Reviewed, UniProtKB/Swiss-Prot Q9S795 (BADH1_ARATH)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase 1, chloroplastic
      Short name=BADH
    EC=1.2.1.8
Alternative name(s):
    Aldehyde dehydrogenase family 10 member A8

Gene names

Name:	ALDH10A8
Ordered Locus Names:	At1g74920
ORF Names:	F9E10.23, F25A4.11

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from direct assay. Source: TAIR chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 7	7	Chloroplast Potential
	Chain	8 – 501	494	Betaine aldehyde dehydrogenase 1, chloroplastic		PRO_0000007179
Regions
	Nucleotide binding	238 – 243	6	NAD By similarity
Sites
	Active site	260	1	Proton acceptor By similarity
	Active site	294	1	Nucleophile By similarity
	Site	162	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S795-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BA8B03C28C22453B	FASTA	501	54,432
	10 20 30 40 50 60 MAIPMPTRQL FIDGEWREPI LKKRIPIVNP ATEEVIGDIP AATTEDVDVA VNAARRALSR 70 80 90 100 110 120 NKGKDWAKAP GAVRAKYLRA IAAKVNERKT DLAKLEALDC GKPLDEAVWD MDDVAGCFEF 130 140 150 160 170 180 YADLAEGLDA KQKAPVSLPM ESFKSYVLKQ PLGVVGLITP WNYPLLMAVW KVAPSLAAGC 190 200 210 220 230 240 TAILKPSELA SVTCLELADI CREVGLPPGV LNVLTGFGSE AGAPLASHPG VDKIAFTGSF 250 260 270 280 290 300 ATGSKVMTAA AQLVKPVSME LGGKSPLIVF DDVDLDKAAE WALFGCFWTN GQICSATSRL 310 320 330 340 350 360 LVHESIASEF IEKLVKWSKN IKISDPMEEG CRLGPVVSKG QYEKILKFIS TAKSEGATIL 370 380 390 400 410 420 HGGSRPEHLE KGFFIEPTII TDVTTSMQIW REEVFGPVLC VKTFASEDEA IELANDSHYG 430 440 450 460 470 480 LGAAVISNDT ERCDRISEAF EAGIVWINCS QPCFTQAPWG GVKRSGFGRE LGEWGLDNYL 490 500 SVKQVTLYTS NDPWGWYKSP N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-501. Strain: cv. Columbia.
[5]	"The ALDH gene superfamily of Arabidopsis." Kirch H.-H., Bartels D., Wei Y., Schnable P.S., Wood A.J. Trends Plant Sci. 9:371-377(2004) [PubMed: 15358267] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC013258 Genomic DNA. Translation: AAG51938.1. AC008263 Genomic DNA. Translation: AAD55284.1. AY093071 mRNA. Translation: AAM13070.1. BT008872 mRNA. Translation: AAP68311.1. AY087395 mRNA. Translation: AAM64944.1. AK220905 mRNA. Translation: BAD94340.1.
IPI	IPI00547056.
PIR	H96778.
RefSeq	NP_565094.1.
UniGene	At.26779
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9S795.
Proteomic databases
PRIDE	Q9S795.
Genome annotation databases
GeneID	843831.
GenomeReviews	Gene locus AT1G74920 in contig CT485782_GR.
KEGG	ath:AT1G74920.
NMPDR	fig|3702.1.peg.7008.
Organism-specific databases
TAIR	At1g74920.
Phylogenomic databases
eggNOG	KOG2450.
HOGENOM	HBG752218.
InParanoid	Q9S795.
OMA	KAVEWTL.
PhylomeDB	Q9S795.
Enzyme and pathway databases
BRENDA	1.2.1.8. 302.
Gene expression databases
ArrayExpress	Q9S795.
Genevestigator	Q9S795.
GermOnline	AT1G74920. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH1_ARATH

Accession

Primary (citable) accession number: Q9S795
Secondary accession number(s): Q56ZQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)