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Protein

1-aminocyclopropane-1-carboxylate synthase 11

Gene

ACS11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.

Miscellaneous

The stability of ACS proteins, and the regulation of such stability, play a central role in ethylene biosynthesis.

Catalytic activityi

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.1 Publication

Cofactori

Kineticsi

  1. KM=25 µM for AdoMet
  1. Vmax=25.20 µM/h/mg enzyme

pH dependencei

Optimum pH is 8.

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 1 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4), 1-aminocyclopropane-1-carboxylate synthase 8 (ACS8), 1-aminocyclopropane-1-carboxylate synthase 2 (ACS2), 1-aminocyclopropane-1-carboxylate synthase 7 (ACS7), 1-aminocyclopropane-1-carboxylate synthase 11 (ACS11), 1-aminocyclopropane-1-carboxylate synthase 9 (ACS9), 1-aminocyclopropane-1-carboxylate synthase 6 (ACS6), 1-aminocyclopropane-1-carboxylate synthase 5 (ACS5)
  2. 1-aminocyclopropane-1-carboxylate oxidase 2 (ACO2), 1-aminocyclopropane-1-carboxylate oxidase 3 (At1g12010), 1-aminocyclopropane-1-carboxylate oxidase 4 (ACO4), 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1), 1-aminocyclopropane-1-carboxylate oxidase 5 (At1g77330)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45SubstrateBy similarity1
Binding sitei83SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processEthylene biosynthesis, Fruit ripening
LigandPyridoxal phosphate, S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ9S9U6
UniPathwayiUPA00384; UER00562

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase 11 (EC:4.4.1.14)
Short name:
ACC synthase 11
Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase 11
Gene namesi
Name:ACS11
Ordered Locus Names:At4g08040
ORF Names:T17A2.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G08040
TAIRilocus:2134485 AT4G08040

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239051 – 4601-aminocyclopropane-1-carboxylate synthase 11Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysineBy similarity1

Post-translational modificationi

May be processed at its C-terminus.

Proteomic databases

PaxDbiQ9S9U6
PRIDEiQ9S9U6

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Inductioni

By indole-3-acetic acid (IAA) and cycloheximide (CHX).1 Publication

Gene expression databases

ExpressionAtlasiQ9S9U6 baseline and differential
GenevisibleiQ9S9U6 AT

Interactioni

Subunit structurei

Homodimer and heterodimer. In vivo, the relevance of heterodimerization with other ACS enzymes is however unsure (By similarity). Interacts with GRF3.By similarity1 Publication

Protein-protein interaction databases

BioGridi11617, 1 interactor
IntActiQ9S9U6, 1 interactor
STRINGi3702.AT4G08040.1

Structurei

3D structure databases

ProteinModelPortaliQ9S9U6
SMRiQ9S9U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256 Eukaryota
COG0436 LUCA
HOGENOMiHOG000011234
InParanoidiQ9S9U6
KOiK01762
OMAiWSRIHIV
OrthoDBiEOG093608EZ
PhylomeDBiQ9S9U6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S9U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSKVVGDS HGQDSSYFLG WQEYEKNPFH ESFNTSGIVQ MGLAENQLSF
60 70 80 90 100
DLIEKWLEEH PEVLGLKKND ESVFRQLALF QDYHGLPAFK DAMAKFMGKI
110 120 130 140 150
RENKVKFDTN KMVLTAGSTS ANETLMFCLA NPGDAFLIPA PYYPGFDRDL
160 170 180 190 200
KWRTGVEIVP IHCVSSNGYK ITEDALEDAY ERALKHNLNV KGVLITNPSN
210 220 230 240 250
PLGTSTTREE LDLLLTFTST KKIHMVSDEI YSGTVFDSPE FTSVLEVAKD
260 270 280 290 300
KNMGLDGKIH VVYSLSKDLG LPGFRVGLIY SNNEKVVSAA TKMSSFGLIS
310 320 330 340 350
SQTQHLLANL LSDERFTTNY LEENKKRLRE RKDRLVSGLK EAGISCLKSN
360 370 380 390 400
AGLFCWVDLR HLLKSNTFEA EHSLWTKIVC EVGLNISPGS SCHCDEPGWF
410 420 430 440 450
RVCFANMSDQ TMEVAMDRVK GFVDNNNGGK QKRTMWDTRR RSLINKWVSK
460
LSSVTCESER
Length:460
Mass (Da):51,799
Last modified:May 1, 2000 - v1
Checksum:i1A056347680E7E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160183 Genomic DNA Translation: AAD48074.1
AL161509 Genomic DNA Translation: CAB81141.1
CP002687 Genomic DNA Translation: AEE82593.1
AF332405 mRNA Translation: AAG48768.1
PIRiB85079
RefSeqiNP_567330.1, NM_116873.2
UniGeneiAt.4151

Genome annotation databases

EnsemblPlantsiAT4G08040.1; AT4G08040.1; AT4G08040
GeneIDi826317
GrameneiAT4G08040.1; AT4G08040.1; AT4G08040
KEGGiath:AT4G08040

Similar proteinsi

Entry informationi

Entry namei1A111_ARATH
AccessioniPrimary (citable) accession number: Q9S9U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health