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Protein

Betaine aldehyde dehydrogenase 1, chloroplastic

Gene

ALDH10A8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei162 – 1621Transition state stabilizerBy similarity
Active sitei260 – 2601Proton acceptorPROSITE-ProRule annotation
Active sitei294 – 2941NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi238 – 2436NADBy similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: GO_Central

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
  2. response to salt stress Source: TAIR
  3. response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT1G74920-MONOMER.
ARA:GQT-15-MONOMER.
ReactomeiREACT_230585. Carnitine synthesis.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase 1, chloroplastic (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 10 member A8
Gene namesi
Name:ALDH10A8
Ordered Locus Names:At1g74920
ORF Names:F25A4.11, F9E10.23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G74920.

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. chloroplast Source: UniProtKB-SubCell
  3. cytosol Source: TAIR
  4. leucoplast Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 77ChloroplastSequence Analysis
Chaini8 – 501494Betaine aldehyde dehydrogenase 1, chloroplasticPRO_0000007179Add
BLAST

Proteomic databases

PaxDbiQ9S795.
PRIDEiQ9S795.

Expressioni

Gene expression databases

ExpressionAtlasiQ9S795. baseline and differential.
GenevestigatoriQ9S795.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9S795.
SMRiQ9S795. Positions 4-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9S795.
KOiK00130.
OMAiLSACFLN.
PhylomeDBiQ9S795.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9S795-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIPMPTRQL FIDGEWREPI LKKRIPIVNP ATEEVIGDIP AATTEDVDVA
60 70 80 90 100
VNAARRALSR NKGKDWAKAP GAVRAKYLRA IAAKVNERKT DLAKLEALDC
110 120 130 140 150
GKPLDEAVWD MDDVAGCFEF YADLAEGLDA KQKAPVSLPM ESFKSYVLKQ
160 170 180 190 200
PLGVVGLITP WNYPLLMAVW KVAPSLAAGC TAILKPSELA SVTCLELADI
210 220 230 240 250
CREVGLPPGV LNVLTGFGSE AGAPLASHPG VDKIAFTGSF ATGSKVMTAA
260 270 280 290 300
AQLVKPVSME LGGKSPLIVF DDVDLDKAAE WALFGCFWTN GQICSATSRL
310 320 330 340 350
LVHESIASEF IEKLVKWSKN IKISDPMEEG CRLGPVVSKG QYEKILKFIS
360 370 380 390 400
TAKSEGATIL HGGSRPEHLE KGFFIEPTII TDVTTSMQIW REEVFGPVLC
410 420 430 440 450
VKTFASEDEA IELANDSHYG LGAAVISNDT ERCDRISEAF EAGIVWINCS
460 470 480 490 500
QPCFTQAPWG GVKRSGFGRE LGEWGLDNYL SVKQVTLYTS NDPWGWYKSP

N
Length:501
Mass (Da):54,432
Last modified:May 1, 2000 - v1
Checksum:iBA8B03C28C22453B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55284.1.
AC013258 Genomic DNA. Translation: AAG51938.1.
CP002684 Genomic DNA. Translation: AEE35649.1.
AY093071 mRNA. Translation: AAM13070.1.
BT008872 mRNA. Translation: AAP68311.1.
AY087395 mRNA. Translation: AAM64944.1.
AK220905 mRNA. Translation: BAD94340.1.
PIRiH96778.
RefSeqiNP_565094.1. NM_106150.3. [Q9S795-1]
UniGeneiAt.26779.

Genome annotation databases

EnsemblPlantsiAT1G74920.1; AT1G74920.1; AT1G74920. [Q9S795-1]
GeneIDi843831.
KEGGiath:AT1G74920.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA. Translation: AAD55284.1.
AC013258 Genomic DNA. Translation: AAG51938.1.
CP002684 Genomic DNA. Translation: AEE35649.1.
AY093071 mRNA. Translation: AAM13070.1.
BT008872 mRNA. Translation: AAP68311.1.
AY087395 mRNA. Translation: AAM64944.1.
AK220905 mRNA. Translation: BAD94340.1.
PIRiH96778.
RefSeqiNP_565094.1. NM_106150.3. [Q9S795-1]
UniGeneiAt.26779.

3D structure databases

ProteinModelPortaliQ9S795.
SMRiQ9S795. Positions 4-500.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9S795.
PRIDEiQ9S795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G74920.1; AT1G74920.1; AT1G74920. [Q9S795-1]
GeneIDi843831.
KEGGiath:AT1G74920.

Organism-specific databases

TAIRiAT1G74920.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9S795.
KOiK00130.
OMAiLSACFLN.
PhylomeDBiQ9S795.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
BioCyciARA:AT1G74920-MONOMER.
ARA:GQT-15-MONOMER.
ReactomeiREACT_230585. Carnitine synthesis.

Gene expression databases

ExpressionAtlasiQ9S795. baseline and differential.
GenevestigatoriQ9S795.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-501.
    Strain: cv. Columbia.
  6. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiBADH1_ARATH
AccessioniPrimary (citable) accession number: Q9S795
Secondary accession number(s): Q56ZQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.