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Protein

Sulfite oxidase

Gene

SOX

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in sulfite oxidative detoxification.

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.1 Publication

Cofactori

Mo-molybdopterin2 PublicationsNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.2 Publications

Kineticsi

  1. KM=33.8 µM for sulfite (at pH 8.0 and 25 degrees Celsius)

    Pathwayi: sulfur metabolism

    This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
    View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi98Molybdenum1
    Binding sitei202Molybdopterin1
    Binding sitei207Molybdopterin1

    GO - Molecular functioni

    • molybdenum ion binding Source: InterPro
    • sulfite oxidase activity Source: TAIR

    GO - Biological processi

    • chlorophyll metabolic process Source: TAIR
    • nitrate assimilation Source: InterPro
    • response to sulfur dioxide Source: TAIR
    • sulfur compound metabolic process Source: TAIR
    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, Molybdenum

    Enzyme and pathway databases

    BRENDAi1.8.3.1. 399.
    ReactomeiR-ATH-1614517. Sulfide oxidation to sulfate.
    UniPathwayiUPA00096.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfite oxidase (EC:1.8.3.1)
    Alternative name(s):
    Moco-containing protein AtMCP
    Short name:
    At-SO
    Short name:
    AtSOX
    Gene namesi
    Name:SOX
    Synonyms:MCP
    Ordered Locus Names:At3g01910
    ORF Names:F1C9.31, F28J7.38
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 3

    Organism-specific databases

    TAIRiAT3G01910.

    Subcellular locationi

    GO - Cellular componenti

    • mitochondrion Source: TAIR
    • peroxisome Source: TAIR
    Complete GO annotation...

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001660771 – 393Sulfite oxidaseAdd BLAST393

    Proteomic databases

    PaxDbiQ9S850.
    PRIDEiQ9S850.

    Expressioni

    Gene expression databases

    ExpressionAtlasiQ9S850. baseline and differential.
    GenevisibleiQ9S850. AT.

    Interactioni

    Subunit structurei

    Predominantly monomer; also homodimer.2 Publications

    Protein-protein interaction databases

    BioGridi5452. 2 interactors.
    IntActiQ9S850. 1 interactor.
    STRINGi3702.AT3G01910.1.

    Structurei

    Secondary structure

    1393
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi8 – 10Combined sources3
    Beta strandi21 – 24Combined sources4
    Turni25 – 28Combined sources4
    Beta strandi29 – 31Combined sources3
    Helixi34 – 37Combined sources4
    Helixi45 – 47Combined sources3
    Beta strandi58 – 60Combined sources3
    Beta strandi66 – 75Combined sources10
    Beta strandi78 – 80Combined sources3
    Helixi81 – 85Combined sources5
    Beta strandi89 – 97Combined sources9
    Turni99 – 102Combined sources4
    Helixi103 – 109Combined sources7
    Beta strandi122 – 131Combined sources10
    Helixi132 – 137Combined sources6
    Turni138 – 140Combined sources3
    Beta strandi154 – 160Combined sources7
    Helixi164 – 166Combined sources3
    Beta strandi172 – 176Combined sources5
    Helixi177 – 181Combined sources5
    Helixi183 – 185Combined sources3
    Beta strandi188 – 193Combined sources6
    Turni200 – 205Combined sources6
    Beta strandi207 – 209Combined sources3
    Helixi215 – 217Combined sources3
    Beta strandi221 – 230Combined sources10
    Helixi235 – 238Combined sources4
    Beta strandi239 – 241Combined sources3
    Turni250 – 252Combined sources3
    Helixi255 – 257Combined sources3
    Beta strandi267 – 270Combined sources4
    Beta strandi275 – 279Combined sources5
    Beta strandi281 – 291Combined sources11
    Beta strandi298 – 306Combined sources9
    Beta strandi315 – 322Combined sources8
    Beta strandi326 – 328Combined sources3
    Beta strandi337 – 347Combined sources11
    Beta strandi349 – 357Combined sources9
    Helixi367 – 370Combined sources4
    Beta strandi382 – 388Combined sources7

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1OGPX-ray2.60A/B/C/D/E/F1-393[»]
    ProteinModelPortaliQ9S850.
    SMRiQ9S850.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9S850.

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni10 – 242Moco domainAdd BLAST233
    Regioni49 – 53Molybdopterin-binding5
    Regioni159 – 161Molybdopterin-binding3
    Regioni218 – 220Molybdopterin-binding3
    Regioni243 – 393HomodimerizationAdd BLAST151

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi391 – 393Microbody targeting signalSequence analysis3

    Phylogenomic databases

    eggNOGiKOG0535. Eukaryota.
    COG2041. LUCA.
    HOGENOMiHOG000252609.
    InParanoidiQ9S850.
    KOiK00387.
    OMAiPVDLFYK.
    OrthoDBiEOG09360ATQ.
    PhylomeDBiQ9S850.

