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Q9SCX8

- PPA17_ARATH

UniProt

Q9SCX8 - PPA17_ARATH

Protein

Purple acid phosphatase 17

Gene

PAP17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Metallo-phosphoesterase involved in phosphate metabolism. Has a peroxidase activity.1 Publication

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.
    2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

    Cofactori

    Binds 1 iron ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Enzyme regulationi

    Inhibited by phosphate and molybdate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531IronBy similarity
    Metal bindingi86 – 861IronBy similarity
    Metal bindingi86 – 861ZincBy similarity
    Metal bindingi89 – 891IronBy similarity
    Metal bindingi124 – 1241ZincBy similarity
    Metal bindingi218 – 2181ZincBy similarity
    Active sitei227 – 2271Proton donorBy similarity
    Metal bindingi253 – 2531ZincBy similarity
    Metal bindingi255 – 2551IronBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW
    3. peroxidase activity Source: UniProtKB-EC
    4. phosphatase activity Source: TAIR

    GO - Biological processi

    1. cellular phosphate ion homeostasis Source: TAIR
    2. dephosphorylation Source: GOC
    3. response to hydrogen peroxide Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT3G17790-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purple acid phosphatase 17 (EC:3.1.3.2)
    Alternative name(s):
    Acid phosphatase type 5
    Peroxidase (EC:1.11.1.7)
    Gene namesi
    Name:PAP17
    Synonyms:ACP5
    Ordered Locus Names:At3g17790
    ORF Names:MEB5.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G17790.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cell surface Source: TAIR
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 338307Purple acid phosphatase 17PRO_5000065319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9SCX8.
    PRIDEiQ9SCX8.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, leaves, flowers and siliques.1 Publication

    Inductioni

    By phosphate starvation, during senescence, by ABA, by H2O2, and by salt stress.1 Publication

    Gene expression databases

    GenevestigatoriQ9SCX8.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SCX8.
    SMRiQ9SCX8. Positions 46-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 2553Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000239892.
    InParanoidiQ9SCX8.
    OMAiTNYELIY.
    PhylomeDBiQ9SCX8.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9SCX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSGRRSLMS ATASLSLLLC IFTTFVVVSN GELQRFIEPA KSDGSVSFIV    50
    IGDWGRRGSF NQSLVAYQMG KIGEKIDLDF VVSTGDNFYD NGLFSEHDPN 100
    FEQSFSNIYT APSLQKQWYS VLGNHDYRGD AEAQLSSVLR EIDSRWICLR 150
    SFVVDAELVE MFFVDTTPFV KEYYTEADGH SYDWRAVPSR NSYVKALLRD 200
    LEVSLKSSKA RWKIVVGHHA MRSIGHHGDT KELNEELLPI LKENGVDLYM 250
    NGHDHCLQHM SDEDSPIQFL TSGAGSKAWR GDINPVTINP KLLKFYYDGQ 300
    GFMSARFTHS DAEIVFYDVF GEILHKWVTS KQLLHSSV 338
    Length:338
    Mass (Da):38,297
    Last modified:May 1, 2000 - v1
    Checksum:i5183AE005E859740
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91M → I in AAM61192. 1 PublicationCurated
    Sequence conflicti115 – 1151Q → R in AAM61192. 1 PublicationCurated
    Sequence conflicti245 – 2451G → S in AAM61192. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133747 mRNA. Translation: CAC09923.1.
    AJ243527 Genomic DNA. Translation: CAB63938.1.
    AY818189 mRNA. Translation: AAV69751.1.
    AB019230 Genomic DNA. Translation: BAB02702.1.
    CP002686 Genomic DNA. Translation: AEE76007.1.
    BT003135 mRNA. Translation: AAO24567.1.
    AK228106 mRNA. Translation: BAF00065.1.
    AY084629 mRNA. Translation: AAM61192.1.
    RefSeqiNP_566587.1. NM_112660.5.
    UniGeneiAt.22111.
    At.71032.
    At.74878.
    At.74926.

    Genome annotation databases

    EnsemblPlantsiAT3G17790.1; AT3G17790.1; AT3G17790.
    GeneIDi821047.
    KEGGiath:AT3G17790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133747 mRNA. Translation: CAC09923.1 .
    AJ243527 Genomic DNA. Translation: CAB63938.1 .
    AY818189 mRNA. Translation: AAV69751.1 .
    AB019230 Genomic DNA. Translation: BAB02702.1 .
    CP002686 Genomic DNA. Translation: AEE76007.1 .
    BT003135 mRNA. Translation: AAO24567.1 .
    AK228106 mRNA. Translation: BAF00065.1 .
    AY084629 mRNA. Translation: AAM61192.1 .
    RefSeqi NP_566587.1. NM_112660.5.
    UniGenei At.22111.
    At.71032.
    At.74878.
    At.74926.

    3D structure databases

    ProteinModelPortali Q9SCX8.
    SMRi Q9SCX8. Positions 46-326.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9SCX8.
    PRIDEi Q9SCX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G17790.1 ; AT3G17790.1 ; AT3G17790 .
    GeneIDi 821047.
    KEGGi ath:AT3G17790.

    Organism-specific databases

    TAIRi AT3G17790.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000239892.
    InParanoidi Q9SCX8.
    OMAi TNYELIY.
    PhylomeDBi Q9SCX8.

    Enzyme and pathway databases

    BioCyci ARA:AT3G17790-MONOMER.

    Gene expression databases

    Genevestigatori Q9SCX8.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A type 5 acid phosphatase gene from Arabidopsis thaliana is induced by phosphate starvation and by some other types of phosphate mobilising/oxidative stress conditions."
      del Pozo J.C., Allona I., Rubio V., Leyva A., de la Pena A., Aragoncillo C., Paz-Ares J.
      Plant J. 19:579-589(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, ENZYME REGULATION, INDUCTION.
      Strain: cv. Landsberg erecta.
    2. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
      Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
      Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    3. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    7. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
      Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
      J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPPA17_ARATH
    AccessioniPrimary (citable) accession number: Q9SCX8
    Secondary accession number(s): Q8LFV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3