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Protein

V-type proton ATPase subunit C

Gene

VHA-C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • unidimensional cell growth Source: TAIR

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-1222556 ROS, RNS production in phagocytes
R-ATH-77387 Insulin receptor recycling
R-ATH-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.5 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C
Short name:
V-ATPase subunit C
Alternative name(s):
Vacuolar H(+)-ATPase subunit C
Vacuolar proton pump subunit C
Gene namesi
Name:VHA-C
Synonyms:DET3, VATC
Ordered Locus Names:At1g12840
ORF Names:F13K23.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G12840
TAIRilocus:2010386 AT1G12840

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093551 – 375V-type proton ATPase subunit CAdd BLAST375

Post-translational modificationi

Phosphorylated on Ser/Thr residues by WNK8.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SDS7
PRIDEiQ9SDS7

PTM databases

iPTMnetiQ9SDS7

Expressioni

Gene expression databases

ExpressionAtlasiQ9SDS7 baseline and differential
GenevisibleiQ9SDS7 AT

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

Binary interactionsi

WithEntry#Exp.IntActNotes
WNK8Q944Q04EBI-1794418,EBI-4441446

Protein-protein interaction databases

BioGridi23080, 10 interactors
IntActiQ9SDS7, 5 interactors
MINTiQ9SDS7
STRINGi3702.AT1G12840.1

Structurei

3D structure databases

ProteinModelPortaliQ9SDS7
SMRiQ9SDS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
HOGENOMiHOG000207528
InParanoidiQ9SDS7
KOiK02148
OMAiIYRRTEY
OrthoDBiEOG09360FED
PhylomeDBiQ9SDS7

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SDS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRYWVVSL PVKDSASSLW NRLQEQISKH SFDTPVYRFN IPNLRVGTLD
60 70 80 90 100
SLLALGDDLL KSNSFVEGVS QKIRRQIEEL ERISGVESNA LTVDGVPVDS
110 120 130 140 150
YLTRFVWDEA KYPTMSPLKE VVDNIQSQVA KIEDDLKVRV AEYNNIRGQL
160 170 180 190 200
NAINRKQSGS LAVRDLSNLV KPEDIVESEH LVTLLAVVPK YSQKDWLACY
210 220 230 240 250
ETLTDYVVPR SSKKLFEDNE YALYTVTLFT RVADNFRIAA REKGFQVRDF
260 270 280 290 300
EQSVEAQETR KQELAKLVQD QESLRSSLLQ WCYTSYGEVF SSWMHFCAVR
310 320 330 340 350
TFAESIMRYG LPPAFLACVL SPAVKSEKKV RSILERLCDS TNSLYWKSEE
360 370
DAGAMAGLAG DSETHPYVSF TINLA
Length:375
Mass (Da):42,619
Last modified:May 1, 2000 - v1
Checksum:iA50F11D168F31C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208261 mRNA Translation: AAF20146.1
AC012187 Genomic DNA Translation: AAF78489.1
CP002684 Genomic DNA Translation: AEE28936.1
AF334725 mRNA Translation: AAG50103.1
AY059872 mRNA Translation: AAL24354.1
AY093334 mRNA Translation: AAM13333.1
PIRiT52300
RefSeqiNP_563916.1, NM_101154.4
UniGeneiAt.21380

Genome annotation databases

EnsemblPlantsiAT1G12840.1; AT1G12840.1; AT1G12840
GeneIDi837840
GrameneiAT1G12840.1; AT1G12840.1; AT1G12840
KEGGiath:AT1G12840

Similar proteinsi

Entry informationi

Entry nameiVATC_ARATH
AccessioniPrimary (citable) accession number: Q9SDS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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