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Q9SCJ9

- UBP26_ARATH

UniProt

Q9SCJ9 - UBP26_ARATH

Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (03 May 2011)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151Nucleophile
    Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. seed development Source: TAIR
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT3G49600-MONOMER.

    Protein family/group databases

    MEROPSiC19.A35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 26
    Short name:
    AtUBP26
    Ubiquitin thioesterase 26
    Ubiquitin-specific-processing protease 26
    Gene namesi
    Name:UBP26
    Synonyms:SUP32
    Ordered Locus Names:At3g49600
    ORF Names:T9C5.190
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G49600.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi115 – 1151C → S: Loss of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10671067Ubiquitin carboxyl-terminal hydrolase 26PRO_0000293492Add
    BLAST

    Proteomic databases

    PaxDbiQ9SCJ9.
    PRIDEiQ9SCJ9.

    Expressioni

    Tissue specificityi

    Expressed in seedlings, roots, stems, leaves and inflorescences.1 Publication

    Gene expression databases

    GenevestigatoriQ9SCJ9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SCJ9.
    SMRiQ9SCJ9. Positions 107-390, 966-1019.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 442337USPAdd
    BLAST
    Domaini503 – 59593DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini610 – 711102DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini738 – 861124DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini948 – 103184Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi392 – 43241Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000090485.
    InParanoidiQ9SCJ9.
    KOiK11858.
    OMAiLADMNIF.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9SCJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPNTRNKN KRQRPDAVDS SSQILRKIHE ANDVTDDDIN QLFMIWKPVC     50
    QGCRVNTRDN PNCFCGLVPP LNGSRKSGLW QKTSEIIQSL GPDPTLDRRD 100
    SESTPAGLTN LGATCYANSI LQCLYMNTAF REGVFSVEVH VLKQNPVLDQ 150
    IARLFAQLHA SQKSFVDSDA FVKTLELDNG VQQDTHEFLT LLLSLLERCL 200
    LHSGVKAKTI VQDLFSGSVS HVTTCSKCGR DSEASSKMED FYALELNVKG 250
    LKSLDASLND YLSLEQLNGD NQYFCGSCNA RVDATRCIKL RTLPPVITFQ 300
    LKRCIFLPKT TAKKKITSSF SFPQVLDMGS RLAESSQNKL TYDLSAVLIH 350
    KGSAVNSGHY VAHIKDEKTG LWWEFDDEHV SELGKRPCNE ASSSTPQSES 400
    NGTASSGNIT DGIQSGSSDC RSAIKSEVFS SSDAYMLMYS LRCDKQENQE 450
    GQKENPIDIT KGEVKQLKGG YLPKHLSEWI NNMNAVFLES CKQYNLRKEK 500
    ELNALTERRQ EVRTILSEAA VQSLEEQYFW ISTDWLRLWA DTTLPPALDN 550
    TPLLCSHGKV HASKVNCMKR ISELAWIKLE SKFNGGPKLG KGDYCRDCLM 600
    DGARMVVSSD SYRDRRTFMK SIANDVLSGK CEDGMYYISR AWLQQWIKRK 650
    NLDAPTEADA GPTNAITCNH GELMPEQAPG AKRVVVPENF WSFLFEDALK 700
    VMSEDTLDCT CFPVDSSQCC HCTEVLSEVA CFEDSLRTLK VKQRQNHEKL 750
    ATGKGIPLTP QSRYFLLPSP WLVQWRIYIN MTGKNSSSAP EPERLDGVIN 800
    TLKCKKHTRL LERLPELVCR RGSYFQKNPS TDKLTIIPEL DWKYFCDEWG 850
    GLMENGISAF IEVGNTDQSS SPDVIDLEKD SSPDDNMDVD AQQLILRASP 900
    EICEECIGER ESCELMQKLS YSEGDVFVCF VRGKEAPKAM LEASDSSFEV 950
    DRRTSKRSRR TNYGNLTSLK VSATTTVYQL KMMIWELLGV MKENQELHKG 1000
    SKVIDQESAT LADMNIFPGD RLWVRDTEMH EHRDIADELC EKKPGAQDIE 1050
    EGFRGTLLTG NISSEAC 1067
    Length:1,067
    Mass (Da):119,934
    Last modified:May 3, 2011 - v3
    Checksum:iC0338D496C035573
    GO

    Sequence cautioni

    The sequence CAB62464.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti935 – 9351E → G in AAG42764. (PubMed:11115897)Curated
    Sequence conflicti989 – 9891G → E in AAG42764. (PubMed:11115897)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302674 mRNA. Translation: AAG42764.1.
    AL132964 Genomic DNA. Translation: CAB62464.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE78564.1.
    PIRiT46237.
    RefSeqiNP_566922.1. NM_114820.3.
    UniGeneiAt.22294.

    Genome annotation databases

    EnsemblPlantsiAT3G49600.1; AT3G49600.1; AT3G49600.
    GeneIDi824122.
    KEGGiath:AT3G49600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF302674 mRNA. Translation: AAG42764.1 .
    AL132964 Genomic DNA. Translation: CAB62464.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE78564.1 .
    PIRi T46237.
    RefSeqi NP_566922.1. NM_114820.3.
    UniGenei At.22294.

    3D structure databases

    ProteinModelPortali Q9SCJ9.
    SMRi Q9SCJ9. Positions 107-390, 966-1019.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A35.

    Proteomic databases

    PaxDbi Q9SCJ9.
    PRIDEi Q9SCJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G49600.1 ; AT3G49600.1 ; AT3G49600 .
    GeneIDi 824122.
    KEGGi ath:AT3G49600.

    Organism-specific databases

    TAIRi AT3G49600.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000090485.
    InParanoidi Q9SCJ9.
    KOi K11858.
    OMAi LADMNIF.

    Enzyme and pathway databases

    BioCyci ARA:AT3G49600-MONOMER.

    Gene expression databases

    Genevestigatori Q9SCJ9.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY ORGANIZATION, NOMENCLATURE.
    2. "Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination."
      Sridhar V.V., Kapoor A., Zhang K., Zhu J., Zhou T., Hasegawa P.M., Bressan R.A., Zhu J.-K.
      Nature 447:735-738(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-115, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiUBP26_ARATH
    AccessioniPrimary (citable) accession number: Q9SCJ9
    Secondary accession number(s): Q9FPS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3