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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115Nucleophile1
Active sitei359Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • protein deubiquitination Source: InterPro
  • seed development Source: TAIR
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.068

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Short name:
AtUBP26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:UBP26
Synonyms:SUP32
Ordered Locus Names:At3g49600
ORF Names:T9C5.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G49600
TAIRilocus:2114653 AT3G49600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi115C → S: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002934921 – 1067Ubiquitin carboxyl-terminal hydrolase 26Add BLAST1067

Proteomic databases

PaxDbiQ9SCJ9
PRIDEiQ9SCJ9

PTM databases

iPTMnetiQ9SCJ9

Expressioni

Tissue specificityi

Expressed in seedlings, roots, stems, leaves and inflorescences.1 Publication

Gene expression databases

ExpressionAtlasiQ9SCJ9 baseline and differential
GenevisibleiQ9SCJ9 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G49600.1

Structurei

3D structure databases

ProteinModelPortaliQ9SCJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 442USPAdd BLAST337
Domaini503 – 595DUSP 1PROSITE-ProRule annotationAdd BLAST93
Domaini610 – 711DUSP 2PROSITE-ProRule annotationAdd BLAST102
Domaini738 – 861DUSP 3PROSITE-ProRule annotationAdd BLAST124
Domaini948 – 1031Ubiquitin-likePROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi392 – 432Ser-richAdd BLAST41

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1863 Eukaryota
COG5077 LUCA
HOGENOMiHOG000090485
InParanoidiQ9SCJ9
KOiK11858
OMAiHPGQKYY
OrthoDBiEOG093600UV

Family and domain databases

CDDicd02668 Peptidase_C19L, 1 hit
InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR033841 USP48
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 3 hits
PS50053 UBIQUITIN_2, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SCJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPNTRNKN KRQRPDAVDS SSQILRKIHE ANDVTDDDIN QLFMIWKPVC
60 70 80 90 100
QGCRVNTRDN PNCFCGLVPP LNGSRKSGLW QKTSEIIQSL GPDPTLDRRD
110 120 130 140 150
SESTPAGLTN LGATCYANSI LQCLYMNTAF REGVFSVEVH VLKQNPVLDQ
160 170 180 190 200
IARLFAQLHA SQKSFVDSDA FVKTLELDNG VQQDTHEFLT LLLSLLERCL
210 220 230 240 250
LHSGVKAKTI VQDLFSGSVS HVTTCSKCGR DSEASSKMED FYALELNVKG
260 270 280 290 300
LKSLDASLND YLSLEQLNGD NQYFCGSCNA RVDATRCIKL RTLPPVITFQ
310 320 330 340 350
LKRCIFLPKT TAKKKITSSF SFPQVLDMGS RLAESSQNKL TYDLSAVLIH
360 370 380 390 400
KGSAVNSGHY VAHIKDEKTG LWWEFDDEHV SELGKRPCNE ASSSTPQSES
410 420 430 440 450
NGTASSGNIT DGIQSGSSDC RSAIKSEVFS SSDAYMLMYS LRCDKQENQE
460 470 480 490 500
GQKENPIDIT KGEVKQLKGG YLPKHLSEWI NNMNAVFLES CKQYNLRKEK
510 520 530 540 550
ELNALTERRQ EVRTILSEAA VQSLEEQYFW ISTDWLRLWA DTTLPPALDN
560 570 580 590 600
TPLLCSHGKV HASKVNCMKR ISELAWIKLE SKFNGGPKLG KGDYCRDCLM
610 620 630 640 650
DGARMVVSSD SYRDRRTFMK SIANDVLSGK CEDGMYYISR AWLQQWIKRK
660 670 680 690 700
NLDAPTEADA GPTNAITCNH GELMPEQAPG AKRVVVPENF WSFLFEDALK
710 720 730 740 750
VMSEDTLDCT CFPVDSSQCC HCTEVLSEVA CFEDSLRTLK VKQRQNHEKL
760 770 780 790 800
ATGKGIPLTP QSRYFLLPSP WLVQWRIYIN MTGKNSSSAP EPERLDGVIN
810 820 830 840 850
TLKCKKHTRL LERLPELVCR RGSYFQKNPS TDKLTIIPEL DWKYFCDEWG
860 870 880 890 900
GLMENGISAF IEVGNTDQSS SPDVIDLEKD SSPDDNMDVD AQQLILRASP
910 920 930 940 950
EICEECIGER ESCELMQKLS YSEGDVFVCF VRGKEAPKAM LEASDSSFEV
960 970 980 990 1000
DRRTSKRSRR TNYGNLTSLK VSATTTVYQL KMMIWELLGV MKENQELHKG
1010 1020 1030 1040 1050
SKVIDQESAT LADMNIFPGD RLWVRDTEMH EHRDIADELC EKKPGAQDIE
1060
EGFRGTLLTG NISSEAC
Length:1,067
Mass (Da):119,934
Last modified:May 3, 2011 - v3
Checksum:iC0338D496C035573
GO

Sequence cautioni

The sequence CAB62464 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti935E → G in AAG42764 (PubMed:11115897).Curated1
Sequence conflicti989G → E in AAG42764 (PubMed:11115897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302674 mRNA Translation: AAG42764.1
AL132964 Genomic DNA Translation: CAB62464.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE78564.1
CP002686 Genomic DNA Translation: ANM63555.1
PIRiT46237
RefSeqiNP_001325635.1, NM_001339429.1
NP_566922.1, NM_114820.4
UniGeneiAt.22294

Genome annotation databases

EnsemblPlantsiAT3G49600.1; AT3G49600.1; AT3G49600
AT3G49600.2; AT3G49600.2; AT3G49600
GeneIDi824122
GrameneiAT3G49600.1; AT3G49600.1; AT3G49600
AT3G49600.2; AT3G49600.2; AT3G49600
KEGGiath:AT3G49600

Similar proteinsi

Entry informationi

Entry nameiUBP26_ARATH
AccessioniPrimary (citable) accession number: Q9SCJ9
Secondary accession number(s): Q9FPS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health