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Q9SD12

- P2C46_ARATH

UniProt

Q9SD12 - P2C46_ARATH

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Protein

Probable protein phosphatase 2C 46

Gene

At3g51370

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Manganese 1By similarity
Metal bindingi84 – 841Manganese 2By similarity
Metal bindingi85 – 851Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi285 – 2851Manganese 2By similarity
Metal bindingi344 – 3441Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G51370-MONOMER.
ARA:GQT-49-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 46 (EC:3.1.3.16)
Short name:
AtPP2C46
Gene namesi
Ordered Locus Names:At3g51370
ORF Names:F26O13.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G51370.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 379359Probable protein phosphatase 2C 46PRO_0000367970Add
BLAST

Proteomic databases

PaxDbiQ9SD12.
PRIDEiQ9SD12.

Expressioni

Gene expression databases

GenevestigatoriQ9SD12.

Structurei

3D structure databases

ProteinModelPortaliQ9SD12.
SMRiQ9SD12. Positions 79-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 325247PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ9SD12.
OMAiVHELQPH.
PhylomeDBiQ9SD12.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9SD12-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSTLMKLLS ACLWPSSSSG KSSDSTGKQD GLLWYKDFGQ HLVGEFSMAV
60 70 80 90 100
VQANNLLEDQ SQVESGPLST LDSGPYGTFI GIYDGHGGPE TSRFVNDHLF
110 120 130 140 150
QHLKRFAAEQ ASMSVDVIKK AYEATEEGFL GVVTKQWPTK PQIAAVGSCC
160 170 180 190 200
LVGVICGGML YIANVGDSRA VLGRAMKATG EVIALQLSAE HNVSIESVRQ
210 220 230 240 250
EMHSLHPDDS HIVMLKHNVW RVKGLIQISR SIGDVYLKKA EFNKEPLYTK
260 270 280 290 300
YRIREPFKRP ILSGEPTITE HEIQPQDKFL IFASDGLWEQ MSNQEAVDIV
310 320 330 340 350
QNHPRNGIAR RLVKMALQEA AKKREMRYSD LKKIERGVRR HFHDDITVVI
360 370
IFLDTNQVSS VKGPPLSIRG GGMTFPKKI
Length:379
Mass (Da):42,179
Last modified:May 1, 2000 - v1
Checksum:i342934B0CA4CB760
GO
Isoform 2 (identifier: Q9SD12-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-105: HGGPETSRFVNDHLFQHLKR → MHTRLQTNRAETKILFEFSG

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:294
Mass (Da):33,107
Checksum:i418C3262DBAB0261
GO

Sequence cautioni

The sequence BX823319 differs from that shown. Reason: Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. CuratedVSP_036772Add
BLAST
Alternative sequencei86 – 10520HGGPE…QHLKR → MHTRLQTNRAETKILFEFSG in isoform 2. CuratedVSP_036773Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133452 Genomic DNA. Translation: CAB63001.1.
CP002686 Genomic DNA. Translation: AEE78784.1.
CP002686 Genomic DNA. Translation: AEE78785.1.
BX823319 mRNA. No translation available.
PIRiT45768.
RefSeqiNP_566949.2. NM_114996.3. [Q9SD12-1]
NP_974411.1. NM_202682.2. [Q9SD12-2]
UniGeneiAt.21696.

Genome annotation databases

EnsemblPlantsiAT3G51370.1; AT3G51370.1; AT3G51370. [Q9SD12-1]
GeneIDi824300.
KEGGiath:AT3G51370.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133452 Genomic DNA. Translation: CAB63001.1 .
CP002686 Genomic DNA. Translation: AEE78784.1 .
CP002686 Genomic DNA. Translation: AEE78785.1 .
BX823319 mRNA. No translation available.
PIRi T45768.
RefSeqi NP_566949.2. NM_114996.3. [Q9SD12-1 ]
NP_974411.1. NM_202682.2. [Q9SD12-2 ]
UniGenei At.21696.

3D structure databases

ProteinModelPortali Q9SD12.
SMRi Q9SD12. Positions 79-362.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9SD12.
PRIDEi Q9SD12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G51370.1 ; AT3G51370.1 ; AT3G51370 . [Q9SD12-1 ]
GeneIDi 824300.
KEGGi ath:AT3G51370.

Organism-specific databases

TAIRi AT3G51370.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000238703.
InParanoidi Q9SD12.
OMAi VHELQPH.
PhylomeDBi Q9SD12.

Enzyme and pathway databases

BioCyci ARA:AT3G51370-MONOMER.
ARA:GQT-49-MONOMER.

Gene expression databases

Genevestigatori Q9SD12.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C46_ARATH
AccessioniPrimary (citable) accession number: Q9SD12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3