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Protein

Protein TIFY 10B

Gene

TIFY10B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY10B/JAZ2 interaction. Activated by MYC2, MYC3 and MYC4 transcription factors.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processJasmonic acid signaling pathway, Plant defense, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TIFY 10B
Alternative name(s):
Jasmonate ZIM domain-containing protein 2
Gene namesi
Name:TIFY10B
Synonyms:JAZ2
Ordered Locus Names:At1g74950
ORF Names:F25A4.8, F9E10.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G74950.
TAIRilocus:2027267. AT1G74950.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003006531 – 249Protein TIFY 10BAdd BLAST249

Post-translational modificationi

Ubiquitinated. Targeted for degradation by the SCF(COI1) E3 ubiquitin ligase-proteasome pathway during jasmonate signaling.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9S7M2.

Expressioni

Tissue specificityi

Expressed in cotyledons, hypocotyls, roots, sepals, petal vascular tissue and stigmas of developing flowers. Expressed in stamen filaments after jasmonic acid treatment.1 Publication

Inductioni

Up-regulated by jasmonate, wounding and herbivory.2 Publications

Gene expression databases

ExpressionAtlasiQ9S7M2. baseline and differential.
GenevisibleiQ9S7M2. AT.

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with COI1, MYC2, MYC3, MYC4, AFPH2/NINJA, TIFY10A/JAZ1, TIFY6B/JAZ3, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY7/JAZ9, TIFY9/JAZ10, TIFY3A/JAZ11 and TIFY3B/JAZ12.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MYC2Q392042EBI-1792563,EBI-1792336

Protein-protein interaction databases

BioGridi29053. 20 interactors.
DIPiDIP-52214N.
ELMiQ9S7M2.
IntActiQ9S7M2. 3 interactors.
STRINGi3702.AT1G74950.1.

Structurei

3D structure databases

SMRiQ9S7M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 148TifyPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 95Poly-Ser9

Domaini

The jas domain (203-228) is required for interaction with COI1.By similarity

Sequence similaritiesi

Belongs to the TIFY/JAZ family.Curated

Phylogenomic databases

eggNOGiENOG410IZA3. Eukaryota.
ENOG410ZDCD. LUCA.
HOGENOMiHOG000239787.
InParanoidiQ9S7M2.
KOiK13464.
OMAiPCEASGM.
OrthoDBiEOG09360N2V.
PhylomeDBiQ9S7M2.

Family and domain databases

InterProiView protein in InterPro
IPR018467. CCT_CS.
IPR010399. Tify_dom.
PfamiView protein in Pfam
PF09425. CCT_2. 1 hit.
PF06200. tify. 1 hit.
SMARTiView protein in SMART
SM00979. TIFY. 1 hit.
PROSITEiView protein in PROSITE
PS51320. TIFY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSAECWD FSGRKPSFSQ TCTRLSRYLK EKGSFGDLSL GMTCKPDVNG
60 70 80 90 100
GSRQPTMMNL FPCEASGMDS SAGQEDIKPK TMFPRQSSFS SSSSSGTKED
110 120 130 140 150
VQMIKETTKS VKPESQSAPL TIFYGGRVMV FDDFSAEKAK EVIDLANKGS
160 170 180 190 200
AKSFTCFTAE VNNNHSAYSQ KEIASSPNPV CSPAKTAAQE PIQPNPASLA
210 220 230 240
CELPIARRAS LHRFLEKRKD RITSKAPYQI DGSAEASSKP TNPAWLSSR
Length:249
Mass (Da):27,072
Last modified:May 1, 2000 - v1
Checksum:i7410B2A50505A543
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31E → D in AAM64554 (Ref. 4) Curated1
Sequence conflicti195N → K in AAM64554 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55281.1.
AC013258 Genomic DNA. Translation: AAG51928.1.
CP002684 Genomic DNA. Translation: AEE35654.1.
AF344319 mRNA. Translation: AAK06870.1.
AF386959 mRNA. Translation: AAK62404.1.
BT006301 mRNA. Translation: AAP13409.1.
AY086993 mRNA. Translation: AAM64554.1.
PIRiC96779.
RefSeqiNP_565096.1. NM_106153.4.
UniGeneiAt.19896.

Genome annotation databases

EnsemblPlantsiAT1G74950.1; AT1G74950.1; AT1G74950.
GeneIDi843834.
GrameneiAT1G74950.1; AT1G74950.1; AT1G74950.
KEGGiath:AT1G74950.

Similar proteinsi

Entry informationi

Entry nameiTI10B_ARATH
AccessioniPrimary (citable) accession number: Q9S7M2
Secondary accession number(s): Q8LBU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families