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Protein

Zinc-finger homeodomain protein 2

Gene

ZHD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential protein. Putative transcription factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei209Required for DNA-bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 98ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50
DNA bindingi157 – 220Homeobox; atypicalAdd BLAST64

GO - Molecular functioni

  • DNA binding Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-finger homeodomain protein 2
Short name:
AtZHD2
Alternative name(s):
Homeobox protein 22
Short name:
AtHB-22
Protein MATERNAL EFFECT EMBRYO ARREST 68
Gene namesi
Name:ZHD1
Synonyms:HB22, MEE68
Ordered Locus Names:At4g24660
ORF Names:F22K18.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G24660.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Arrested at early embryo stages.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568461 – 220Zinc-finger homeodomain protein 2Add BLAST220

Proteomic databases

PaxDbiQ9SB61.

Expressioni

Tissue specificityi

Mostly expressed in flowers and, to a lower extent, in inflorescence, stems and leaves.1 Publication

Gene expression databases

GenevisibleiQ9SB61. AT.

Interactioni

Subunit structurei

Homo or heterodimer. Interacts with ZHD1, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZHD8Q9LXG03EBI-1806256,EBI-1806405

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi13857. 2 interactors.
IntActiQ9SB61. 10 interactors.
STRINGi3702.AT4G24660.1.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi166 – 179Combined sources14
Helixi189 – 197Combined sources9
Helixi202 – 210Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH7NMR-A148-214[»]
ProteinModelPortaliQ9SB61.
SMRiQ9SB61.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SB61.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 38Poly-Gly6

Domaini

The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.Curated
Contains 1 ZF-HD dimerization-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 98ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Homeobox, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX1N. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
InParanoidiQ9SB61.
OMAiNHAVNIG.
OrthoDBiEOG09360PCW.
PhylomeDBiQ9SB61.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SB61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEDQEEDM EMSGVNPPCG YDSLSGEGAT SSGGGGVGRS KGVGAKIRYR
60 70 80 90 100
ECLKNHAVNI GGHAVDGCCE FMPSGEDGTL DALKCAACGC HRNFHRKETE
110 120 130 140 150
SIGGRAHRVP TYYNRPPQPH QPPGYLHLTS PAAPYRPPAA SGDEEDTSNP
160 170 180 190 200
SSSGGTTKRF RTKFTAEQKE KMLAFAERLG WRIQKHDDVA VEQFCAETGV
210 220
RRQVLKIWMH NNKNSLGKKP
Length:220
Mass (Da):24,023
Last modified:May 1, 2000 - v1
Checksum:i9E8F5BF68AA06897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035356 Genomic DNA. Translation: CAA22997.1.
AL161561 Genomic DNA. Translation: CAB79376.1.
CP002687 Genomic DNA. Translation: AEE84939.1.
AF439841 mRNA. Translation: AAL27510.1.
AY125563 mRNA. Translation: AAM78073.1.
PIRiT05568.
RefSeqiNP_194197.1. NM_118599.2.
UniGeneiAt.2543.

Genome annotation databases

EnsemblPlantsiAT4G24660.1; AT4G24660.1; AT4G24660.
GeneIDi828568.
GrameneiAT4G24660.1; AT4G24660.1; AT4G24660.
KEGGiath:AT4G24660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035356 Genomic DNA. Translation: CAA22997.1.
AL161561 Genomic DNA. Translation: CAB79376.1.
CP002687 Genomic DNA. Translation: AEE84939.1.
AF439841 mRNA. Translation: AAL27510.1.
AY125563 mRNA. Translation: AAM78073.1.
PIRiT05568.
RefSeqiNP_194197.1. NM_118599.2.
UniGeneiAt.2543.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH7NMR-A148-214[»]
ProteinModelPortaliQ9SB61.
SMRiQ9SB61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13857. 2 interactors.
IntActiQ9SB61. 10 interactors.
STRINGi3702.AT4G24660.1.

Proteomic databases

PaxDbiQ9SB61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G24660.1; AT4G24660.1; AT4G24660.
GeneIDi828568.
GrameneiAT4G24660.1; AT4G24660.1; AT4G24660.
KEGGiath:AT4G24660.

Organism-specific databases

TAIRiAT4G24660.

Phylogenomic databases

eggNOGiENOG410IX1N. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
InParanoidiQ9SB61.
OMAiNHAVNIG.
OrthoDBiEOG09360PCW.
PhylomeDBiQ9SB61.

Miscellaneous databases

EvolutionaryTraceiQ9SB61.
PROiQ9SB61.

Gene expression databases

GenevisibleiQ9SB61. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZHD2_ARATH
AccessioniPrimary (citable) accession number: Q9SB61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.