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Protein

Cell division control protein 48 homolog D

Gene

CDC48D

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi249 – 2568ATPSequence analysis
Nucleotide bindingi522 – 5298ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of protein catabolic process Source: TAIR
  • protein transport Source: UniProtKB-KW
  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-110320. Translesion Synthesis by POLH.
R-ATH-3371511. HSF1 activation.
R-ATH-5358346. Hedgehog ligand biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 48 homolog D
Short name:
AtCDC48d
Alternative name(s):
Transitional endoplasmic reticulum ATPase D
Gene namesi
Name:CDC48D
Ordered Locus Names:At3g53230
ORF Names:T4D2.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G53230.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-KW
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • nucleolus Source: TAIR
  • nucleoplasm Source: TAIR
  • phragmoplast Source: UniProtKB-SubCell
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 815814Cell division control protein 48 homolog DPRO_0000084582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei720 – 7201PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9SCN8.
PRIDEiQ9SCN8.

PTM databases

iPTMnetiQ9SCN8.

Expressioni

Gene expression databases

GenevisibleiQ9SCN8. AT.

Interactioni

Protein-protein interaction databases

BioGridi9806. 3 interactions.
STRINGi3702.AT3G53230.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SCN8.
SMRiQ9SCN8. Positions 22-766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000223224.
InParanoidiQ9SCN8.
KOiK13525.
OMAiQTIPFKV.
OrthoDBiEOG093602AN.
PhylomeDBiQ9SCN8.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SCN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQAESSDS KGTKKDFSTA ILEKKKAANR LVVDEAINDD NSVVSLHPDT
60 70 80 90 100
MEKLQLFRGD TILIKGKKRK DTVCIALADE TCDEPKIRMN KVVRSNLRVR
110 120 130 140 150
LGDVISVHQC PDVKYGNRVH ILPLDDTIEG VSGNIFDAYL KPYFLEAYRP
160 170 180 190 200
VRKGDLFLVR GGMRSIEFKV IETDPAEYCV VAPDTEIFCE GEPIKREDEE
210 220 230 240 250
RLDEVGYDDV GGVRKQMAQI RELVELPLRH PQLFKSIGVK PPKGILLYGP
260 270 280 290 300
PGSGKTLIAR AVANETGAFF FCINGPEIMS KLAGESESNL RKAFEEAEKN
310 320 330 340 350
APSIIFIDEI DSIAPKREKT HGEVERRIVS QLLTLMDGLK SRAHVIVMGA
360 370 380 390 400
TNRPNSIDPA LRRFGRFDRE IDIGVPDEIG RLEVLRIHTK NMKLAEDVDL
410 420 430 440 450
ERVSKDTHGY VGADLAALCT EAALQCIREK MDVIDLDDEE IDAEILNSMA
460 470 480 490 500
VSNDHFQTAL GNSNPSALRE TVVEVPNVSW EDIGGLENVK RELQETVQYP
510 520 530 540 550
VEHPEKFEKF GMSPSKGVLF YGPPGCGKTL LAKAIANECQ ANFISIKGPE
560 570 580 590 600
LLTMWFGESE ANVREIFDKA RQSAPCVLFF DELDSIATQR GNSVGDAGGA
610 620 630 640 650
ADRVLNQLLT EMDGMNAKKT VFIIGATNRP DIIDPALLRP GRLDQLIYIP
660 670 680 690 700
LPDEESRYQI FKSCLRKSPV AKDVDLRALA KYTQGFSGAD ITEICQRSCK
710 720 730 740 750
YAIRENIEKD IEKERKRAES PEAMEEDEEE IAEIKAGHFE ESMKYARRSV
760 770 780 790 800
SDADIRKYQA FAQTLQQSRG FGSEFRFPDA PTGTTGAFPG AAATVGGVDP
810
FATSGGAADD DDLYS
Length:815
Mass (Da):90,340
Last modified:May 1, 2000 - v1
Checksum:i8F2817396748B6CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132958 Genomic DNA. Translation: CAB64226.1.
CP002686 Genomic DNA. Translation: AEE79050.1.
AK228801 mRNA. Translation: BAF00697.1.
PIRiT46169.
RefSeqiNP_190891.1. NM_115183.3.
UniGeneiAt.23168.

Genome annotation databases

EnsemblPlantsiAT3G53230.1; AT3G53230.1; AT3G53230.
GeneIDi824489.
GrameneiAT3G53230.1; AT3G53230.1; AT3G53230.
KEGGiath:AT3G53230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132958 Genomic DNA. Translation: CAB64226.1.
CP002686 Genomic DNA. Translation: AEE79050.1.
AK228801 mRNA. Translation: BAF00697.1.
PIRiT46169.
RefSeqiNP_190891.1. NM_115183.3.
UniGeneiAt.23168.

3D structure databases

ProteinModelPortaliQ9SCN8.
SMRiQ9SCN8. Positions 22-766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9806. 3 interactions.
STRINGi3702.AT3G53230.1.

PTM databases

iPTMnetiQ9SCN8.

Proteomic databases

PaxDbiQ9SCN8.
PRIDEiQ9SCN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G53230.1; AT3G53230.1; AT3G53230.
GeneIDi824489.
GrameneiAT3G53230.1; AT3G53230.1; AT3G53230.
KEGGiath:AT3G53230.

Organism-specific databases

TAIRiAT3G53230.

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000223224.
InParanoidiQ9SCN8.
KOiK13525.
OMAiQTIPFKV.
OrthoDBiEOG093602AN.
PhylomeDBiQ9SCN8.

Enzyme and pathway databases

ReactomeiR-ATH-110320. Translesion Synthesis by POLH.
R-ATH-3371511. HSF1 activation.
R-ATH-5358346. Hedgehog ligand biogenesis.

Miscellaneous databases

PROiQ9SCN8.

Gene expression databases

GenevisibleiQ9SCN8. AT.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD48D_ARATH
AccessioniPrimary (citable) accession number: Q9SCN8
Secondary accession number(s): Q0WQA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.