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Protein

Ethylene-responsive transcription factor ESR1

Gene

ESR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates gene expression patterns in meristems and thus modulates organ development. Required for correct embryo patterning and cotyledon organogenesis. Modulates auxin signaling pathway in early embryos. Involved in the cytokinin signaling pathway that promotes shoot regeneration. Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi56 – 11358AP2/ERFPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • auxin-activated signaling pathway Source: UniProtKB-KW
  • cotyledon development Source: TAIR
  • cytokinin-activated signaling pathway Source: UniProtKB-KW
  • embryonic pattern specification Source: TAIR
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • organ morphogenesis Source: TAIR
  • response to cytokinin Source: TAIR
  • specification of organ axis polarity Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Auxin signaling pathway, Cytokinin signaling pathway, Ethylene signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor ESR1
Alternative name(s):
Protein DORNROSCHEN
Protein ENHANCER OF SHOOT REGENERATION 1
Gene namesi
Name:ESR1
Synonyms:DRN, ERF089
Ordered Locus Names:At1g12980
ORF Names:F3F19.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G12980.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Ethylene-responsive transcription factor ESR1PRO_0000297927Add
BLAST

Proteomic databases

PaxDbiQ9SAD4.
PRIDEiQ9SAD4.

Expressioni

Tissue specificityi

Expressed in shoot apical and floral meristems, and in organ primordia. Transient expression during shoot regeneration.3 Publications

Developmental stagei

First observed in the embryo at four-cell stage. At the globular stage, localized in cotyledons primordia. Later confined to embryonic cotyledons tips. Expressed from embryogenesis onward in the central zone of the shoot apical and floral meristems, in organ anlagen, and (transiently) in the distal domains of organ primordia.2 Publications

Inductioni

By cytokinins.1 Publication

Interactioni

Subunit structurei

Interacts with class 3 HD-ZIP proteins such as ATHB-8, CNA, PHB, PHV, and REV.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATHB-9O042925EBI-1536756,EBI-1536772
BIM1Q9LEZ34EBI-1536756,EBI-617095

Protein-protein interaction databases

BioGridi23096. 3 interactions.
IntActiQ9SAD4. 2 interactions.
STRINGi3702.AT1G12980.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SAD4.
SMRiQ9SAD4. Positions 57-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 AP2/ERF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J198. Eukaryota.
ENOG410YQHU. LUCA.
HOGENOMiHOG000112399.
InParanoidiQ9SAD4.
OMAiNESFFPE.
OrthoDBiEOG09360QU2.

Family and domain databases

Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SAD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKALRNFTE STHSPDPNPL TKFFTEPTAS PVSRNRKLSS KDTTVTIAGA
60 70 80 90 100
GSSTTRYRGV RRRPWGRYAA EIRDPMSKER RWLGTFDTAE QAACAYDSAA
110 120 130 140 150
RAFRGAKART NFTYPTAVIM PEPRFSFSNK KSSPSARCPL PSLPLDSSTQ
160 170 180 190 200
NFYGAPAAQR IYNTQSIFLR DASCSSRKTT PYNNSFNGSS SSYSASKTAC
210 220 230 240 250
VSYSENENNE SFFPEESSDT GLLQEVVQEF LKKNRGVPPS PPTPPPVTSH
260 270 280 290 300
HDNSGYFSNL TIYSENMVQE TKETLSSKLD RYGNFQANDD GVRAVADGGL
310 320
SLGSNEWGYQ EMLMYGTQLG CTCRRSWG
Length:328
Mass (Da):36,319
Last modified:May 1, 2000 - v1
Checksum:i66320534B5FCAE6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591N → A in AAL56226 (PubMed:11752375).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353577 mRNA. Translation: AAL56226.1.
AC007357 Genomic DNA. Translation: AAD31052.1.
CP002684 Genomic DNA. Translation: AEE28956.1.
PIRiG86263.
RefSeqiNP_172758.1. NM_101169.3.
UniGeneiAt.28308.

Genome annotation databases

EnsemblPlantsiAT1G12980.1; AT1G12980.1; AT1G12980.
GeneIDi837856.
GrameneiAT1G12980.1; AT1G12980.1; AT1G12980.
KEGGiath:AT1G12980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353577 mRNA. Translation: AAL56226.1.
AC007357 Genomic DNA. Translation: AAD31052.1.
CP002684 Genomic DNA. Translation: AEE28956.1.
PIRiG86263.
RefSeqiNP_172758.1. NM_101169.3.
UniGeneiAt.28308.

3D structure databases

ProteinModelPortaliQ9SAD4.
SMRiQ9SAD4. Positions 57-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23096. 3 interactions.
IntActiQ9SAD4. 2 interactions.
STRINGi3702.AT1G12980.1.

Proteomic databases

PaxDbiQ9SAD4.
PRIDEiQ9SAD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G12980.1; AT1G12980.1; AT1G12980.
GeneIDi837856.
GrameneiAT1G12980.1; AT1G12980.1; AT1G12980.
KEGGiath:AT1G12980.

Organism-specific databases

TAIRiAT1G12980.

Phylogenomic databases

eggNOGiENOG410J198. Eukaryota.
ENOG410YQHU. LUCA.
HOGENOMiHOG000112399.
InParanoidiQ9SAD4.
OMAiNESFFPE.
OrthoDBiEOG09360QU2.

Miscellaneous databases

PROiQ9SAD4.

Family and domain databases

Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_ARATH
AccessioniPrimary (citable) accession number: Q9SAD4
Secondary accession number(s): Q8W258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

'Dornroeschen' means 'Sleeping beauty' in German.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.