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Protein

Probable protein phosphatase 2C 46

Gene

At3g51370

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Manganese 1By similarity1
Metal bindingi84Manganese 2By similarity1
Metal bindingi85Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi285Manganese 2By similarity1
Metal bindingi344Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 46 (EC:3.1.3.16)
Short name:
AtPP2C46
Gene namesi
Ordered Locus Names:At3g51370
ORF Names:F26O13.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G51370
TAIRilocus:2081770 AT3G51370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000036797021 – 379Probable protein phosphatase 2C 46Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SD12

Expressioni

Gene expression databases

ExpressionAtlasiQ9SD12 baseline and differential
GenevisibleiQ9SD12 AT

Interactioni

Protein-protein interaction databases

BioGridi9618, 1 interactor
STRINGi3702.AT3G51370.1

Structurei

3D structure databases

ProteinModelPortaliQ9SD12
SMRiQ9SD12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 353PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0700 Eukaryota
COG0631 LUCA
HOGENOMiHOG000238703
InParanoidiQ9SD12
OMAiAQCDARY
OrthoDBiEOG09360D2T
PhylomeDBiQ9SD12

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SD12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSTLMKLLS ACLWPSSSSG KSSDSTGKQD GLLWYKDFGQ HLVGEFSMAV
60 70 80 90 100
VQANNLLEDQ SQVESGPLST LDSGPYGTFI GIYDGHGGPE TSRFVNDHLF
110 120 130 140 150
QHLKRFAAEQ ASMSVDVIKK AYEATEEGFL GVVTKQWPTK PQIAAVGSCC
160 170 180 190 200
LVGVICGGML YIANVGDSRA VLGRAMKATG EVIALQLSAE HNVSIESVRQ
210 220 230 240 250
EMHSLHPDDS HIVMLKHNVW RVKGLIQISR SIGDVYLKKA EFNKEPLYTK
260 270 280 290 300
YRIREPFKRP ILSGEPTITE HEIQPQDKFL IFASDGLWEQ MSNQEAVDIV
310 320 330 340 350
QNHPRNGIAR RLVKMALQEA AKKREMRYSD LKKIERGVRR HFHDDITVVI
360 370
IFLDTNQVSS VKGPPLSIRG GGMTFPKKI
Length:379
Mass (Da):42,179
Last modified:May 1, 2000 - v1
Checksum:i342934B0CA4CB760
GO
Isoform 2 (identifier: Q9SD12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-105: HGGPETSRFVNDHLFQHLKR → MHTRLQTNRAETKILFEFSG

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:294
Mass (Da):33,107
Checksum:i418C3262DBAB0261
GO

Sequence cautioni

The sequence BX823319 differs from that shown. Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367721 – 85Missing in isoform 2. CuratedAdd BLAST85
Alternative sequenceiVSP_03677386 – 105HGGPE…QHLKR → MHTRLQTNRAETKILFEFSG in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133452 Genomic DNA Translation: CAB63001.1
CP002686 Genomic DNA Translation: AEE78784.1
CP002686 Genomic DNA Translation: AEE78785.1
CP002686 Genomic DNA Translation: ANM65136.1
BX823319 mRNA No translation available.
PIRiT45768
RefSeqiNP_001327130.1, NM_001339513.1 [Q9SD12-1]
NP_566949.2, NM_114996.4 [Q9SD12-1]
NP_974411.1, NM_202682.2 [Q9SD12-2]
UniGeneiAt.21696

Genome annotation databases

EnsemblPlantsiAT3G51370.1; AT3G51370.1; AT3G51370 [Q9SD12-1]
AT3G51370.2; AT3G51370.2; AT3G51370 [Q9SD12-2]
AT3G51370.3; AT3G51370.3; AT3G51370 [Q9SD12-1]
GeneIDi824300
GrameneiAT3G51370.1; AT3G51370.1; AT3G51370 [Q9SD12-1]
AT3G51370.2; AT3G51370.2; AT3G51370 [Q9SD12-2]
AT3G51370.3; AT3G51370.3; AT3G51370 [Q9SD12-1]
KEGGiath:AT3G51370

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2C46_ARATH
AccessioniPrimary (citable) accession number: Q9SD12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health