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Protein

Agglutinin beta-4 chain

Gene
N/A
Organism
Artocarpus integer (Jack fruit) (Artocarpus integrifolia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB
  2. IgA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

IgA-binding protein, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Agglutinin beta-4 chain
Alternative name(s):
Jacalin beta-4 chain
OrganismiArtocarpus integer (Jack fruit) (Artocarpus integrifolia)
Taxonomic identifieri3490 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesMoraceaeArtocarpus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Agglutinin beta-4 chainPRO_0000072799Add
BLAST

Interactioni

Subunit structurei

Tetramer of four alpha chains associated with two or four beta chains.By similarity

Structurei

Secondary structure

1
20
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 167Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AK4X-ray1.65B/D/F/H/J/L/N/P1-19[»]
4AKBX-ray1.95B/D/F/H1-19[»]
4AKCX-ray2.30B/D/F/H1-19[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the jacalin lectin family.Sequence Analysis

Sequencei

Sequence statusi: Fragment.

Q9S8T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
NEQSGISQTV IVGPWGAQVT
Length:20
Mass (Da):2,071
Last modified:April 30, 2000 - v1
Checksum:i8D5AE975F4D0E212
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 2011 Publication

Sequence databases

PIRiS29636.

Cross-referencesi

Sequence databases

PIRiS29636.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AK4X-ray1.65B/D/F/H/J/L/N/P1-19[»]
4AKBX-ray1.95B/D/F/H1-19[»]
4AKCX-ray2.30B/D/F/H1-19[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The alpha- and beta-subunits of the jacalins are cleavage products from a 17-kDa precursor."
    Ngoc L.D., Brillard M., Hoebeke J.
    Biochim. Biophys. Acta 1156:219-222(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiLECB4_ARTIN
AccessioniPrimary (citable) accession number: Q9S8T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2006
Last sequence update: April 30, 2000
Last modified: October 28, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.