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Protein

Sulfite oxidase

Gene

SOX

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in sulfite oxidative detoxification.

Caution

Lacks the conserved cytochrome b5 heme-binding domain present in other sulfite oxidases.Curated

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.1 Publication

Cofactori

Mo-molybdopterin2 PublicationsNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.2 Publications

Kineticsi

  1. KM=33.8 µM for sulfite (at pH 8.0 and 25 degrees Celsius)

    Pathwayi: sulfur metabolism

    This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
    View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi98Molybdenum1
    Binding sitei202Molybdopterin1
    Binding sitei207Molybdopterin1

    GO - Molecular functioni

    • molybdenum ion binding Source: InterPro
    • sulfite oxidase activity Source: TAIR

    GO - Biological processi

    • chlorophyll metabolic process Source: TAIR
    • nitrate assimilation Source: InterPro
    • response to sulfur dioxide Source: TAIR
    • sulfur compound metabolic process Source: TAIR

    Keywordsi

    Molecular functionOxidoreductase
    LigandMetal-binding, Molybdenum

    Enzyme and pathway databases

    BRENDAi1.8.3.1 399
    ReactomeiR-ATH-1614517 Sulfide oxidation to sulfate
    UniPathwayiUPA00096

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfite oxidase (EC:1.8.3.1)
    Alternative name(s):
    Moco-containing protein AtMCP
    Short name:
    At-SO
    Short name:
    AtSOX
    Gene namesi
    Name:SOX
    Synonyms:MCP
    Ordered Locus Names:At3g01910
    ORF Names:F1C9.31, F28J7.38
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    AraportiAT3G01910
    TAIRilocus:2078683 AT3G01910

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001660771 – 393Sulfite oxidaseAdd BLAST393

    Proteomic databases

    PaxDbiQ9S850
    PRIDEiQ9S850

    Expressioni

    Gene expression databases

    ExpressionAtlasiQ9S850 baseline and differential
    GenevisibleiQ9S850 AT

    Interactioni

    Subunit structurei

    Predominantly monomer; also homodimer.2 Publications

    Protein-protein interaction databases

    BioGridi5452, 2 interactors
    IntActiQ9S850, 1 interactor
    STRINGi3702.AT3G01910.1

    Structurei

    Secondary structure

    1393
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi8 – 10Combined sources3
    Beta strandi21 – 24Combined sources4
    Turni25 – 28Combined sources4
    Beta strandi29 – 31Combined sources3
    Helixi34 – 37Combined sources4
    Helixi45 – 47Combined sources3
    Beta strandi58 – 60Combined sources3
    Beta strandi66 – 75Combined sources10
    Beta strandi78 – 80Combined sources3
    Helixi81 – 85Combined sources5
    Beta strandi89 – 97Combined sources9
    Turni99 – 102Combined sources4
    Helixi103 – 109Combined sources7
    Beta strandi122 – 131Combined sources10
    Helixi132 – 137Combined sources6
    Turni138 – 140Combined sources3
    Beta strandi154 – 160Combined sources7
    Helixi164 – 166Combined sources3
    Beta strandi172 – 176Combined sources5
    Helixi177 – 181Combined sources5
    Helixi183 – 185Combined sources3
    Beta strandi188 – 193Combined sources6
    Turni200 – 205Combined sources6
    Beta strandi207 – 209Combined sources3
    Helixi215 – 217Combined sources3
    Beta strandi221 – 230Combined sources10
    Helixi235 – 238Combined sources4
    Beta strandi239 – 241Combined sources3
    Turni250 – 252Combined sources3
    Helixi255 – 257Combined sources3
    Beta strandi267 – 270Combined sources4
    Beta strandi275 – 279Combined sources5
    Beta strandi281 – 291Combined sources11
    Beta strandi298 – 306Combined sources9
    Beta strandi315 – 322Combined sources8
    Beta strandi326 – 328Combined sources3
    Beta strandi337 – 347Combined sources11
    Beta strandi349 – 357Combined sources9
    Helixi367 – 370Combined sources4
    Beta strandi382 – 388Combined sources7

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1OGPX-ray2.60A/B/C/D/E/F1-393[»]
    ProteinModelPortaliQ9S850
    SMRiQ9S850
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9S850

