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Protein

Probable phospholipid-transporting ATPase 11

Gene

ALA11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei429 – 42914-aspartylphosphate intermediateBy similarity
Metal bindingi866 – 8661MagnesiumBy similarity
Metal bindingi870 – 8701MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G13210-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 111 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA111 Publication
Alternative name(s):
Aminophospholipid flippase 111 Publication
Gene namesi
Name:ALA111 Publication
Ordered Locus Names:At1g13210Imported
ORF Names:F3F19.24Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G13210.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9322HelicalSequence analysisAdd
BLAST
Topological domaini94 – 974ExtracellularSequence analysis
Transmembranei98 – 12023HelicalSequence analysisAdd
BLAST
Topological domaini121 – 303183CytoplasmicSequence analysisAdd
BLAST
Transmembranei304 – 32522HelicalSequence analysisAdd
BLAST
Topological domaini326 – 36338ExtracellularSequence analysisAdd
BLAST
Transmembranei364 – 38118HelicalSequence analysisAdd
BLAST
Topological domaini382 – 921540CytoplasmicSequence analysisAdd
BLAST
Transmembranei922 – 94120HelicalSequence analysisAdd
BLAST
Topological domaini942 – 95514ExtracellularSequence analysisAdd
BLAST
Transmembranei956 – 97520HelicalSequence analysisAdd
BLAST
Topological domaini976 – 100530CytoplasmicSequence analysisAdd
BLAST
Transmembranei1006 – 102823HelicalSequence analysisAdd
BLAST
Topological domaini1029 – 104113ExtracellularSequence analysisAdd
BLAST
Transmembranei1042 – 106423HelicalSequence analysisAdd
BLAST
Topological domaini1065 – 10706CytoplasmicSequence analysis
Transmembranei1071 – 109121HelicalSequence analysisAdd
BLAST
Topological domaini1092 – 110817ExtracellularSequence analysisAdd
BLAST
Transmembranei1109 – 113325HelicalSequence analysisAdd
BLAST
Topological domaini1134 – 120370CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: GOC
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • trans-Golgi network Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12031203Probable phospholipid-transporting ATPase 11PRO_0000046395Add
BLAST

Proteomic databases

PaxDbiQ9SAF5.
PRIDEiQ9SAF5.

