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Q9S7J8

- HMA7_ARATH

UniProt

Q9S7J8 - HMA7_ARATH

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Protein
Copper-transporting ATPase RAN1
Gene
RAN1, HMA7, At5g44790, K23L20.14, T19K24.18
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in copper import into the cell. Essential for ethylene signaling, which requires copper. Acts by delivering copper to create functional hormone receptors.

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Copper Reviewed prediction
Metal bindingi70 – 701Copper Reviewed prediction
Metal bindingi144 – 1441Copper Reviewed prediction
Metal bindingi147 – 1471Copper Reviewed prediction
Active sitei658 – 65814-aspartylphosphate intermediate By similarity
Metal bindingi877 – 8771Magnesium By similarity
Metal bindingi881 – 8811Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. copper ion binding Source: InterPro
  4. copper ion transmembrane transporter activity Source: TAIR

GO - Biological processi

  1. copper ion transmembrane transport Source: GOC
  2. ethylene-activated signaling pathway Source: TAIR
  3. regulation of stomatal movement Source: TAIR
  4. response to ethylene Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ethylene signaling pathway, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G44790-MONOMER.

Protein family/group databases

TCDBi3.A.3.5.32. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase RAN1 (EC:3.6.3.54)
Alternative name(s):
Protein HEAVY METAL ATPASE 7
Protein RESPONSIVE TO ANTAGONIST 1
Gene namesi
Name:RAN1
Synonyms:HMA7
Ordered Locus Names:At5g44790
ORF Names:K23L20.14, T19K24.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G44790.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 298298Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei299 – 32022Helical; Reviewed prediction
Add
BLAST
Topological domaini321 – 33818Extracellular Reviewed prediction
Add
BLAST
Transmembranei339 – 35820Helical; Reviewed prediction
Add
BLAST
Topological domaini359 – 3657Cytoplasmic Reviewed prediction
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Topological domaini387 – 40317Extracellular Reviewed prediction
Add
BLAST
Transmembranei404 – 42421Helical; Reviewed prediction
Add
BLAST
Topological domaini425 – 558134Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei559 – 58123Helical; Reviewed prediction
Add
BLAST
Topological domaini582 – 60221Extracellular Reviewed prediction
Add
BLAST
Transmembranei603 – 62018Helical; Reviewed prediction
Add
BLAST
Topological domaini621 – 931311Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei932 – 95120Helical; Reviewed prediction
Add
BLAST
Topological domaini952 – 96312Extracellular Reviewed prediction
Add
BLAST
Transmembranei964 – 98219Helical; Reviewed prediction
Add
BLAST
Topological domaini983 – 100119Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: TAIR
  2. endosome Source: TAIR
  3. integral component of membrane Source: UniProtKB-KW
  4. trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi173 – 1731G → E in ran1-2.
Mutagenesisi497 – 4971T → I in ran1-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001Copper-transporting ATPase RAN1
PRO_0000046402Add
BLAST

Proteomic databases

PaxDbiQ9S7J8.
PRIDEiQ9S7J8.

Expressioni

Gene expression databases

GenevestigatoriQ9S7J8.

Interactioni

Protein-protein interaction databases

BioGridi19759. 1 interaction.
IntActiQ9S7J8. 2 interactions.
MINTiMINT-8066708.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 638
Helixi68 – 7912
Beta strandi84 – 907
Helixi91 – 933
Beta strandi95 – 1006
Turni102 – 1043
Helixi107 – 11711
Beta strandi120 – 1267

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DXSX-ray1.70X56-128[»]
ProteinModelPortaliQ9S7J8.
SMRiQ9S7J8. Positions 55-270, 291-986.

Miscellaneous databases

EvolutionaryTraceiQ9S7J8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 12367HMA 1
Add
BLAST
Domaini134 – 20067HMA 2
Add
BLAST
Domaini208 – 27467HMA 3; degenerate
Add
BLAST

Sequence similaritiesi

Contains 3 HMA domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217.
HOGENOMiHOG000250397.
InParanoidiQ9S7J8.
KOiK17686.
OMAiMSIMYLA.
PhylomeDBiQ9S7J8.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 3 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9S7J8-1 [UniParc]FASTAAdd to Basket

