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Protein

Zinc-finger homeodomain protein 2

Gene

ZHD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential protein. Putative transcription factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei209Required for DNA-bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 98ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50
DNA bindingi157 – 220Homeobox; atypicalAdd BLAST64

GO - Molecular functioni

  • DNA binding Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-finger homeodomain protein 2
Short name:
AtZHD2
Alternative name(s):
Homeobox protein 22
Short name:
AtHB-22
Protein MATERNAL EFFECT EMBRYO ARREST 68
Gene namesi
Name:ZHD1
Synonyms:HB22, MEE68
Ordered Locus Names:At4g24660
ORF Names:F22K18.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G24660
TAIRilocus:2121989 AT4G24660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Arrested at early embryo stages.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568461 – 220Zinc-finger homeodomain protein 2Add BLAST220

Proteomic databases

PaxDbiQ9SB61

Expressioni

Tissue specificityi

Mostly expressed in flowers and, to a lower extent, in inflorescence, stems and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ9SB61 baseline and differential
GenevisibleiQ9SB61 AT

Interactioni

Subunit structurei

Homo or heterodimer. Interacts with ZHD1, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZHD8Q9LXG03EBI-1806256,EBI-1806405

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi13857, 2 interactors
IntActiQ9SB61, 10 interactors
STRINGi3702.AT4G24660.1

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi166 – 179Combined sources14
Helixi189 – 197Combined sources9
Helixi202 – 210Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH7NMR-A148-214[»]
ProteinModelPortaliQ9SB61
SMRiQ9SB61
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SB61

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 38Poly-Gly6

Domaini

The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 98ZF-HD dimerization-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Homeobox, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX1N Eukaryota
ENOG410YEN7 LUCA
HOGENOMiHOG000238105
InParanoidiQ9SB61
OMAiRAHRVPT
OrthoDBiEOG09360PCW
PhylomeDBiQ9SB61

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR006455 Homeodomain_ZF_HD
IPR006456 ZF_HD_homeobox_Cys/His_dimer
PfamiView protein in Pfam
PF04770 ZF-HD_dimer, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD125774 ZF_HD_N, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
TIGRFAMsiTIGR01565 homeo_ZF_HD, 1 hit
TIGR01566 ZF_HD_prot_N, 1 hit
PROSITEiView protein in PROSITE
PS51523 ZF_HD_DIMER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SB61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEDQEEDM EMSGVNPPCG YDSLSGEGAT SSGGGGVGRS KGVGAKIRYR
60 70 80 90 100
ECLKNHAVNI GGHAVDGCCE FMPSGEDGTL DALKCAACGC HRNFHRKETE
110 120 130 140 150
SIGGRAHRVP TYYNRPPQPH QPPGYLHLTS PAAPYRPPAA SGDEEDTSNP
160 170 180 190 200
SSSGGTTKRF RTKFTAEQKE KMLAFAERLG WRIQKHDDVA VEQFCAETGV
210 220
RRQVLKIWMH NNKNSLGKKP
Length:220
Mass (Da):24,023
Last modified:May 1, 2000 - v1
Checksum:i9E8F5BF68AA06897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035356 Genomic DNA Translation: CAA22997.1
AL161561 Genomic DNA Translation: CAB79376.1
CP002687 Genomic DNA Translation: AEE84939.1
AF439841 mRNA Translation: AAL27510.1
AY125563 mRNA Translation: AAM78073.1
PIRiT05568
RefSeqiNP_194197.1, NM_118599.2
UniGeneiAt.2543

Genome annotation databases

EnsemblPlantsiAT4G24660.1; AT4G24660.1; AT4G24660
GeneIDi828568
GrameneiAT4G24660.1; AT4G24660.1; AT4G24660
KEGGiath:AT4G24660

Similar proteinsi

Entry informationi

Entry nameiZHD2_ARATH
AccessioniPrimary (citable) accession number: Q9SB61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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