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Q9SBL5

- CHS4_SORBI

UniProt

Q9SBL5 - CHS4_SORBI

Protein

Chalcone synthase 4

Gene

CHS4

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 4 (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase 4
    Gene namesi
    Name:CHS4
    OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
    Taxonomic identifieri4558 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

    Organism-specific databases

    GrameneiQ9SBL5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Chalcone synthase 4PRO_0000216058Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4558.Sb05g020160.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SBL5.
    SMRiQ9SBL5. Positions 7-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Phylogenomic databases

    HOGENOMiHOG000245460.
    KOiK00660.
    OMAiQVEKPLF.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9SBL5-1 [UniParc]FASTAAdd to Basket

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    MAAATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS    50
    EHMTELKEKF KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD 100
    IVVVEVPKLG KAAAQKAIKE WGQPKSKITH LVFCTTSGVD MPGADYQLTK 150
    MLGLRPSVKR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV 200
    TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL FQLVSASQTI 250
    LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERSLEEA FKPLGITDYN 300
    SIFWVAHPGG PAILDQVEAK VGLKKERMRA TRHVLSEYGN MSSACVLFIL 350
    DEMRKRSAED GQATTGEGLD WGVLFGFGPG LTVETVVLHS VPITTGAAIT 400
    A 401
    Length:401
    Mass (Da):43,669
    Last modified:May 1, 2000 - v1
    Checksum:i55D52AF3717326C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152551 Genomic DNA. Translation: AAD41876.1.
    RefSeqiXP_002450870.1. XM_002450825.1.
    UniGeneiSbi.4197.

    Genome annotation databases

    GeneIDi8056976.
    KEGGisbi:SORBI_05g020160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152551 Genomic DNA. Translation: AAD41876.1 .
    RefSeqi XP_002450870.1. XM_002450825.1.
    UniGenei Sbi.4197.

    3D structure databases

    ProteinModelPortali Q9SBL5.
    SMRi Q9SBL5. Positions 7-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4558.Sb05g020160.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8056976.
    KEGGi sbi:SORBI_05g020160.

    Organism-specific databases

    Gramenei Q9SBL5.

    Phylogenomic databases

    HOGENOMi HOG000245460.
    KOi K00660.
    OMAi QVEKPLF.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of chalcone synthase genes from sorghum."
      Lo S.-C.C., Nicholson R.L.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. BTx623.

    Entry informationi

    Entry nameiCHS4_SORBI
    AccessioniPrimary (citable) accession number: Q9SBL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3