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Protein

Polyribonucleotide nucleotidyltransferase 2, mitochondrial

Gene

PNP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the 3'-end maturation of mitochondrial mRNAs, rRNAs and tRNAs. Functions as a poly(A) mRNA 3'-5' degrading phosphorylase and is required for the degradation of highly expressed transcripts of non-coding regions.2 Publications

Miscellaneous

Plants silencing PNP2 stop growing after two to three weeks.1 Publication

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: UniProtKB
  • polyribonucleotide nucleotidyltransferase activity Source: UniProtKB
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial RNA catabolic process Source: UniProtKB
  • mitochondrial RNA processing Source: UniProtKB
  • mRNA catabolic process Source: InterPro
  • mRNA processing Source: UniProtKB-KW
  • rRNA processing Source: UniProtKB-KW
  • tRNA processing Source: UniProtKB-KW

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-binding, Transferase
Biological processmRNA processing, rRNA processing, tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase 2, mitochondrial (EC:2.7.7.8)
Short name:
AtmtPNPase
Alternative name(s):
Polynucleotide phosphorylase 2
Short name:
PNPase 2
Gene namesi
Name:PNP2
Ordered Locus Names:At5g14580
ORF Names:T15N1.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G14580
TAIRilocus:2222662 AT5G14580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_500102836440 – 991Polyribonucleotide nucleotidyltransferase 2, mitochondrialAdd BLAST952

Proteomic databases

PaxDbiQ9S7G6
PRIDEiQ9S7G6

Expressioni

Gene expression databases

ExpressionAtlasiQ9S7G6 baseline and differential
GenevisibleiQ9S7G6 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G14580.1

Structurei

3D structure databases

ProteinModelPortaliQ9S7G6
SMRiQ9S7G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini609 – 667KHAdd BLAST59
Domaini678 – 746S1 motif 1Add BLAST69
Domaini925 – 987S1 motif 2Add BLAST63

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1067 Eukaryota
COG1185 LUCA
HOGENOMiHOG000218327
InParanoidiQ9S7G6
KOiK00962
OMAiHEVQIMV
OrthoDBiEOG0936088V
PhylomeDBiQ9S7G6

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 2 hits
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S7G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIVNRASS ASLPNFLAWR ALGFRTICSG RLGFAPSVPD SPVSAGTKIL
60 70 80 90 100
ESFKEEFEVG SRVVSFETGK IARFANGSVV LGMDETKVLS TVTCAKTDSP
110 120 130 140 150
RDFLPLTVDY QEKQYAQGLI PNTYMRREGA PKERELLCGR LIDRPIRPLF
160 170 180 190 200
PTGFYHEVQI MASVLSSDGK QDPDILAANA SSAALMLSDV PWGGPIGVIR
210 220 230 240 250
IGRICGQFVV NPTMDELSSS DLNLIYACTR DKTMMIDVQS REISEKDLAA
260 270 280 290 300
ALRLAHPEAV KYLDPQIRLA EKAGKQKKEY KLSMLSDKTL EKVADLAATR
310 320 330 340 350
IESVFTDPSY GKFERGEALD NIGKDVRKVF EEEGDQESLS ILPKAVDTVR
360 370 380 390 400
KKVVRSRMIS DGFRVDGRHV DEVRPIYCES HYLPALHGSA LFSRGDTQVL
410 420 430 440 450
CTVTLGAPAE AQSLDSLVGP PKKRFMLHYS FPPYCTNEVG KRGGLNRREV
460 470 480 490 500
GHGTLAEKAL LAVLPPEEAF PYTIRINSEV MSSDGSTSMA SVCGGSMALM
510 520 530 540 550
DAGIPLRAHV AGVSVGLITD VDPSSGEIKD YRIVTDILGL EDHLGDMDFK
560 570 580 590 600
IAGTRDGVTA IQLDIKPAGI PLDIVCESLE NAREARLQIL DHMERNINSP
610 620 630 640 650
RGQDGAYSPR LATLKYSNDS LRTLIGPMGV LKRKIEVETG ARLSIDNGTL
660 670 680 690 700
TIVAKNQDVM EKAQEQVDFI IGRELVVGGV YKGTVSSIKE YGAFVEFPGG
710 720 730 740 750
QQGLLHMSEL SHEPVSKVSD VLDIGQCITT MCIETDVRGN IKLSRKALLP
760 770 780 790 800
KPKRKPASDA GKDPVMKESS TVYIENSSVG EIVASMPSIV TPLQKSRLSV
810 820 830 840 850
PAVVIRTAVE CNEAEKSSPV NDNDKPRRAA TSKPDRKPKS TASKLIATQK
860 870 880 890 900
EEEALESIAP EETSAECGEI LKQDGKLKSV SPKNNSTASN LVSFSKAKKS
910 920 930 940 950
TMKENLSENK AEESASVSTR KLKIGTEMTA TVDHVRALGL VLDLGGEIRG
960 970 980 990
MYIFQGDKDK FKKGDTLRVK CTSFNTKGVP VMALVDEEGE E
Length:991
Mass (Da):107,772
Last modified:May 1, 2000 - v1
Checksum:i9557E25980C6D1A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14685 mRNA Translation: CAB43864.1
Y14686 Genomic DNA Translation: CAB43865.1
AL163792 Genomic DNA Translation: CAB87625.1
CP002688 Genomic DNA Translation: AED92050.1
PIRiT48631
RefSeqiNP_196962.1, NM_121462.4
UniGeneiAt.427

Genome annotation databases

EnsemblPlantsiAT5G14580.1; AT5G14580.1; AT5G14580
GeneIDi831309
GrameneiAT5G14580.1; AT5G14580.1; AT5G14580
KEGGiath:AT5G14580

Similar proteinsi

Entry informationi

Entry nameiPNP2_ARATH
AccessioniPrimary (citable) accession number: Q9S7G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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