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Protein

Heat stress transcription factor A-8

Gene

HSFA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 112By similarityAdd BLAST96

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371511 HSF1 activation
R-ATH-3371568 Attenuation phase
R-ATH-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor A-8
Short name:
AtHsfA8
Alternative name(s):
AtHsf-03
Heat shock factor protein 5
Short name:
HSF 5
Heat shock transcription factor 5
Short name:
HSTF 5
Gene namesi
Name:HSFA8
Synonyms:HSF03, HSF5
Ordered Locus Names:At1g67970
ORF Names:T23K23.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G67970
TAIRilocus:2200171 AT1G67970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245861 – 374Heat stress transcription factor A-8Add BLAST374

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9S7U5
PRIDEiQ9S7U5

Expressioni

Gene expression databases

ExpressionAtlasiQ9S7U5 baseline and differential
GenevisibleiQ9S7U5 AT

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi28346, 2 interactors
STRINGi3702.AT1G67970.1

Structurei

3D structure databases

ProteinModelPortaliQ9S7U5
SMRiQ9S7U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 192Hydrophobic repeat HR-A/BAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi285 – 294AHA110
Motifi298 – 303Nuclear localization signalSequence analysis6
Motifi330 – 339AHA210
Motifi363 – 370Nuclear export signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 10Poly-Gly4
Compositional biasi11 – 16Poly-Ser6
Compositional biasi291 – 294Poly-Leu4
Compositional biasi318 – 322Poly-Glu5

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motifs are transcriptional activator elements.1 Publication

Sequence similaritiesi

Belongs to the HSF family. Class A subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
HOGENOMiHOG000029171
InParanoidiQ9S7U5
KOiK09419
OMAiQPKENSW
OrthoDBiEOG09360BUI
PhylomeDBiQ9S7U5

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S7U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSTDGGGG SSSSSSVAPF LRKCYDMVDD STTDSIISWS PSADNSFVIL
60 70 80 90 100
DTTVFSVQLL PKYFKHSNFS SFIRQLNIYG FRKVDADRWE FANDGFVRGQ
110 120 130 140 150
KDLLKNVIRR KNVQSSEQSK HESTSTTYAQ EKSGLWKEVD ILKGDKQVLA
160 170 180 190 200
QELIKVRQYQ EVTDTKMLHL EDRVQGMEES QQEMLSFLVM VMKNPSLLVQ
210 220 230 240 250
LLQPKEKNTW RKAGEGAKIV EEVTDEGESN SYGLPLVTYQ PPSDNNGTAK
260 270 280 290 300
SNSNDVNDFL RNADMLKFCL DENHVPLIIP DLYDDGAWEK LLLLSPSRKK
310 320 330 340 350
TKKQENIVKK GKDDLTLEEE EEDGTMELDK SYMLKLISEE MEKPDDFEFG
360 370
QLTPERSRNL EILTEQMELL ASNE
Length:374
Mass (Da):42,630
Last modified:May 1, 2000 - v1
Checksum:i401A924CBFEEB512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251866 mRNA Translation: CAB63801.1
AC012563 Genomic DNA Translation: AAG51992.1
CP002684 Genomic DNA Translation: AEE34730.1
AY094396 mRNA Translation: AAM19775.1
PIRiF96702
RefSeqiNP_176964.1, NM_105467.4
UniGeneiAt.5972

Genome annotation databases

EnsemblPlantsiAT1G67970.1; AT1G67970.1; AT1G67970
GeneIDi843125
GrameneiAT1G67970.1; AT1G67970.1; AT1G67970
KEGGiath:AT1G67970

Similar proteinsi

Entry informationi

Entry nameiHSFA8_ARATH
AccessioniPrimary (citable) accession number: Q9S7U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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