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Protein

Probable CCR4-associated factor 1 homolog 2

Gene

CAF1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).By similarity1 Publication

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Divalent metal cation; catalyticBy similarity1
Metal bindingi46Divalent metal cation; catalyticBy similarity1
Metal bindingi176Divalent metal cation; catalyticBy similarity1
Metal bindingi245Divalent metal cation; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable CCR4-associated factor 1 homolog 2 (EC:3.1.13.4)
Gene namesi
Name:CAF1-2
Ordered Locus Names:At1g15920
ORF Names:T24D18.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G15920.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003715522 – 286Probable CCR4-associated factor 1 homolog 2Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9S9P2.

Expressioni

Gene expression databases

GenevisibleiQ9S9P2. AT.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.By similarity

Protein-protein interaction databases

BioGridi23402. 1 interactor.
IntActiQ9S9P2. 1 interactor.
STRINGi3702.AT1G15920.1.

Structurei

3D structure databases

ProteinModelPortaliQ9S9P2.
SMRiQ9S9P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CAF1 family.Curated

Phylogenomic databases

eggNOGiKOG0304. Eukaryota.
COG5228. LUCA.
HOGENOMiHOG000173077.
InParanoidiQ9S9P2.
KOiK12581.
OMAiREFNVIS.
OrthoDBiEOG09360HD6.
PhylomeDBiQ9S9P2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF04857. CAF1. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S9P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAPNPEEE DDTIEIREVW NHNLEQEMAL IEQSIDDFPY VAMDTEFPGI
60 70 80 90 100
VCKTVTANPN PNPYSIHYEY NYDTLKANVN MLKLIQLGLT LSDEKGNLPT
110 120 130 140 150
CGTNKQCIWQ FNFREFNVIS DMFALDSIEL LRKSAIDLEK NNECGVDAKR
160 170 180 190 200
FAELLMGSGV VLNDKIHWVT FHCGYDFGYL LKLLSGKELP EEISDFFDQM
210 220 230 240 250
EKFFPVVYDI KYLMGFCTNL YGGLEKIAEL LGVKRVGISH QAGSDSLLTL
260 270 280
RTFIKMKEFF FTGSLLKYSG FLFGLDNPRL LTGSKN
Length:286
Mass (Da):32,635
Last modified:May 1, 2000 - v1
Checksum:i040102518AE9DE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010924 Genomic DNA. Translation: AAF18489.1.
CP002684 Genomic DNA. Translation: AEE29383.1.
CP002684 Genomic DNA. Translation: AEE29384.1.
AY080754 mRNA. Translation: AAL86000.1.
AY114040 mRNA. Translation: AAM45088.1.
AK317215 mRNA. Translation: BAH19897.1.
PIRiF86293.
RefSeqiNP_173044.1. NM_101460.3.
NP_973838.1. NM_202109.3.
UniGeneiAt.41908.

Genome annotation databases

EnsemblPlantsiAT1G15920.1; AT1G15920.1; AT1G15920.
AT1G15920.2; AT1G15920.2; AT1G15920.
GeneIDi838162.
GrameneiAT1G15920.1; AT1G15920.1; AT1G15920.
AT1G15920.2; AT1G15920.2; AT1G15920.
KEGGiath:AT1G15920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010924 Genomic DNA. Translation: AAF18489.1.
CP002684 Genomic DNA. Translation: AEE29383.1.
CP002684 Genomic DNA. Translation: AEE29384.1.
AY080754 mRNA. Translation: AAL86000.1.
AY114040 mRNA. Translation: AAM45088.1.
AK317215 mRNA. Translation: BAH19897.1.
PIRiF86293.
RefSeqiNP_173044.1. NM_101460.3.
NP_973838.1. NM_202109.3.
UniGeneiAt.41908.

3D structure databases

ProteinModelPortaliQ9S9P2.
SMRiQ9S9P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23402. 1 interactor.
IntActiQ9S9P2. 1 interactor.
STRINGi3702.AT1G15920.1.

Proteomic databases

PaxDbiQ9S9P2.

Protocols and materials databases

DNASUi838162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G15920.1; AT1G15920.1; AT1G15920.
AT1G15920.2; AT1G15920.2; AT1G15920.
GeneIDi838162.
GrameneiAT1G15920.1; AT1G15920.1; AT1G15920.
AT1G15920.2; AT1G15920.2; AT1G15920.
KEGGiath:AT1G15920.

Organism-specific databases

TAIRiAT1G15920.

Phylogenomic databases

eggNOGiKOG0304. Eukaryota.
COG5228. LUCA.
HOGENOMiHOG000173077.
InParanoidiQ9S9P2.
KOiK12581.
OMAiREFNVIS.
OrthoDBiEOG09360HD6.
PhylomeDBiQ9S9P2.

Miscellaneous databases

PROiQ9S9P2.

Gene expression databases

GenevisibleiQ9S9P2. AT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF04857. CAF1. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAF1B_ARATH
AccessioniPrimary (citable) accession number: Q9S9P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.