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Protein

Purple acid phosphatase 17

Gene

PAP17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallo-phosphoesterase involved in phosphate metabolism. Has a peroxidase activity.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.
2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Inhibited by phosphate and molybdate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53IronBy similarity1
Metal bindingi86IronBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi89IronBy similarity1
Metal bindingi124ZincBy similarity1
Metal bindingi218ZincBy similarity1
Active sitei227Proton donorBy similarity1
Metal bindingi253ZincBy similarity1
Metal bindingi255IronBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: UniProtKB-EC
  • phosphatase activity Source: TAIR

GO - Biological processi

  • cellular phosphate ion homeostasis Source: TAIR
  • response to hydrogen peroxide Source: TAIR

Keywordsi

Molecular functionHydrolase, Oxidoreductase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G17790-MONOMER
ReactomeiR-ATH-196843 Vitamin B2 (riboflavin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 17 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase type 5
Peroxidase (EC:1.11.1.7)
Gene namesi
Name:PAP17
Synonyms:ACP5
Ordered Locus Names:At3g17790
ORF Names:MEB5.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G17790
TAIRilocus:2088590 AT3G17790

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500006531932 – 338Purple acid phosphatase 17Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SCX8

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Inductioni

By phosphate starvation, during senescence, by ABA, by H2O2, and by salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ9SCX8 baseline and differential
GenevisibleiQ9SCX8 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT3G17790.1

Structurei

3D structure databases

ProteinModelPortaliQ9SCX8
SMRiQ9SCX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 255Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679 Eukaryota
COG1409 LUCA
HOGENOMiHOG000239892
InParanoidiQ9SCX8
KOiK14379
OMAiGNHDHFG
OrthoDBiEOG09360IST
PhylomeDBiQ9SCX8

Family and domain databases

CDDicd07378 MPP_ACP5, 1 hit
Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024927 Acid_Pase_5
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000898 Acid_Ptase_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SCX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGRRSLMS ATASLSLLLC IFTTFVVVSN GELQRFIEPA KSDGSVSFIV
60 70 80 90 100
IGDWGRRGSF NQSLVAYQMG KIGEKIDLDF VVSTGDNFYD NGLFSEHDPN
110 120 130 140 150
FEQSFSNIYT APSLQKQWYS VLGNHDYRGD AEAQLSSVLR EIDSRWICLR
160 170 180 190 200
SFVVDAELVE MFFVDTTPFV KEYYTEADGH SYDWRAVPSR NSYVKALLRD
210 220 230 240 250
LEVSLKSSKA RWKIVVGHHA MRSIGHHGDT KELNEELLPI LKENGVDLYM
260 270 280 290 300
NGHDHCLQHM SDEDSPIQFL TSGAGSKAWR GDINPVTINP KLLKFYYDGQ
310 320 330
GFMSARFTHS DAEIVFYDVF GEILHKWVTS KQLLHSSV
Length:338
Mass (Da):38,297
Last modified:May 1, 2000 - v1
Checksum:i5183AE005E859740
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9M → I in AAM61192 (Ref. 7) Curated1
Sequence conflicti115Q → R in AAM61192 (Ref. 7) Curated1
Sequence conflicti245G → S in AAM61192 (Ref. 7) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133747 mRNA Translation: CAC09923.1
AJ243527 Genomic DNA Translation: CAB63938.1
AY818189 mRNA Translation: AAV69751.1
AB019230 Genomic DNA Translation: BAB02702.1
CP002686 Genomic DNA Translation: AEE76007.1
BT003135 mRNA Translation: AAO24567.1
AK228106 mRNA Translation: BAF00065.1
AY084629 mRNA Translation: AAM61192.1
RefSeqiNP_566587.1, NM_112660.6
UniGeneiAt.22111
At.71032
At.74878
At.74926

Genome annotation databases

EnsemblPlantsiAT3G17790.1; AT3G17790.1; AT3G17790
GeneIDi821047
GrameneiAT3G17790.1; AT3G17790.1; AT3G17790
KEGGiath:AT3G17790

Similar proteinsi

Entry informationi

Entry nameiPPA17_ARATH
AccessioniPrimary (citable) accession number: Q9SCX8
Secondary accession number(s): Q8LFV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health