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Protein

Vacuolar protein sorting-associated protein 28 homolog 2

Gene

VPS28-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 28 homolog 2
Gene namesi
Name:VPS28-2
Ordered Locus Names:At4g05000
ORF Names:T32N4.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G05000
TAIRilocus:2138426 AT4G05000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209551 – 210Vacuolar protein sorting-associated protein 28 homolog 2Add BLAST210

Proteomic databases

PaxDbiQ9S9T7
PRIDEiQ9S9T7

Expressioni

Gene expression databases

ExpressionAtlasiQ9S9T7 baseline and differential
GenevisibleiQ9S9T7 AT

Interactioni

Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37. Interacts with ELC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS37-1Q9SCP93EBI-3865335,EBI-3865264

Protein-protein interaction databases

BioGridi11153, 7 interactors
IntActiQ9S9T7, 3 interactors
STRINGi3702.AT4G05000.1

Structurei

3D structure databases

ProteinModelPortaliQ9S9T7
SMRiQ9S9T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 99VPS28 N-terminalPROSITE-ProRule annotationAdd BLAST99
Domaini109 – 205VPS28 C-terminalPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the VPS28 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3284 Eukaryota
ENOG4111IQ4 LUCA
HOGENOMiHOG000203818
InParanoidiQ9S9T7
KOiK12184
OMAiKYRLDCP
OrthoDBiEOG09360Q4L
PhylomeDBiQ9S9T7

Family and domain databases

Gene3Di1.20.120.1130, 1 hit
1.20.1440.200, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR007143 Vps28
IPR017899 VPS28_C
IPR037206 VPS28_C_sf
IPR017898 VPS28_N
IPR038358 VPS28_N_sf
PANTHERiPTHR12937 PTHR12937, 1 hit
PfamiView protein in Pfam
PF03997 VPS28, 1 hit
PIRSFiPIRSF017535 VPS28, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
SSF140427 SSF140427, 1 hit
PROSITEiView protein in PROSITE
PS51310 VPS28_C, 1 hit
PS51313 VPS28_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S9T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEVKLWNDK REREMYENFA ELFAIIKATE KLEKAYIRDL INPSEYESEC
60 70 80 90 100
QKLIVHFKTL SATLKDTVPN IERFADTYKM DCPAALYRLV TSGLPATVEH
110 120 130 140 150
RATVAASTSN SASIVAECVQ NFITSMDSLK LNMVAVDQVY PLLSDLSASL
160 170 180 190 200
NKLSILPPDF EGKTKMKEWL SRLSKMGAAD ELTEQQSRQL HFDLESSYNS
210
FMAALPKAGN
Length:210
Mass (Da):23,689
Last modified:May 29, 2007 - v2
Checksum:i8011A0DAA55DE5FC
GO

Sequence cautioni

The sequence AAD48972 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB81042 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162444 Genomic DNA Translation: AAD48972.1 Different initiation.
AL161502 Genomic DNA Translation: CAB81042.1 Different initiation.
CP002687 Genomic DNA Translation: AEE82456.1
CP002687 Genomic DNA Translation: AEE82457.1
CP002687 Genomic DNA Translation: ANM66421.1
BT015071 mRNA Translation: AAT71943.1
BT015727 mRNA Translation: AAU45225.1
AK229295 mRNA Translation: BAF01158.1
PIRiH85062
RefSeqiNP_001328317.1, NM_001340525.1
NP_567281.2, NM_116739.4
NP_974513.1, NM_202784.3
UniGeneiAt.33930
At.72595

Genome annotation databases

EnsemblPlantsiAT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000
GeneIDi825842
GrameneiAT4G05000.1; AT4G05000.1; AT4G05000
AT4G05000.2; AT4G05000.2; AT4G05000
AT4G05000.3; AT4G05000.3; AT4G05000
KEGGiath:AT4G05000

Similar proteinsi

Entry informationi

Entry nameiVP282_ARATH
AccessioniPrimary (citable) accession number: Q9S9T7
Secondary accession number(s): Q6DBF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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