Expressioni

Gene expression databases

GenevisibleiQ9SAF5. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G13210.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SAF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9SAF5.
KOiK01530.
OMAiAPNDEEM.
PhylomeDBiQ9SAF5.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SAF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKCRRRRLH LSNIYAFKGR KSNFQEDHSH IGGPGFSRVV YCNEPNSPAA
60 70 80 90 100
ERRNYVGNYV RSTKYTLASF IPKSLFEQFR RVANFYFLVT GVLSLTALSP
110 120 130 140 150
YSPISALLPL TFVIAASMVK EAIEDWGRKK QDIEMNNRKV KVHDGNGIFR
160 170 180 190 200
REGWRDLKVG NIVRVEKDEF FPADLLLLSS SYEDSICYVE TMNLDGETNL
210 220 230 240 250
KVKQGLEATS SALHEDSDFK ELKAVVKCED PNADLYTFVG TLHFEEQRLP
260 270 280 290 300
LSITQLLLRD SKLRNTEYIY GVVVFTGHDT KVIQNSTDPP SKRSRIERKM
310 320 330 340 350
DKIIYLMFGV VFLMSFIGSI VFGIETREDR VRNGGRTERW YLRPDNADIF
360 370 380 390 400
FDPDRAPMAA VYHFFTAVML YSYFIPISLY VSIEIVKVLQ SLFINNDILM
410 420 430 440 450
YYEENDKPAH ARTSNLNEEL GMVDTILSDK TGTLTCNSME FIKCSIAGTA
460 470 480 490 500
YGRGITEVER SMAMRSNGSS LVGDDLDVVV DQSGPKIKGF NFLDERVMKG
510 520 530 540 550
NWVKQRDAAV LQKFFRLLAV CHTAIPETDE ATGSVSYEAE SPDEAAFVVA
560 570 580 590 600
AREFGFEFFS RTQNGISFRE LDLASGKTVE RVYRLLNVLE FNSARKRMSV
610 620 630 640 650
IVRDEDGRLL LLSKGADNVM FERLAKNGRK FEEKTREHVN EYADAGLRTL
660 670 680 690 700
ILAYREVDEN EYIEFSKNFN EAKNSVTADR ESLIDEITEQ MERDLILLGA
710 720 730 740 750
TAVEDKLQNG VPDCIDKLAQ AGIKIWVLTG DKMETAINIG FACSLLRQEM
760 770 780 790 800
KQIIINLETP HIKALEKAGE KDAIEHASRE SVVNQMEEGK ALLTASSSAS
810 820 830 840 850
SHEAFALIID GKSLTYALED DFKKKFLDLA TGCASVICCR SSPKQKALVT
860 870 880 890 900
RLVKSGTGKT TLAIGDGAND VGMLQEADIG VGISGVEGMQ AVMSSDIAIA
910 920 930 940 950
QFRYLERLLL VHGHWCYSRI SSMICYFFYK NITFGVTVFL YEAYTSFSAQ
960 970 980 990 1000
PAYNDWFLSL FNVFFSSLPV IALGVFDQDV SARYCYKFPL LYQEGVQNLL
1010 1020 1030 1040 1050
FSWKRIIGWM FNGVFTALAI FFLCKESLKH QLYNPNGKTA GREILGGTMY
1060 1070 1080 1090 1100
TCVVWVVNLQ MALAISYFTW LQHIVIWGSV AFWYIFLMIY GAITPSFSTD
1110 1120 1130 1140 1150
AYKVFIEALA PAPSYWLTTL FVMFFALIPF FVFKSVQMRF FPGYHQMIQW
1160 1170 1180 1190 1200
IRYEGHSNDP EFVEMVRQRS IRPTTVGFTA RRAASVRRSG RFHDQLNKNF

IAF
Length:1,203
Mass (Da):136,584
Last modified:May 1, 2000 - v1
Checksum:iD06ED2FBA046FC6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007357 Genomic DNA. Translation: AAD31074.1.
CP002684 Genomic DNA. Translation: AEE28985.1.
AY099862 mRNA. Translation: AAM20713.1.
PIRiF86266.
RefSeqiNP_172780.1. NM_101192.2.
UniGeneiAt.27871.

Genome annotation databases

EnsemblPlantsiAT1G13210.1; AT1G13210.1; AT1G13210.
GeneIDi837881.
GrameneiAT1G13210.1; AT1G13210.1; AT1G13210.
KEGGiath:AT1G13210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007357 Genomic DNA. Translation: AAD31074.1.
CP002684 Genomic DNA. Translation: AEE28985.1.
AY099862 mRNA. Translation: AAM20713.1.
PIRiF86266.
RefSeqiNP_172780.1. NM_101192.2.
UniGeneiAt.27871.

3D structure databases

ProteinModelPortaliQ9SAF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G13210.1.

Proteomic databases

PaxDbiQ9SAF5.
PRIDEiQ9SAF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G13210.1; AT1G13210.1; AT1G13210.
GeneIDi837881.
GrameneiAT1G13210.1; AT1G13210.1; AT1G13210.
KEGGiath:AT1G13210.

Organism-specific databases

TAIRiAT1G13210.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9SAF5.
KOiK01530.
OMAiAPNDEEM.
PhylomeDBiQ9SAF5.

Enzyme and pathway databases

BioCyciARA:AT1G13210-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9SAF5.

Gene expression databases

GenevisibleiQ9SAF5. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Inventory of the superfamily of P-type ion pumps in Arabidopsis."
    Axelsen K.B., Palmgren M.G.
    Plant Physiol. 126:696-706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiALA11_ARATH
AccessioniPrimary (citable) accession number: Q9SAF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: April 13, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.