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Protein

Betaine aldehyde dehydrogenase 1, chloroplastic

Gene

ALDH10A8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine aldehyde dehydrogenase 1, chloroplastic (ALDH10A8)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Transition state stabilizerBy similarity1
Active sitei260Proton acceptorPROSITE-ProRule annotation1
Active sitei294NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi238 – 243NADBy similarity6

GO - Molecular functioni

GO - Biological processi

  • glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT1G74920-MONOMER.
BRENDAi1.2.1.8. 399.
ReactomeiR-ATH-71262. Carnitine synthesis.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase 1, chloroplastic (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 10 member A8
Gene namesi
Name:ALDH10A8
Ordered Locus Names:At1g74920
ORF Names:F25A4.11, F9E10.23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G74920.
TAIRilocus:2027186. AT1G74920.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • chloroplast Source: UniProtKB-SubCell
  • cytosol Source: TAIR
  • leucoplast Source: TAIR

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 7ChloroplastSequence analysis7
ChainiPRO_00000071798 – 501Betaine aldehyde dehydrogenase 1, chloroplasticAdd BLAST494

Proteomic databases

PaxDbiQ9S795.

PTM databases

iPTMnetiQ9S795.

Expressioni

Gene expression databases

ExpressionAtlasiQ9S795. baseline and differential.
GenevisibleiQ9S795. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G74920.1.

Structurei

3D structure databases

ProteinModelPortaliQ9S795.
SMRiQ9S795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
InParanoidiQ9S795.
KOiK00130.
OMAiSFGYTRR.
OrthoDBiEOG093606WE.
PhylomeDBiQ9S795.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9S795-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIPMPTRQL FIDGEWREPI LKKRIPIVNP ATEEVIGDIP AATTEDVDVA
60 70 80 90 100
VNAARRALSR NKGKDWAKAP GAVRAKYLRA IAAKVNERKT DLAKLEALDC
110 120 130 140 150
GKPLDEAVWD MDDVAGCFEF YADLAEGLDA KQKAPVSLPM ESFKSYVLKQ
160 170 180 190 200
PLGVVGLITP WNYPLLMAVW KVAPSLAAGC TAILKPSELA SVTCLELADI
210 220 230 240 250
CREVGLPPGV LNVLTGFGSE AGAPLASHPG VDKIAFTGSF ATGSKVMTAA
260 270 280 290 300
AQLVKPVSME LGGKSPLIVF DDVDLDKAAE WALFGCFWTN GQICSATSRL
310 320 330 340 350
LVHESIASEF IEKLVKWSKN IKISDPMEEG CRLGPVVSKG QYEKILKFIS
360 370 380 390 400
TAKSEGATIL HGGSRPEHLE KGFFIEPTII TDVTTSMQIW REEVFGPVLC
410 420 430 440 450
VKTFASEDEA IELANDSHYG LGAAVISNDT ERCDRISEAF EAGIVWINCS
460 470 480 490 500
QPCFTQAPWG GVKRSGFGRE LGEWGLDNYL SVKQVTLYTS NDPWGWYKSP

N
Length:501
Mass (Da):54,432
Last modified:May 1, 2000 - v1
Checksum:iBA8B03C28C22453B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55284.1.
AC013258 Genomic DNA. Translation: AAG51938.1.
CP002684 Genomic DNA. Translation: AEE35649.1.
AY093071 mRNA. Translation: AAM13070.1.
BT008872 mRNA. Translation: AAP68311.1.
AY087395 mRNA. Translation: AAM64944.1.
AK220905 mRNA. Translation: BAD94340.1.
PIRiH96778.
RefSeqiNP_565094.1. NM_106150.4. [Q9S795-1]
UniGeneiAt.26779.

Genome annotation databases

EnsemblPlantsiAT1G74920.1; AT1G74920.1; AT1G74920. [Q9S795-1]
GeneIDi843831.
GrameneiAT1G74920.1; AT1G74920.1; AT1G74920.
KEGGiath:AT1G74920.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBADH1_ARATH
AccessioniPrimary (citable) accession number: Q9S795
Secondary accession number(s): Q56ZQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families