Q9S795 (BADH1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Betaine aldehyde dehydrogenase 1, chloroplastic
Short name=BADH
EC=1.2.1.8

Alternative name(s):
Aldehyde dehydrogenase family 10 member A8

Gene names

Name:	ALDH10A8
Ordered Locus Names:	At1g74920
ORF Names:	F25A4.11, F9E10.23

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: UniProtKB-UniPathway response to salt stress Inferred from mutant phenotype PubMed 21053011. Source: TAIR response to water deprivation Inferred from mutant phenotype PubMed 21053011. Source: TAIR
Cellular_component	cell wall Inferred from direct assay PubMed 16287169. Source: TAIR chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from direct assay PubMed 21166475. Source: TAIR leucoplast Inferred from direct assay PubMed 21053011. Source: TAIR
Molecular_function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9S795-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 7	7	Chloroplast Potential
	Chain	8 – 501	494	Betaine aldehyde dehydrogenase 1, chloroplastic		PRO_0000007179
Regions
	Nucleotide binding	238 – 243	6	NAD By similarity
Sites
	Active site	260	1	Proton acceptor By similarity
	Active site	294	1	Nucleophile By similarity
	Site	162	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BA8B03C28C22453B	FASTA	501	54,432
	10 20 30 40 50 60 MAIPMPTRQL FIDGEWREPI LKKRIPIVNP ATEEVIGDIP AATTEDVDVA VNAARRALSR 70 80 90 100 110 120 NKGKDWAKAP GAVRAKYLRA IAAKVNERKT DLAKLEALDC GKPLDEAVWD MDDVAGCFEF 130 140 150 160 170 180 YADLAEGLDA KQKAPVSLPM ESFKSYVLKQ PLGVVGLITP WNYPLLMAVW KVAPSLAAGC 190 200 210 220 230 240 TAILKPSELA SVTCLELADI CREVGLPPGV LNVLTGFGSE AGAPLASHPG VDKIAFTGSF 250 260 270 280 290 300 ATGSKVMTAA AQLVKPVSME LGGKSPLIVF DDVDLDKAAE WALFGCFWTN GQICSATSRL 310 320 330 340 350 360 LVHESIASEF IEKLVKWSKN IKISDPMEEG CRLGPVVSKG QYEKILKFIS TAKSEGATIL 370 380 390 400 410 420 HGGSRPEHLE KGFFIEPTII TDVTTSMQIW REEVFGPVLC VKTFASEDEA IELANDSHYG 430 440 450 460 470 480 LGAAVISNDT ERCDRISEAF EAGIVWINCS QPCFTQAPWG GVKRSGFGRE LGEWGLDNYL 490 500 SVKQVTLYTS NDPWGWYKSP N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-501. Strain: cv. Columbia.
[6]	"The ALDH gene superfamily of Arabidopsis." Kirch H.-H., Bartels D., Wei Y., Schnable P.S., Wood A.J. Trends Plant Sci. 9:371-377(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008263 Genomic DNA. Translation: AAD55284.1. AC013258 Genomic DNA. Translation: AAG51938.1. CP002684 Genomic DNA. Translation: AEE35649.1. AY093071 mRNA. Translation: AAM13070.1. BT008872 mRNA. Translation: AAP68311.1. AY087395 mRNA. Translation: AAM64944.1. AK220905 mRNA. Translation: BAD94340.1.
IPI	IPI00547056.
PIR	H96778.
RefSeq	NP_565094.1. NM_106150.3.
UniGene	At.26779.
3D structure databases
ProteinModelPortal	Q9S795.
SMR	Q9S795. Positions 4-500.
ModBase	Search...
Proteomic databases
PaxDb	Q9S795.
PRIDE	Q9S795.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G74920.1; AT1G74920.1; AT1G74920.
GeneID	843831.
KEGG	ath:AT1G74920.
Organism-specific databases
TAIR	At1g74920.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
InParanoid	Q9S795.
KO	K00130.
OMA	DEAVWDM.
PhylomeDB	Q9S795.
ProtClustDB	PLN02467.
Enzyme and pathway databases
UniPathway	UPA00529; UER00386.
Gene expression databases
ArrayExpress	Q9S795.
Genevestigator	Q9S795.
GermOnline	AT1G74920. Arabidopsis thaliana.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH1_ARATH

Accession

Primary (citable) accession number: Q9S795
Secondary accession number(s): Q56ZQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program