Reviewed, UniProtKB/Swiss-Prot Q9S7T7 (SCC11_ARATH)

Names and origin

Protein names

Recommended name:
    Sister chromatid cohesion 1 protein 1
Alternative name(s):
    SCC1 homolog 1
    Protein DETERMINATE INFERTILE 1

Gene names

Name:	SYN1
Synonyms:	DIF1
Ordered Locus Names:	At5g05490
ORF Names:	MOP10.3

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids.
Subunit structure	Component of the cohesin complex By similarity.
Subcellular location	Nucleus.
Tissue specificity	Isoform 2 is expressed at low levels in buds, leaves and roots, whereas expression of isoform 1 is confined to buds.
Sequence similarities	Belongs to the rad21 family.

Ontologies

Keywords
Biological process	Cell cycle Chromosome partition Meiosis
Cellular component	Nucleus
Coding sequence diversity	Alternative promoter usage
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	attachment of spindle microtubules to kinetochore during meiosis I Inferred from mutant phenotype. Source: TAIR establishment or maintenance of chromatin architecture Inferred from mutant phenotype. Source: TAIR meiotic chromosome condensation Ref.1 Inferred from mutant phenotype. Source: TAIR meiotic sister chromatid cohesion, centromeric Inferred from mutant phenotype. Source: TAIR
Cellular component	nuclear chromosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]

Isoform 2 (identifier: Q9S7T7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9S7T7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MLRLESLIVTVWGPAT → MFYSHQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	Sister chromatid cohesion 1 protein 1		PRO_0000097875
Natural variations
	Alternative sequence	1 – 16	16	MLRLE…WGPAT → MFYSHQ in isoform 1.		VSP_007492

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified May 16, 2003. Version 2. Checksum: 05D815E914233650	FASTA	627	71,228
	10 20 30 40 50 60 MLRLESLIVT VWGPATLLAR KAPLGQIWMA ATLHAKINRK KLDKLDIIQI CEEILNPSVP 70 80 90 100 110 120 MALRLSGILM GGVVIVYERK VKLLFDDVNR FLVEINGAWR TKSVPDPTLL PKGKTHARKE 130 140 150 160 170 180 AVTLPENEEA DFGDFEQTRN VPKFGNYMDF QQTFISMRLD ESHVNNNPEP EDLGQQFHQA 190 200 210 220 230 240 DAENITLFEY HGSFQTNNET YDRFERFDIE GDDETQMNSN PREGAEIPTT LIPSPPRHHD 250 260 270 280 290 300 IPEGVNPTSP QRQEQQENRR DGFAEQMEEQ NIPDKEEHDR PQPAKKRARK TATSAMDYEQ 310 320 330 340 350 360 TIIAGHVYQS WLQDTSDILC RGEKRKVRGT IRPDMESFKR ANMPPTQLFE KDSSYPPQLY 370 380 390 400 410 420 QLWSKNTQVL QTSSSESRHP DLRAEQSPGF VQERMHNHHQ TDHHERSDTS SQNLDSPAEI 430 440 450 460 470 480 LRTVRTGKGA SVESMMAGSR ASPETINRQA ADINVTPFYS GDDVRSMPST PSARGAASIN 490 500 510 520 530 540 NIEISSKSRM PNRKRPNSSP RRGLEPVAEE RPWEHREYEF EFSMLPEKRF TADKEILFET 550 560 570 580 590 600 ASTQTQKPVC NQSDEMITDS IKSHLKTHFE TPGAPQVESL NKLAVGMDRN AAAKLFFQSC 610 620 VLATRGVIKV NQAEPYGDIL IARGPNM
	Isoform 1. Checksum: 4BE14F8524B538B6	FASTA	617	70,254
	10 20 30 40 50 60 MFYSHQLLAR KAPLGQIWMA ATLHAKINRK KLDKLDIIQI CEEILNPSVP MALRLSGILM 70 80 90 100 110 120 GGVVIVYERK VKLLFDDVNR FLVEINGAWR TKSVPDPTLL PKGKTHARKE AVTLPENEEA 130 140 150 160 170 180 DFGDFEQTRN VPKFGNYMDF QQTFISMRLD ESHVNNNPEP EDLGQQFHQA DAENITLFEY 190 200 210 220 230 240 HGSFQTNNET YDRFERFDIE GDDETQMNSN PREGAEIPTT LIPSPPRHHD IPEGVNPTSP 250 260 270 280 290 300 QRQEQQENRR DGFAEQMEEQ NIPDKEEHDR PQPAKKRARK TATSAMDYEQ TIIAGHVYQS 310 320 330 340 350 360 WLQDTSDILC RGEKRKVRGT IRPDMESFKR ANMPPTQLFE KDSSYPPQLY QLWSKNTQVL 370 380 390 400 410 420 QTSSSESRHP DLRAEQSPGF VQERMHNHHQ TDHHERSDTS SQNLDSPAEI LRTVRTGKGA 430 440 450 460 470 480 SVESMMAGSR ASPETINRQA ADINVTPFYS GDDVRSMPST PSARGAASIN NIEISSKSRM 490 500 510 520 530 540 PNRKRPNSSP RRGLEPVAEE RPWEHREYEF EFSMLPEKRF TADKEILFET ASTQTQKPVC 550 560 570 580 590 600 NQSDEMITDS IKSHLKTHFE TPGAPQVESL NKLAVGMDRN AAAKLFFQSC VLATRGVIKV 610 NQAEPYGDIL IARGPNM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of SYN1, a RAD21-like gene essential for meiosis in Arabidopsis." Bai X., Peirson B.N., Dong F., Xue C., Makaroff C.A. Plant Cell 11:417-430(1999) [PubMed: 10072401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE. Strain: cv. Wassilewskija.
[2]	"The DIF1 gene of Arabidopsis is required for meiotic chromosome segregation and belongs to the REC8/RAD21 cohesin gene family." Bhatt A.M., Lister C., Page T., Fransz P.F., Findlay K., Jones G.H., Dickinson H.G., Dean C. Plant J. 19:463-472(1999) [PubMed: 10504568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: cv. Landsberg erecta.
[3]	"Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones." Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S. DNA Res. 4:215-230(1997) [PubMed: 9330910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF080620 mRNA. Translation: AAF08982.1. AF080619 mRNA. Translation: AAF08981.1. AJ238306 mRNA. Translation: CAB64643.1. AB005241 Genomic DNA. Translation: BAB11538.1.
IPI	IPI00517990. IPI00540220.
PIR	T52571.
RefSeq	NP_850773.1.
UniGene	At.690
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	830432.
GenomeReviews	Gene locus AT5G05490 in contig BA000015_GR.
NMPDR	fig|3702.1.peg.22655.
Organism-specific databases
GeneFarm	1768.
TAIR	At5g05490.
Phylogenomic databases
OMA	Q9S7T7. ICEEILN.
Gene expression databases
ArrayExpress	Q9S7T7.
Family and domain databases
InterPro	IPR006909. Rad21/Rec8_C. IPR006910. Rad21_Rec8_N. [Graphical view]
Pfam	PF04824. Rad21_Rec8. 1 hit. PF04825. Rad21_Rec8_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCC11_ARATH

Accession

Primary (citable) accession number: Q9S7T7
Secondary accession number(s): Q3E9L1, Q9SQI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	May 16, 2003
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)