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Protein

Aspartic proteinase-like protein 2

Gene

At1g65240

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921By similarity
Active sitei303 – 3031By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciARA:GQT-1820-MONOMER.

Protein family/group databases

MEROPSiA01.A37.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase-like protein 2 (EC:3.4.23.-)
Gene namesi
Ordered Locus Names:At1g65240
ORF Names:T23K8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G65240.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: TAIR
  • anchored component of plasma membrane Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 449426Aspartic proteinase-like protein 2PRO_0000259444Add
BLAST
Propeptidei450 – 47526Removed in mature formSequence analysisPRO_0000259445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence analysis
Lipidationi449 – 4491GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9S9K4.
PRIDEiQ9S9K4.

Expressioni

Gene expression databases

GenevisibleiQ9S9K4. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G65240.1.

Structurei

3D structure databases

ProteinModelPortaliQ9S9K4.
SMRiQ9S9K4. Positions 60-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 422349Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000006100.
InParanoidiQ9S9K4.
OMAiVKLHIVE.
PhylomeDBiQ9S9K4.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR032799. TAXi_C.
IPR032861. TAXi_N.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF14541. TAXi_C. 1 hit.
PF14543. TAXi_N. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S9K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRRKLCIV VAVFVIVIEF ASANFVFKAQ HKFAGKKKNL EHFKSHDTRR
60 70 80 90 100
HSRMLASIDL PLGGDSRVDS VGLYFTKIKL GSPPKEYHVQ VDTGSDILWI
110 120 130 140 150
NCKPCPKCPT KTNLNFRLSL FDMNASSTSK KVGCDDDFCS FISQSDSCQP
160 170 180 190 200
ALGCSYHIVY ADESTSDGKF IRDMLTLEQV TGDLKTGPLG QEVVFGCGSD
210 220 230 240 250
QSGQLGNGDS AVDGVMGFGQ SNTSVLSQLA ATGDAKRVFS HCLDNVKGGG
260 270 280 290 300
IFAVGVVDSP KVKTTPMVPN QMHYNVMLMG MDVDGTSLDL PRSIVRNGGT
310 320 330 340 350
IVDSGTTLAY FPKVLYDSLI ETILARQPVK LHIVEETFQC FSFSTNVDEA
360 370 380 390 400
FPPVSFEFED SVKLTVYPHD YLFTLEEELY CFGWQAGGLT TDERSEVILL
410 420 430 440 450
GDLVLSNKLV VYDLDNEVIG WADHNCSSSI KIKDGSGGVY SVGADNLSSA
460 470
PRLLMITKLL TILSPLIVMA FTSLA
Length:475
Mass (Da):51,828
Last modified:October 31, 2006 - v2
Checksum:i1DD9C1A5EF147BA0
GO

Sequence cautioni

The sequence AAD26876.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007230 Genomic DNA. Translation: AAD26876.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34347.1.
PIRiE96676.
RefSeqiNP_176703.1. NM_105197.2.
UniGeneiAt.11165.
At.35907.

Genome annotation databases

EnsemblPlantsiAT1G65240.1; AT1G65240.1; AT1G65240.
GeneIDi842831.
GrameneiAT1G65240.1; AT1G65240.1; AT1G65240.
KEGGiath:AT1G65240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007230 Genomic DNA. Translation: AAD26876.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34347.1.
PIRiE96676.
RefSeqiNP_176703.1. NM_105197.2.
UniGeneiAt.11165.
At.35907.

3D structure databases

ProteinModelPortaliQ9S9K4.
SMRiQ9S9K4. Positions 60-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G65240.1.

Protein family/group databases

MEROPSiA01.A37.

Proteomic databases

PaxDbiQ9S9K4.
PRIDEiQ9S9K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G65240.1; AT1G65240.1; AT1G65240.
GeneIDi842831.
GrameneiAT1G65240.1; AT1G65240.1; AT1G65240.
KEGGiath:AT1G65240.

Organism-specific databases

TAIRiAT1G65240.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000006100.
InParanoidiQ9S9K4.
OMAiVKLHIVE.
PhylomeDBiQ9S9K4.

Enzyme and pathway databases

BioCyciARA:GQT-1820-MONOMER.

Miscellaneous databases

PROiQ9S9K4.

Gene expression databases

GenevisibleiQ9S9K4. AT.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR032799. TAXi_C.
IPR032861. TAXi_N.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF14541. TAXi_C. 1 hit.
PF14543. TAXi_N. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
    Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.
    J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiASPL2_ARATH
AccessioniPrimary (citable) accession number: Q9S9K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 6, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.