    Family and domain databases

    Gene3Di2.60.40.650. 1 hit.
    3.90.420.10. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    [Graphical view]
    PfamiPF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view]
    PRINTSiPR00407. EUMOPTERIN.
    SUPFAMiSSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

    Note: A number of isoforms are produced. According to EST sequences.
    Isoform 1 (identifier: Q9S850-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MPGIRGPSEY SQEPPRHPSL KVNAKEPFNA EPPRSALVSS YVTPVDLFYK
    60 70 80 90 100
    RNHGPIPIVD HLQSYSVTLT GLIQNPRKLF IKDIRSLPKY NVTATLQCAG
    110 120 130 140 150
    NRRTAMSKVR NVRGVGWDVS AIGNAVWGGA KLADVLELVG IPKLTASTNL
    160 170 180 190 200
    GARHVEFVSV DRCKEENGGP YKASITLSQA TNPEADVLLA YEMNGETLNR
    210 220 230 240 250
    DHGFPLRVVV PGVIGARSVK WLDSINVIAE ESQGFFMQKD YKMFPPSVNW
    260 270 280 290 300
    DNINWSSRRP QMDFPVQSAI CSVEDVQMVK PGKVSIKGYA VSGGGRGIER
    310 320 330 340 350
    VDISLDGGKN WVEASRTQEP GKQYISEHSS SDKWAWVLFE ATIDVSQTTE
    360 370 380 390
    VIAKAVDSAA NVQPENVESV WNLRGVLNTS WHRVLLRLGH SNL
    Length:393
    Mass (Da):43,329
    Last modified:May 1, 2000 - v1
    Checksum:i00B4AC49E92C5DD2
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti206L → S in AAF13276 (PubMed:11598126).Curated1
    Sequence conflicti251D → H in AAF13276 (PubMed:11598126).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200972 mRNA. Translation: AAF13276.1.
    AB071965 mRNA. Translation: BAC10904.1.
    AC010797 Genomic DNA. Translation: AAF03458.1.
    AC011664 Genomic DNA. Translation: AAF14844.1.
    CP002686 Genomic DNA. Translation: AEE73732.1.
    AF360247 mRNA. Translation: AAK25957.1.
    AY133863 mRNA. Translation: AAM91797.1.
    RefSeqiNP_186840.1. NM_111057.4. [Q9S850-1]
    UniGeneiAt.24506.
    At.48610.

    Genome annotation databases

    EnsemblPlantsiAT3G01910.1; AT3G01910.1; AT3G01910. [Q9S850-1]
    GeneIDi820118.
    GrameneiAT3G01910.1; AT3G01910.1; AT3G01910.
    KEGGiath:AT3G01910.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200972 mRNA. Translation: AAF13276.1.
    AB071965 mRNA. Translation: BAC10904.1.
    AC010797 Genomic DNA. Translation: AAF03458.1.
    AC011664 Genomic DNA. Translation: AAF14844.1.
    CP002686 Genomic DNA. Translation: AEE73732.1.
    AF360247 mRNA. Translation: AAK25957.1.
    AY133863 mRNA. Translation: AAM91797.1.
    RefSeqiNP_186840.1. NM_111057.4. [Q9S850-1]
    UniGeneiAt.24506.
    At.48610.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1OGPX-ray2.60A/B/C/D/E/F1-393[»]
    ProteinModelPortaliQ9S850.
    SMRiQ9S850.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi5452. 2 interactors.
    IntActiQ9S850. 1 interactor.
    STRINGi3702.AT3G01910.1.

    Proteomic databases

    PaxDbiQ9S850.
    PRIDEiQ9S850.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT3G01910.1; AT3G01910.1; AT3G01910. [Q9S850-1]
    GeneIDi820118.
    GrameneiAT3G01910.1; AT3G01910.1; AT3G01910.
    KEGGiath:AT3G01910.

    Organism-specific databases

    TAIRiAT3G01910.

    Phylogenomic databases

    eggNOGiKOG0535. Eukaryota.
    COG2041. LUCA.
    HOGENOMiHOG000252609.
    InParanoidiQ9S850.
    KOiK00387.
    OMAiPVDLFYK.
    OrthoDBiEOG09360ATQ.
    PhylomeDBiQ9S850.

    Enzyme and pathway databases

    UniPathwayiUPA00096.
    BRENDAi1.8.3.1. 399.
    ReactomeiR-ATH-1614517. Sulfide oxidation to sulfate.

    Miscellaneous databases

    EvolutionaryTraceiQ9S850.
    PROiQ9S850.

    Gene expression databases

    ExpressionAtlasiQ9S850. baseline and differential.
    GenevisibleiQ9S850. AT.

    Family and domain databases

    Gene3Di2.60.40.650. 1 hit.
    3.90.420.10. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    [Graphical view]
    PfamiPF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view]
    PRINTSiPR00407. EUMOPTERIN.
    SUPFAMiSSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSUOX_ARATH
    AccessioniPrimary (citable) accession number: Q9S850
    Secondary accession number(s): Q9SNW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 1, 2000
    Last modified: November 30, 2016
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the conserved cytochrome b5 heme-binding domain present in other sulfite oxidases.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.