« Hide

MAPSRRDLQL TPVTGGSSSQ ISDMEEVGLL DSYHNEANAD DILTKIEEGR     50
DVSGLRKIQV GVTGMTCAAC SNSVEAALMN VNGVFKASVA LLQNRADVVF 100
DPNLVKEEDI KEAIEDAGFE AEILAEEQTQ ATLVGQFTIG GMTCAACVNS 150
VEGILRDLPG VKRAVVALST SLGEVEYDPN VINKDDIVNA IEDAGFEGSL 200
VQSNQQDKLV LRVDGILNEL DAQVLEGILT RLNGVRQFRL DRISGELEVV 250
FDPEVVSSRS LVDGIEEDGF GKFKLRVMSP YERLSSKDTG EASNMFRRFI 300
SSLVLSIPLF FIQVICPHIA LFDALLVWRC GPFMMGDWLK WALVSVIQFV 350
IGKRFYVAAW RALRNGSTNM DVLVALGTSA SYFYSVGALL YGAVTGFWSP 400
TYFDASAMLI TFVLLGKYLE SLAKGKTSDA MKKLVQLTPA TAILLTEGKG 450
GKLVGEREID ALLIQPGDTL KVHPGAKIPA DGVVVWGSSY VNESMVTGES 500
VPVSKEVDSP VIGGTINMHG ALHMKATKVG SDAVLSQIIS LVETAQMSKA 550
PIQKFADYVA SIFVPVVITL ALFTLVGWSI GGAVGAYPDE WLPENGTHFV 600
FSLMFSISVV VIACPCALGL ATPTAVMVAT GVGATNGVLI KGGDALEKAH 650
KVKYVIFDKT GTLTQGKATV TTTKVFSEMD RGEFLTLVAS AEASSEHPLA 700
KAIVAYARHF HFFDESTEDG ETNNKDLQNS GWLLDTSDFS ALPGKGIQCL 750
VNEKMILVGN RKLMSENAIN IPDHVEKFVE DLEESGKTGV IVAYNGKLVG 800
VMGIADPLKR EAALVVEGLL RMGVRPIMVT GDNWRTARAV AKEVGIEDVR 850
AEVMPAGKAD VIRSLQKDGS TVAMVGDGIN DSPALAAADV GMAIGAGTDV 900
AIEAADYVLM RNNLEDVITA IDLSRKTLTR IRLNYVFAMA YNVVSIPIAA 950
GVFFPVLRVQ LPPWAAGACM ALSSVSVVCS SLLLRRYKKP RLTTVLKITT 1000
E 1001
Length:1,001
Mass (Da):107,395
Last modified:May 1, 2000 - v1
Checksum:i7E820909C60D5B0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091112 Genomic DNA. Translation: AAD29115.1.
AF082565 mRNA. Translation: AAD29109.1.
AB016874 Genomic DNA. Translation: BAB08832.1.
AC002342 Genomic DNA. Translation: AAC79141.2.
CP002688 Genomic DNA. Translation: AED95163.1.
RefSeqiNP_199292.1. NM_123847.2.
UniGeneiAt.24482.

Genome annotation databases

EnsemblPlantsiAT5G44790.1; AT5G44790.1; AT5G44790.
GeneIDi834509.
KEGGiath:AT5G44790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091112 Genomic DNA. Translation: AAD29115.1 .
AF082565 mRNA. Translation: AAD29109.1 .
AB016874 Genomic DNA. Translation: BAB08832.1 .
AC002342 Genomic DNA. Translation: AAC79141.2 .
CP002688 Genomic DNA. Translation: AED95163.1 .
RefSeqi NP_199292.1. NM_123847.2.
UniGenei At.24482.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DXS X-ray 1.70 X 56-128 [» ]
ProteinModelPortali Q9S7J8.
SMRi Q9S7J8. Positions 55-270, 291-986.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 19759. 1 interaction.
IntActi Q9S7J8. 2 interactions.
MINTi MINT-8066708.

Protein family/group databases

TCDBi 3.A.3.5.32. the p-type atpase (p-atpase) superfamily.

Proteomic databases

PaxDbi Q9S7J8.
PRIDEi Q9S7J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G44790.1 ; AT5G44790.1 ; AT5G44790 .
GeneIDi 834509.
KEGGi ath:AT5G44790.

Organism-specific databases

TAIRi AT5G44790.

Phylogenomic databases

eggNOGi COG2217.
HOGENOMi HOG000250397.
InParanoidi Q9S7J8.
KOi K17686.
OMAi MSIMYLA.
PhylomeDBi Q9S7J8.

Enzyme and pathway databases

BioCyci ARA:AT5G44790-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9S7J8.
PROi Q9S7J8.

Gene expression databases

Genevestigatori Q9S7J8.

Family and domain databases

Gene3Di 2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF55008. SSF55008. 3 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Responsive-to-antagonist 1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis."
    Hirayama T., Kieber J.J., Hirayama N., Kogan M., Guzman P., Nourizadeh S., Alonso J.M., Dailey W.P., Dancis A., Ecker J.R.
    Cell 97:383-393(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], MUTAGENESIS.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
    Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiHMA7_ARATH
AccessioniPrimary (citable) accession number: Q9S7J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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