Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable CCR4-associated factor 1 homolog 2

Gene

CAF1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).By similarity1 Publication

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Divalent metal cation; catalyticBy similarity1
Metal bindingi46Divalent metal cation; catalyticBy similarity1
Metal bindingi176Divalent metal cation; catalyticBy similarity1
Metal bindingi245Divalent metal cation; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable CCR4-associated factor 1 homolog 2 (EC:3.1.13.4)
Gene namesi
Name:CAF1-2
Ordered Locus Names:At1g15920
ORF Names:T24D18.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G15920
TAIRilocus:2200532 AT1G15920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003715522 – 286Probable CCR4-associated factor 1 homolog 2Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9S9P2

PTM databases

iPTMnetiQ9S9P2

Expressioni

Gene expression databases

ExpressionAtlasiQ9S9P2 baseline and differential
GenevisibleiQ9S9P2 AT

Interactioni

Subunit structurei

Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.By similarity

Protein-protein interaction databases

BioGridi23402, 1 interactor
IntActiQ9S9P2, 1 interactor
STRINGi3702.AT1G15920.1

Structurei

3D structure databases

ProteinModelPortaliQ9S9P2
SMRiQ9S9P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CAF1 family.Curated

Phylogenomic databases

eggNOGiKOG0304 Eukaryota
COG5228 LUCA
HOGENOMiHOG000173077
InParanoidiQ9S9P2
KOiK12581
OMAiLPTCGTN
OrthoDBiEOG09360HD6
PhylomeDBiQ9S9P2

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF04857 CAF1, 2 hits
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S9P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAPNPEEE DDTIEIREVW NHNLEQEMAL IEQSIDDFPY VAMDTEFPGI
60 70 80 90 100
VCKTVTANPN PNPYSIHYEY NYDTLKANVN MLKLIQLGLT LSDEKGNLPT
110 120 130 140 150
CGTNKQCIWQ FNFREFNVIS DMFALDSIEL LRKSAIDLEK NNECGVDAKR
160 170 180 190 200
FAELLMGSGV VLNDKIHWVT FHCGYDFGYL LKLLSGKELP EEISDFFDQM
210 220 230 240 250
EKFFPVVYDI KYLMGFCTNL YGGLEKIAEL LGVKRVGISH QAGSDSLLTL
260 270 280
RTFIKMKEFF FTGSLLKYSG FLFGLDNPRL LTGSKN
Length:286
Mass (Da):32,635
Last modified:May 1, 2000 - v1
Checksum:i040102518AE9DE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010924 Genomic DNA Translation: AAF18489.1
CP002684 Genomic DNA Translation: AEE29383.1
CP002684 Genomic DNA Translation: AEE29384.1
AY080754 mRNA Translation: AAL86000.1
AY114040 mRNA Translation: AAM45088.1
AK317215 mRNA Translation: BAH19897.1
PIRiF86293
RefSeqiNP_173044.1, NM_101460.3
NP_973838.1, NM_202109.3
UniGeneiAt.41908

Genome annotation databases

EnsemblPlantsiAT1G15920.1; AT1G15920.1; AT1G15920
AT1G15920.2; AT1G15920.2; AT1G15920
GeneIDi838162
GrameneiAT1G15920.1; AT1G15920.1; AT1G15920
AT1G15920.2; AT1G15920.2; AT1G15920
KEGGiath:AT1G15920

Similar proteinsi

Entry informationi

Entry nameiCAF1B_ARATH
AccessioniPrimary (citable) accession number: Q9S9P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health