Q9SCG9 (MPAC1_CUPAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major pollen allergen Cup a 1 Alternative name(s): Allergen=Cup a 1
Organism	Cupressus arizonica (Arizona cypress)
Taxonomic identifier	49011 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Coniferophyta › Coniferopsida › Coniferales › Cupressaceae › Hesperocyparis

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the polysaccharide lyase 1 family. Amb a subfamily.

Ontologies

Keywords
Disease	Allergen
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Major pollen allergen Cup a 1		PRO_0000212997
Amino acid modifications
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Disulfide bond	7 ↔ 24		By similarity
	Disulfide bond	107 ↔ 126		By similarity
	Disulfide bond	285 ↔ 291		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9SCG9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F1281DCDA1D5DFD0	FASTA	346	37,589
	10 20 30 40 50 60 DNPIDSCWRG DSNWDQNRMK LADCVVGFGS STMGGKGGEI YTVTSSEDNP VNPTPGTLRY 70 80 90 100 110 120 GATREKALWI IFSQNMNIKL QMPLYVAGYK TIDGRGAVVH LGNGGPCLFM RKASHVILHG 130 140 150 160 170 180 LHIHGCNTSV LGDVLVSESI GVEPVHAQDG DAITMRNVTN AWIDHNSLSD CSDGLIDVTL 190 200 210 220 230 240 GSTGITISNN HFFNHHKVML LGHDDTYDDD KSMKVTVAFN QFGPNAGQRM PRARYGLVHV 250 260 270 280 290 300 ANNNYDQWNI YAIGGSSNPT ILSEGNSFTA PNESYKKEVT KRIGCETTSA CANWVWRSTR 310 320 330 340 DAFTNGAYFV SSGKAEDTNI YNSNEAFKVE NGNAAPQLTQ NAGVVA

References

[1]

"Molecular cloning of major allergen from Cupressus arizonica pollen: Cup a 1." Aceituno E., Del Pozo V., Minguez A., Arrieta I., Cortegano I., Cardaba B., Gallardo S., Rojo M., Palomino P., Lahoz C. Clin. Exp. Allergy 30:1750-1758(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243570 mRNA. Translation: CAB62551.1.
3D structure databases
ProteinModelPortal	Q9SCG9.
SMR	Q9SCG9. Positions 1-345.
ModBase	Search...
Protein family/group databases
Allergome	256. Cup a 1. 3232. Cup a 1.0101.
CAZy	PL1. Polysaccharide Lyase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.160.20.10. 1 hit.
InterPro	IPR002022. Amb_allergen_dom. IPR018082. AmbAllergen. IPR012334. Pectin_lyas_fold. IPR011050. Pectin_lyase_fold/virulence. [Graphical view]
Pfam	PF00544. Pec_lyase_C. 1 hit. [Graphical view]
PRINTS	PR00807. AMBALLERGEN.
SMART	SM00656. Amb_all. 1 hit. [Graphical view]
SUPFAM	SSF51126. Pectin_lyas_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPAC1_CUPAR

Accession

Primary (citable) accession number: Q9SCG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program