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Protein

Pentatricopeptide repeat-containing protein At1g74900, mitochondrial

Gene

OTP43

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the trans-splicing of intron 1 of the mitochondrial nad1 transcript encoding the ND1 subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).1 Publication

GO - Biological processi

  • RNA splicing Source: TAIR
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat-containing protein At1g74900, mitochondrial
Alternative name(s):
Protein ORGANELLE TRANSCRIPT PROCESSING DEFECT 43
Gene namesi
Name:OTP43
Ordered Locus Names:At1g74900
ORF Names:F25A4.13, F9E10.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G74900.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 482Pentatricopeptide repeat-containing protein At1g74900, mitochondrialPRO_0000342866
Transit peptidei1 – ?MitochondrionSequence analysis

Expressioni

Gene expression databases

ExpressionAtlasiQ9S7R4. baseline and differential.
GenevisibleiQ9S7R4. AT.

Structurei

3D structure databases

ProteinModelPortaliQ9S7R4.
SMRiQ9S7R4. Positions 85-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 12435PPR 1Add
BLAST
Repeati125 – 15935PPR 2Add
BLAST
Repeati160 – 19031PPR 3Add
BLAST
Repeati194 – 22835PPR 4Add
BLAST
Repeati229 – 26335PPR 5Add
BLAST
Repeati264 – 29835PPR 6Add
BLAST
Repeati299 – 33335PPR 7Add
BLAST
Repeati334 – 36835PPR 8Add
BLAST
Repeati369 – 40335PPR 9Add
BLAST
Repeati404 – 44138PPR 10Add
BLAST
Repeati442 – 47635PPR 11Add
BLAST

Sequence similaritiesi

Belongs to the PPR family. P subfamily.Curated
Contains 11 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

HOGENOMiHOG000083199.
InParanoidiQ9S7R4.
OMAiCPRQIAA.
OrthoDBiEOG0936084P.
PhylomeDBiQ9S7R4.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002885. Pentatricopeptide_repeat.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF01535. PPR. 1 hit.
PF12854. PPR_1. 1 hit.
PF13041. PPR_2. 3 hits.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 8 hits.
PROSITEiPS51375. PPR. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9S7R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRLFSKSLC TSAAGANLKP PPADSAAIAK LILSSPNTTH QDDQFLLSTK
60 70 80 90 100
TTPWTPNLVN SVLKRLWNHG PKALQFFHFL DNHHREYVHD ASSFDLAIDI
110 120 130 140 150
AARLHLHPTV WSLIHRMRSL RIGPSPKTFA IVAERYASAG KPDKAVKLFL
160 170 180 190 200
NMHEHGCFQD LASFNTILDV LCKSKRVEKA YELFRALRGR FSVDTVTYNV
210 220 230 240 250
ILNGWCLIKR TPKALEVLKE MVERGINPNL TTYNTMLKGF FRAGQIRHAW
260 270 280 290 300
EFFLEMKKRD CEIDVVTYTT VVHGFGVAGE IKRARNVFDE MIREGVLPSV
310 320 330 340 350
ATYNAMIQVL CKKDNVENAV VMFEEMVRRG YEPNVTTYNV LIRGLFHAGE
360 370 380 390 400
FSRGEELMQR MENEGCEPNF QTYNMMIRYY SECSEVEKAL GLFEKMGSGD
410 420 430 440 450
CLPNLDTYNI LISGMFVRKR SEDMVVAGKL LLEMVERGFI PRKFTFNRVL
460 470 480
NGLLLTGNQA FAKEILRLQS KSGSRLLRKF RL
Length:482
Mass (Da):55,082
Last modified:May 1, 2000 - v1
Checksum:i5C7CFFF96484B32F
GO
Isoform 2 (identifier: Q9S7R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-457: Missing.

Show »
Length:453
Mass (Da):51,724
Checksum:i2AAE50086CA56E55
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei429 – 45729Missing in isoform 2. 1 PublicationVSP_034551Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55286.1.
AC013258 Genomic DNA. Translation: AAG51911.1.
CP002684 Genomic DNA. Translation: AEE35645.1.
BT030379 mRNA. Translation: ABO38792.1.
PIRiF96778.
RefSeqiNP_177628.2. NM_106148.2. [Q9S7R4-2]
UniGeneiAt.20977.
At.66952.

Genome annotation databases

EnsemblPlantsiAT1G74900.1; AT1G74900.1; AT1G74900. [Q9S7R4-2]
GeneIDi843829.
KEGGiath:AT1G74900.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Arabidopsis PPR Protein Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55286.1.
AC013258 Genomic DNA. Translation: AAG51911.1.
CP002684 Genomic DNA. Translation: AEE35645.1.
BT030379 mRNA. Translation: ABO38792.1.
PIRiF96778.
RefSeqiNP_177628.2. NM_106148.2. [Q9S7R4-2]
UniGeneiAt.20977.
At.66952.

3D structure databases

ProteinModelPortaliQ9S7R4.
SMRiQ9S7R4. Positions 85-473.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G74900.1; AT1G74900.1; AT1G74900. [Q9S7R4-2]
GeneIDi843829.
KEGGiath:AT1G74900.

Organism-specific databases

TAIRiAT1G74900.

Phylogenomic databases

HOGENOMiHOG000083199.
InParanoidiQ9S7R4.
OMAiCPRQIAA.
OrthoDBiEOG0936084P.
PhylomeDBiQ9S7R4.

Miscellaneous databases

PROiQ9S7R4.

Gene expression databases

ExpressionAtlasiQ9S7R4. baseline and differential.
GenevisibleiQ9S7R4. AT.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002885. Pentatricopeptide_repeat.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF01535. PPR. 1 hit.
PF12854. PPR_1. 1 hit.
PF13041. PPR_2. 3 hits.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 8 hits.
PROSITEiPS51375. PPR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP125_ARATH
AccessioniPrimary (citable) accession number: Q9S7R4
Secondary accession number(s): A4FVT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.