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni10 – 242Moco domainAdd BLAST233
    Regioni49 – 53Molybdopterin-binding5
    Regioni159 – 161Molybdopterin-binding3
    Regioni218 – 220Molybdopterin-binding3
    Regioni243 – 393HomodimerizationAdd BLAST151

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi391 – 393Microbody targeting signalSequence analysis3

    Phylogenomic databases

    eggNOGiKOG0535 Eukaryota
    COG2041 LUCA
    HOGENOMiHOG000252609
    InParanoidiQ9S850
    KOiK00387
    OMAiAVGNAKW
    OrthoDBiEOG09360ATQ
    PhylomeDBiQ9S850

    Family and domain databases

    Gene3Di3.90.420.10, 1 hit
    InterProiView protein in InterPro
    IPR014756 Ig_E-set
    IPR005066 MoCF_OxRdtse_dimer
    IPR008335 Mopterin_OxRdtase_euk
    IPR000572 OxRdtase_Mopterin-bd_dom
    IPR036374 OxRdtase_Mopterin-bd_sf
    PfamiView protein in Pfam
    PF03404 Mo-co_dimer, 1 hit
    PF00174 Oxidored_molyb, 1 hit
    PRINTSiPR00407 EUMOPTERIN
    SUPFAMiSSF56524 SSF56524, 1 hit
    SSF81296 SSF81296, 1 hit

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

    Note: A number of isoforms are produced. According to EST sequences.
    Isoform 1 (identifier: Q9S850-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MPGIRGPSEY SQEPPRHPSL KVNAKEPFNA EPPRSALVSS YVTPVDLFYK
    60 70 80 90 100
    RNHGPIPIVD HLQSYSVTLT GLIQNPRKLF IKDIRSLPKY NVTATLQCAG
    110 120 130 140 150
    NRRTAMSKVR NVRGVGWDVS AIGNAVWGGA KLADVLELVG IPKLTASTNL
    160 170 180 190 200
    GARHVEFVSV DRCKEENGGP YKASITLSQA TNPEADVLLA YEMNGETLNR
    210 220 230 240 250
    DHGFPLRVVV PGVIGARSVK WLDSINVIAE ESQGFFMQKD YKMFPPSVNW
    260 270 280 290 300
    DNINWSSRRP QMDFPVQSAI CSVEDVQMVK PGKVSIKGYA VSGGGRGIER
    310 320 330 340 350
    VDISLDGGKN WVEASRTQEP GKQYISEHSS SDKWAWVLFE ATIDVSQTTE
    360 370 380 390
    VIAKAVDSAA NVQPENVESV WNLRGVLNTS WHRVLLRLGH SNL
    Length:393
    Mass (Da):43,329
    Last modified:May 1, 2000 - v1
    Checksum:i00B4AC49E92C5DD2
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti206L → S in AAF13276 (PubMed:11598126).Curated1
    Sequence conflicti251D → H in AAF13276 (PubMed:11598126).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200972 mRNA Translation: AAF13276.1
    AB071965 mRNA Translation: BAC10904.1
    AC010797 Genomic DNA Translation: AAF03458.1
    AC011664 Genomic DNA Translation: AAF14844.1
    CP002686 Genomic DNA Translation: AEE73732.1
    AF360247 mRNA Translation: AAK25957.1
    AY133863 mRNA Translation: AAM91797.1
    RefSeqiNP_186840.1, NM_111057.4 [Q9S850-1]
    UniGeneiAt.24506
    At.48610

    Genome annotation databases

    EnsemblPlantsiAT3G01910.1; AT3G01910.1; AT3G01910 [Q9S850-1]
    GeneIDi820118
    GrameneiAT3G01910.1; AT3G01910.1; AT3G01910 [Q9S850-1]
    KEGGiath:AT3G01910

    Keywords - Coding sequence diversityi

    Alternative splicing

    Similar proteinsi

    Entry informationi

    Entry nameiSUOX_ARATH
    AccessioniPrimary (citable) accession number: Q9S850
    Secondary accession number(s): Q9SNW2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 1, 2000
    Last modified: April 25, 2018
    This is version 132 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health