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Q9SD12 (P2C46_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 46

Short name=AtPP2C46
EC=3.1.3.16
Gene names
Ordered Locus Names:At3g51370
ORF Names:F26O13.10
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence BX823319 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentplasma membrane

Inferred from direct assay PubMed 17317660. Source: TAIR

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9SD12-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9SD12-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-105: HGGPETSRFVNDHLFQHLKR → MHTRLQTNRAETKILFEFSG
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 379359Probable protein phosphatase 2C 46
PRO_0000367970

Regions

Domain79 – 325247PP2C-like

Sites

Metal binding841Manganese 1 By similarity
Metal binding841Manganese 2 By similarity
Metal binding851Manganese 1; via carbonyl oxygen By similarity
Metal binding2851Manganese 2 By similarity
Metal binding3441Manganese 2 By similarity

Natural variations

Alternative sequence1 – 8585Missing in isoform 2.
VSP_036772
Alternative sequence86 – 10520HGGPE…QHLKR → MHTRLQTNRAETKILFEFSG in isoform 2.
VSP_036773

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 342934B0CA4CB760

FASTA37942,179
        10         20         30         40         50         60 
MLSTLMKLLS ACLWPSSSSG KSSDSTGKQD GLLWYKDFGQ HLVGEFSMAV VQANNLLEDQ 

        70         80         90        100        110        120 
SQVESGPLST LDSGPYGTFI GIYDGHGGPE TSRFVNDHLF QHLKRFAAEQ ASMSVDVIKK 

       130        140        150        160        170        180 
AYEATEEGFL GVVTKQWPTK PQIAAVGSCC LVGVICGGML YIANVGDSRA VLGRAMKATG 

       190        200        210        220        230        240 
EVIALQLSAE HNVSIESVRQ EMHSLHPDDS HIVMLKHNVW RVKGLIQISR SIGDVYLKKA 

       250        260        270        280        290        300 
EFNKEPLYTK YRIREPFKRP ILSGEPTITE HEIQPQDKFL IFASDGLWEQ MSNQEAVDIV 

       310        320        330        340        350        360 
QNHPRNGIAR RLVKMALQEA AKKREMRYSD LKKIERGVRR HFHDDITVVI IFLDTNQVSS 

       370 
VKGPPLSIRG GGMTFPKKI 

« Hide

Isoform 2 [UniParc].

Checksum: 418C3262DBAB0261
Show »

FASTA29433,107

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[4]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL133452 Genomic DNA. Translation: CAB63001.1.
CP002686 Genomic DNA. Translation: AEE78784.1.
CP002686 Genomic DNA. Translation: AEE78785.1.
BX823319 mRNA. No translation available.
PIRT45768.
RefSeqNP_566949.2. NM_114996.3. [Q9SD12-1]
NP_974411.1. NM_202682.2. [Q9SD12-2]
UniGeneAt.21696.

3D structure databases

ProteinModelPortalQ9SD12.
SMRQ9SD12. Positions 79-362.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9SD12.
PRIDEQ9SD12.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G51370.1; AT3G51370.1; AT3G51370. [Q9SD12-1]
GeneID824300.
KEGGath:AT3G51370.

Organism-specific databases

TAIRAT3G51370.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000238703.
InParanoidQ9SD12.
OMAVHELQPH.
PhylomeDBQ9SD12.

Enzyme and pathway databases

BioCycARA:AT3G51370-MONOMER.
ARA:GQT-49-MONOMER.

Gene expression databases

GenevestigatorQ9SD12.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C46_ARATH
AccessionPrimary (citable) accession number: Q9SD12
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names