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Q9SBL3 (CHS6_SORBI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 6

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 6
Gene names
Name:CHS6
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifier4558 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 401401Chalcone synthase 6
PRO_0000216060

Sites

Active site1681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9SBL3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EEBE8C8510FFC700

FASTA40143,705
        10         20         30         40         50         60 
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS EHMTELKEKF 

        70         80         90        100        110        120 
KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD IVVVEVPKLG KAAAQKAIKE 

       130        140        150        160        170        180 
WGQPKSKITH LVFCTTSGVD MPGADYQLTK MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD 

       190        200        210        220        230        240 
LAENNRGARV LVVCSEITAV TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL 

       250        260        270        280        290        300 
FQLVSASQTI LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERSLEEA FKPLGITDYN 

       310        320        330        340        350        360 
SIFWVAHPGG PAILDQVEAK VGLKKERMRA TRHVLSEYGN MSSACVLFIL DEMRKRSAED 

       370        380        390        400 
GQATTGEGFD WGVLFGFGPG LTVETVVLHS VPITTGATIT A 

« Hide

References

[1]"Molecular cloning of chalcone synthase genes from sorghum."
Lo S.-C.C., Nicholson R.L.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. BTx623.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152553 Genomic DNA. Translation: AAD41878.1.
RefSeqXP_002450877.1. XM_002450832.1.
UniGeneSbi.20207.

3D structure databases

ProteinModelPortalQ9SBL3.
SMRQ9SBL3. Positions 7-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4558.Sb05g020230.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8064820.
KEGGsbi:SORBI_05g020230.

Organism-specific databases

GrameneQ9SBL3.

Phylogenomic databases

HOGENOMHOG000245460.
KOK00660.
OMAHAHAGVE.
ProtClustDBPLN03170.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS6_SORBI
AccessionPrimary (citable) accession number: Q9SBL3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways