Q9S7D9 (ACCR1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase-like protein CCR1
EC=2.7.11.1

Alternative name(s):
Protein CRINKLY 4 RELATED 1
Short name=AtCRR1

Gene names

Name:	CCR1
Synonyms:	CRR1
Ordered Locus Names:	At3g09780
ORF Names:	F11F8.37, F8A24.17

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	775 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine-protein kinase with low activity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Ref.4
Subunit structure	Homodimer. Ref.5
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in roots, leaves, shoot apical meristems (SAM), and floral buds. Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. Contains 1 TNFR-Cys repeat.
Sequence caution	The sequence BX824605 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein homodimerization activity Inferred from direct assay Ref.5. Source: UniProtKB protein kinase activity Inferred from direct assay Ref.4. Source: UniProtKB protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 775	752	Serine/threonine-protein kinase-like protein CCR1		PRO_0000382746
Regions
	Topological domain	24 – 439	416	Extracellular Potential
	Transmembrane	440 – 460	21	Helical; Potential
	Topological domain	461 – 775	315	Cytoplasmic Potential
	Repeat	351 – 406	56	TNFR-Cys
	Domain	520 – 770	251	Protein kinase
	Nucleotide binding	526 – 534	9	ATP By similarity
	Compositional bias	59 – 116	58	Ser-rich
Sites
	Active site	645	1	Proton acceptor By similarity
	Binding site	548	1	ATP By similarity
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	241	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	292	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential
	Glycosylation	360	1	N-linked (GlcNAc...) Potential
	Glycosylation	414	1	N-linked (GlcNAc...) Potential
	Disulfide bond	352 ↔ 381		By similarity
	Disulfide bond	384 ↔ 398		By similarity
	Disulfide bond	388 ↔ 406		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S7D9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A4615BFE756B74DA	FASTA	775	84,185
	10 20 30 40 50 60 METRCSLLFL SLILLYLPKP GSGFGSSGPI AASFGGSAFF CAIDASGRQD VICWGKNYSS 70 80 90 100 110 120 PSSPSSSSSS SSIASSTSAS YNIPSMAVLS GGDGFLCGIL SNTSQAFCFS SLGSSSGMDL 130 140 150 160 170 180 VPLAYRTTAY SQIAAGNSHV CAVRGAYYSD HDSGTIDCWE ITRATNNNSL IAKENPNFYD 190 200 210 220 230 240 QIVSNLVFNN IVSGDGFSCG GIRDGGMLCF GPNSSNLGFN TTSDNFQVLA AGKNSVCAIL 250 260 270 280 290 300 NLSREVKCWG EDESFVNSPM NDSRFVSLTA GPRHFCGIRE DNHEVECWGN SNFSLIPKGS 310 320 330 340 350 360 GFKAIASSDF IVCGIREEDL VLDCWMVNGS STLAYDPPLE LCSPGMCRAG PCNEKEFAFN 370 380 390 400 410 420 ASILNEPDLT SLCVRKELMV CSPCGSDCSH GFFLSSSCTA NSDRICTPCS LCQNSSCSDI 430 440 450 460 470 480 CKLHNSNFPD KHWHQLQRLV LIIGSCASAL LIIIIGCCVV PRIVTSPNKE DGAANQFKSC 490 500 510 520 530 540 IGKPDLDTDQ PLENVSPAPS VTPFAQVFRL SELKDATNGF KEFNELGRGS YGFVYKAVLA 550 560 570 580 590 600 DGRQVAVKRA NAATIIHTNT REFETELEIL CNIRHCNIVN LLGYSTEMGE RLLVYEYMPH 610 620 630 640 650 660 GTLHDHLHSG FSPLSWSLRI KIAMQTAKGL EYLHNEAEPR IIHGDVKSSN VLLDSEWVAR 670 680 690 700 710 720 VADFGLVTSS NEKNLDIKRD VYDFGVVLLE ILTGRKRYDR DCDPPEIVEW TVPVIREGKA 730 740 750 760 770 AAIVDTYIAL PRNVEPLLKL ADVAELCVRE DPNQQPTMSE LANWLEHVAR DALIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation." Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M. Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Molecular analysis of the CRINKLY4 gene family in Arabidopsis thaliana." Cao X., Li K., Suh S.-G., Guo T., Becraft P.W. Planta 220:645-657(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
[5]	"Dimerization properties of the transmembrane domains of Arabidopsis CRINKLY4 receptor-like kinase and homologs." Stokes K.D., Gururaj Rao A. Arch. Biochem. Biophys. 477:219-226(2008) [PubMed] [Europe PMC] [Abstract] Cited for: HOMODIMERIZATION.
[6]	"Diverse transcriptional programs associated with environmental stress and hormones in the Arabidopsis receptor-like kinase gene family." Chae L., Sudat S., Dudoit S., Zhu T., Luan S. Mol. Plant 2:84-107(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Web resources

PlantP kinase Classification PPC

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC015985 Genomic DNA. Translation: AAF23257.1. AC016661 Genomic DNA. Translation: AAF23306.1. CP002686 Genomic DNA. Translation: AEE74812.1. BX824605 mRNA. No translation available.
IPI	IPI00539708.
RefSeq	NP_187589.1. NM_111813.3.
UniGene	At.40041.
3D structure databases
ProteinModelPortal	Q9S7D9.
SMR	Q9S7D9. Positions 508-766.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT3G09780.1-P.
Proteomic databases
PRIDE	Q9S7D9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G09780.1; AT3G09780.1; AT3G09780.
GeneID	820136.
KEGG	ath:AT3G09780.
Organism-specific databases
GeneFarm	2043. 161.
TAIR	At3g09780.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000115148.
InParanoid	Q9S7D9.
OMA	CGIREDN.
PhylomeDB	Q9S7D9.
ProtClustDB	CLSN2683247.
Gene expression databases
Genevestigator	Q9S7D9.
Family and domain databases
Gene3D	2.130.10.30. 2 hits.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR009091. RCC1/BLIP-II. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. IPR001368. TNFR/NGFR_Cys_rich_reg. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50985. RCC1/BLIP-II. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCR1_ARATH

Accession

Primary (citable) accession number: Q9S7D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program