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Q9SBL4

- CHS5_SORBI

UniProt

Q9SBL4 - CHS5_SORBI

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Protein

Chalcone synthase 5

Gene

CHS5

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 5 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 5
Gene namesi
Name:CHS5
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

Organism-specific databases

GrameneiQ9SBL4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Chalcone synthase 5PRO_0000216059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb05g020150.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SBL4.
SMRiQ9SBL4. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

HOGENOMiHOG000245460.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SBL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS
60 70 80 90 100
EHMTELKEKF KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD
110 120 130 140 150
IVVVEVPKLG KAAAHKAIKE WGQPKSKITH LVFCTTSGVD MPGADYQLTK
160 170 180 190 200
MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV
210 220 230 240 250
TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL FQLVSASQTI
260 270 280 290 300
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERSLEEA FKPLGITDYN
310 320 330 340 350
SIFWVAHPGG PAILDQVEAK VGLEKERMRA TRHVLSEYGN MSSACVLFIL
360 370 380 390 400
DEMRKRSAED GQATTGEGFD WGVLFGFGPG LTVETVVLHS VPITTGAAIT

A
Length:401
Mass (Da):43,699
Last modified:May 1, 2000 - v1
Checksum:i0329939544154397
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152552 Genomic DNA. Translation: AAD41877.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152552 Genomic DNA. Translation: AAD41877.1 .

3D structure databases

ProteinModelPortali Q9SBL4.
SMRi Q9SBL4. Positions 7-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4558.Sb05g020150.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q9SBL4.

Phylogenomic databases

HOGENOMi HOG000245460.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of chalcone synthase genes from sorghum."
    Lo S.-C.C., Nicholson R.L.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. BTx623.

Entry informationi

Entry nameiCHS5_SORBI
AccessioniPrimary (citable) accession number: Q9SBL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3