-transporting V-type ATPase, V1 domain Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093551 – 375V-type proton ATPase subunit CAdd BLAST375

Post-translational modificationi

Phosphorylated on Ser/Thr residues by WNK8.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SDS7.
PRIDEiQ9SDS7.

PTM databases

iPTMnetiQ9SDS7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SDS7. baseline and differential.
GenevisibleiQ9SDS7. AT.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

Binary interactionsi

WithEntry#Exp.IntActNotes
WNK8Q944Q04EBI-1794418,EBI-4441446

Protein-protein interaction databases

BioGridi23080. 10 interactors.
IntActiQ9SDS7. 5 interactors.
MINTiMINT-1772204.
STRINGi3702.AT1G12840.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SDS7.
SMRiQ9SDS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909. Eukaryota.
COG5127. LUCA.
HOGENOMiHOG000207528.
InParanoidiQ9SDS7.
KOiK02148.
OMAiNSEYLIT.
OrthoDBiEOG09360FED.
PhylomeDBiQ9SDS7.

Family and domain databases

CDDicd14785. V-ATPase_C. 1 hit.
InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 1 hit.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]
SUPFAMiSSF118203. SSF118203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SDS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRYWVVSL PVKDSASSLW NRLQEQISKH SFDTPVYRFN IPNLRVGTLD
60 70 80 90 100
SLLALGDDLL KSNSFVEGVS QKIRRQIEEL ERISGVESNA LTVDGVPVDS
110 120 130 140 150
YLTRFVWDEA KYPTMSPLKE VVDNIQSQVA KIEDDLKVRV AEYNNIRGQL
160 170 180 190 200
NAINRKQSGS LAVRDLSNLV KPEDIVESEH LVTLLAVVPK YSQKDWLACY
210 220 230 240 250
ETLTDYVVPR SSKKLFEDNE YALYTVTLFT RVADNFRIAA REKGFQVRDF
260 270 280 290 300
EQSVEAQETR KQELAKLVQD QESLRSSLLQ WCYTSYGEVF SSWMHFCAVR
310 320 330 340 350
TFAESIMRYG LPPAFLACVL SPAVKSEKKV RSILERLCDS TNSLYWKSEE
360 370
DAGAMAGLAG DSETHPYVSF TINLA
Length:375
Mass (Da):42,619
Last modified:May 1, 2000 - v1
Checksum:iA50F11D168F31C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208261 mRNA. Translation: AAF20146.1.
AC012187 Genomic DNA. Translation: AAF78489.1.
CP002684 Genomic DNA. Translation: AEE28936.1.
AF334725 mRNA. Translation: AAG50103.1.
AY059872 mRNA. Translation: AAL24354.1.
AY093334 mRNA. Translation: AAM13333.1.
PIRiT52300.
RefSeqiNP_563916.1. NM_101154.4.
UniGeneiAt.21380.

Genome annotation databases

EnsemblPlantsiAT1G12840.1; AT1G12840.1; AT1G12840.
GeneIDi837840.
GrameneiAT1G12840.1; AT1G12840.1; AT1G12840.
KEGGiath:AT1G12840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208261 mRNA. Translation: AAF20146.1.
AC012187 Genomic DNA. Translation: AAF78489.1.
CP002684 Genomic DNA. Translation: AEE28936.1.
AF334725 mRNA. Translation: AAG50103.1.
AY059872 mRNA. Translation: AAL24354.1.
AY093334 mRNA. Translation: AAM13333.1.
PIRiT52300.
RefSeqiNP_563916.1. NM_101154.4.
UniGeneiAt.21380.

3D structure databases

ProteinModelPortaliQ9SDS7.
SMRiQ9SDS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23080. 10 interactors.
IntActiQ9SDS7. 5 interactors.
MINTiMINT-1772204.
STRINGi3702.AT1G12840.1.

Protein family/group databases

TCDBi3.A.2.2.5. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiQ9SDS7.

Proteomic databases

PaxDbiQ9SDS7.
PRIDEiQ9SDS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G12840.1; AT1G12840.1; AT1G12840.
GeneIDi837840.
GrameneiAT1G12840.1; AT1G12840.1; AT1G12840.
KEGGiath:AT1G12840.

Organism-specific databases

TAIRiAT1G12840.

Phylogenomic databases

eggNOGiKOG2909. Eukaryota.
COG5127. LUCA.
HOGENOMiHOG000207528.
InParanoidiQ9SDS7.
KOiK02148.
OMAiNSEYLIT.
OrthoDBiEOG09360FED.
PhylomeDBiQ9SDS7.

Enzyme and pathway databases

ReactomeiR-ATH-1222556. ROS, RNS production in response to bacteria.
R-ATH-77387. Insulin receptor recycling.
R-ATH-917977. Transferrin endocytosis and recycling.

Miscellaneous databases

PROiQ9SDS7.

Gene expression databases

ExpressionAtlasiQ9SDS7. baseline and differential.
GenevisibleiQ9SDS7. AT.

Family and domain databases

CDDicd14785. V-ATPase_C. 1 hit.
InterProiIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERiPTHR10137. PTHR10137. 1 hit.
PfamiPF03223. V-ATPase_C. 1 hit.
[Graphical view]
SUPFAMiSSF118203. SSF118203. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATC_ARATH
AccessioniPrimary (citable) accession number: Q9SDS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.