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Q9SCX8

- PPA17_ARATH

UniProt

Q9SCX8 - PPA17_ARATH

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Protein
Purple acid phosphatase 17
Gene
PAP17, ACP5, At3g17790, MEB5.10
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Metallo-phosphoesterase involved in phosphate metabolism. Has a peroxidase activity.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.
2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Binds 1 iron ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Enzyme regulationi

Inhibited by phosphate and molybdate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron By similarity
Metal bindingi86 – 861Iron By similarity
Metal bindingi86 – 861Zinc By similarity
Metal bindingi89 – 891Iron By similarity
Metal bindingi124 – 1241Zinc By similarity
Metal bindingi218 – 2181Zinc By similarity
Active sitei227 – 2271Proton donor By similarity
Metal bindingi253 – 2531Zinc By similarity
Metal bindingi255 – 2551Iron By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW
  3. peroxidase activity Source: UniProtKB-EC
  4. phosphatase activity Source: TAIR

GO - Biological processi

  1. cellular phosphate ion homeostasis Source: TAIR
  2. dephosphorylation Source: GOC
  3. response to hydrogen peroxide Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G17790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 17 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase type 5
Peroxidase (EC:1.11.1.7)
Gene namesi
Name:PAP17
Synonyms:ACP5
Ordered Locus Names:At3g17790
ORF Names:MEB5.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G17790.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cell surface Source: TAIR
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed prediction
Add
BLAST
Chaini32 – 338307Purple acid phosphatase 17
PRO_5000065319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SCX8.
PRIDEiQ9SCX8.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Inductioni

By phosphate starvation, during senescence, by ABA, by H2O2, and by salt stress.1 Publication

Gene expression databases

GenevestigatoriQ9SCX8.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9SCX8.
SMRiQ9SCX8. Positions 46-326.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 2553Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000239892.
InParanoidiQ9SCX8.
OMAiTNYELIY.
PhylomeDBiQ9SCX8.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SCX8-1 [UniParc]FASTAAdd to Basket

« Hide

MNSGRRSLMS ATASLSLLLC IFTTFVVVSN GELQRFIEPA KSDGSVSFIV    50
IGDWGRRGSF NQSLVAYQMG KIGEKIDLDF VVSTGDNFYD NGLFSEHDPN 100
FEQSFSNIYT APSLQKQWYS VLGNHDYRGD AEAQLSSVLR EIDSRWICLR 150
SFVVDAELVE MFFVDTTPFV KEYYTEADGH SYDWRAVPSR NSYVKALLRD 200
LEVSLKSSKA RWKIVVGHHA MRSIGHHGDT KELNEELLPI LKENGVDLYM 250
NGHDHCLQHM SDEDSPIQFL TSGAGSKAWR GDINPVTINP KLLKFYYDGQ 300
GFMSARFTHS DAEIVFYDVF GEILHKWVTS KQLLHSSV 338
Length:338
Mass (Da):38,297
Last modified:May 1, 2000 - v1
Checksum:i5183AE005E859740
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91M → I in AAM61192. 1 Publication
Sequence conflicti115 – 1151Q → R in AAM61192. 1 Publication
Sequence conflicti245 – 2451G → S in AAM61192. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133747 mRNA. Translation: CAC09923.1.
AJ243527 Genomic DNA. Translation: CAB63938.1.
AY818189 mRNA. Translation: AAV69751.1.
AB019230 Genomic DNA. Translation: BAB02702.1.
CP002686 Genomic DNA. Translation: AEE76007.1.
BT003135 mRNA. Translation: AAO24567.1.
AK228106 mRNA. Translation: BAF00065.1.
AY084629 mRNA. Translation: AAM61192.1.
RefSeqiNP_566587.1. NM_112660.5.
UniGeneiAt.22111.
At.71032.
At.74878.
At.74926.

Genome annotation databases

EnsemblPlantsiAT3G17790.1; AT3G17790.1; AT3G17790.
GeneIDi821047.
KEGGiath:AT3G17790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133747 mRNA. Translation: CAC09923.1 .
AJ243527 Genomic DNA. Translation: CAB63938.1 .
AY818189 mRNA. Translation: AAV69751.1 .
AB019230 Genomic DNA. Translation: BAB02702.1 .
CP002686 Genomic DNA. Translation: AEE76007.1 .
BT003135 mRNA. Translation: AAO24567.1 .
AK228106 mRNA. Translation: BAF00065.1 .
AY084629 mRNA. Translation: AAM61192.1 .
RefSeqi NP_566587.1. NM_112660.5.
UniGenei At.22111.
At.71032.
At.74878.
At.74926.

3D structure databases

ProteinModelPortali Q9SCX8.
SMRi Q9SCX8. Positions 46-326.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9SCX8.
PRIDEi Q9SCX8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G17790.1 ; AT3G17790.1 ; AT3G17790 .
GeneIDi 821047.
KEGGi ath:AT3G17790.

Organism-specific databases

TAIRi AT3G17790.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000239892.
InParanoidi Q9SCX8.
OMAi TNYELIY.
PhylomeDBi Q9SCX8.

Enzyme and pathway databases

BioCyci ARA:AT3G17790-MONOMER.

Gene expression databases

Genevestigatori Q9SCX8.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A type 5 acid phosphatase gene from Arabidopsis thaliana is induced by phosphate starvation and by some other types of phosphate mobilising/oxidative stress conditions."
    del Pozo J.C., Allona I., Rubio V., Leyva A., de la Pena A., Aragoncillo C., Paz-Ares J.
    Plant J. 19:579-589(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, ENZYME REGULATION, INDUCTION.
    Strain: cv. Landsberg erecta.
  2. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
    Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
    Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  3. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
    Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
    J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPPA17_ARATH
AccessioniPrimary (citable) accession number: Q9SCX8
Secondary accession number(s): Q8LFV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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