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Q9S795

- BADH1_ARATH

UniProt

Q9S795 - BADH1_ARATH

Protein

Betaine aldehyde dehydrogenase 1, chloroplastic

Gene

ALDH10A8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei162 – 1621Transition state stabilizerBy similarity
    Active sitei260 – 2601Proton acceptorPROSITE-ProRule annotation
    Active sitei294 – 2941NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi238 – 2436NADBy similarity

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
    2. response to salt stress Source: TAIR
    3. response to water deprivation Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciARA:AT1G74920-MONOMER.
    ARA:GQT-15-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Betaine aldehyde dehydrogenase 1, chloroplastic (EC:1.2.1.8)
    Short name:
    BADH
    Alternative name(s):
    Aldehyde dehydrogenase family 10 member A8
    Gene namesi
    Name:ALDH10A8
    Ordered Locus Names:At1g74920
    ORF Names:F25A4.11, F9E10.23
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G74920.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. chloroplast Source: UniProtKB-SubCell
    3. cytosol Source: TAIR
    4. leucoplast Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 77ChloroplastSequence Analysis
    Chaini8 – 501494Betaine aldehyde dehydrogenase 1, chloroplasticPRO_0000007179Add
    BLAST

    Proteomic databases

    PaxDbiQ9S795.
    PRIDEiQ9S795.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9S795.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S795.
    SMRiQ9S795. Positions 4-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    InParanoidiQ9S795.
    KOiK00130.
    OMAiRMIVPRN.
    PhylomeDBiQ9S795.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9S795-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIPMPTRQL FIDGEWREPI LKKRIPIVNP ATEEVIGDIP AATTEDVDVA    50
    VNAARRALSR NKGKDWAKAP GAVRAKYLRA IAAKVNERKT DLAKLEALDC 100
    GKPLDEAVWD MDDVAGCFEF YADLAEGLDA KQKAPVSLPM ESFKSYVLKQ 150
    PLGVVGLITP WNYPLLMAVW KVAPSLAAGC TAILKPSELA SVTCLELADI 200
    CREVGLPPGV LNVLTGFGSE AGAPLASHPG VDKIAFTGSF ATGSKVMTAA 250
    AQLVKPVSME LGGKSPLIVF DDVDLDKAAE WALFGCFWTN GQICSATSRL 300
    LVHESIASEF IEKLVKWSKN IKISDPMEEG CRLGPVVSKG QYEKILKFIS 350
    TAKSEGATIL HGGSRPEHLE KGFFIEPTII TDVTTSMQIW REEVFGPVLC 400
    VKTFASEDEA IELANDSHYG LGAAVISNDT ERCDRISEAF EAGIVWINCS 450
    QPCFTQAPWG GVKRSGFGRE LGEWGLDNYL SVKQVTLYTS NDPWGWYKSP 500
    N 501
    Length:501
    Mass (Da):54,432
    Last modified:May 1, 2000 - v1
    Checksum:iBA8B03C28C22453B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008263 Genomic DNA. Translation: AAD55284.1.
    AC013258 Genomic DNA. Translation: AAG51938.1.
    CP002684 Genomic DNA. Translation: AEE35649.1.
    AY093071 mRNA. Translation: AAM13070.1.
    BT008872 mRNA. Translation: AAP68311.1.
    AY087395 mRNA. Translation: AAM64944.1.
    AK220905 mRNA. Translation: BAD94340.1.
    PIRiH96778.
    RefSeqiNP_565094.1. NM_106150.3. [Q9S795-1]
    UniGeneiAt.26779.

    Genome annotation databases

    EnsemblPlantsiAT1G74920.1; AT1G74920.1; AT1G74920. [Q9S795-1]
    GeneIDi843831.
    KEGGiath:AT1G74920.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008263 Genomic DNA. Translation: AAD55284.1 .
    AC013258 Genomic DNA. Translation: AAG51938.1 .
    CP002684 Genomic DNA. Translation: AEE35649.1 .
    AY093071 mRNA. Translation: AAM13070.1 .
    BT008872 mRNA. Translation: AAP68311.1 .
    AY087395 mRNA. Translation: AAM64944.1 .
    AK220905 mRNA. Translation: BAD94340.1 .
    PIRi H96778.
    RefSeqi NP_565094.1. NM_106150.3. [Q9S795-1 ]
    UniGenei At.26779.

    3D structure databases

    ProteinModelPortali Q9S795.
    SMRi Q9S795. Positions 4-500.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9S795.
    PRIDEi Q9S795.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G74920.1 ; AT1G74920.1 ; AT1G74920 . [Q9S795-1 ]
    GeneIDi 843831.
    KEGGi ath:AT1G74920.

    Organism-specific databases

    TAIRi AT1G74920.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    InParanoidi Q9S795.
    KOi K00130.
    OMAi RMIVPRN.
    PhylomeDBi Q9S795.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci ARA:AT1G74920-MONOMER.
    ARA:GQT-15-MONOMER.

    Gene expression databases

    Genevestigatori Q9S795.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-501.
      Strain: cv. Columbia.
    6. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiBADH1_ARATH
    AccessioniPrimary (citable) accession number: Q9S795
    Secondary accession number(s): Q56ZQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3