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Q9S756

- FRI4_ARATH

UniProt

Q9S756 - FRI4_ARATH

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Protein

Ferritin-4, chloroplastic

Gene

FER4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Iron 1PROSITE-ProRule annotation
Metal bindingi143 – 1431Iron 1PROSITE-ProRule annotation
Metal bindingi143 – 1431Iron 2PROSITE-ProRule annotation
Metal bindingi146 – 1461Iron 1PROSITE-ProRule annotation
Metal bindingi192 – 1921Iron 2PROSITE-ProRule annotation
Metal bindingi226 – 2261Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. flower development Source: TAIR
  3. iron ion homeostasis Source: TAIR
  4. iron ion transport Source: TAIR
  5. leaf development Source: TAIR
  6. photosynthesis Source: TAIR
  7. response to iron ion Source: TAIR
  8. response to reactive oxygen species Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G40300-MONOMER.
ReactomeiREACT_231148. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-4, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:FER4
Ordered Locus Names:At2g40300
ORF Names:T07M07.18, T3G21.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G40300.

Subcellular locationi

Plastidchloroplast By similarity

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast envelope Source: TAIR
  3. chloroplast stroma Source: TAIR
  4. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5757ChloroplastSequence AnalysisAdd
BLAST
Chaini58 – 259202Ferritin-4, chloroplasticPRO_0000008857Add
BLAST

Proteomic databases

PaxDbiQ9S756.
PRIDEiQ9S756.

Expressioni

Gene expression databases

GenevestigatoriQ9S756.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

BioGridi3960. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9S756.
SMRiQ9S756. Positions 67-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 244154Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 9033Extension peptide (EP)Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223383.
InParanoidiQ9S756.
KOiK00522.
OMAiESAHEER.
PhylomeDBiQ9S756.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S756-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLKTVSSSS SSALSLVNFH GVKKDVSPLL PSISSNLRVS SGKSGNLTFS
60 70 80 90 100
FRASKSSTTD ALSGVVFEPF KEVKKELDLV PTSSHLSLAR QKYSDECEAA
110 120 130 140 150
INEQINVEYN VSYVYHAMYA YFDRDNIALK GLAKFFKESS LEEREHAEKL
160 170 180 190 200
MEYQNKRGGR VKLQSIVMPL SEFEHVDKGD ALYGMELALS LEKLVNEKLL
210 220 230 240 250
NLHSVASKNN DVHLADFIES EFLTEQVEAI KLISEYVAQL RRVGKGHGTW

HFNQMLLEG
Length:259
Mass (Da):29,029
Last modified:May 1, 2000 - v1
Checksum:iCFEC3BA233BAAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312191 mRNA. Translation: CAC85400.1.
AF085279 Genomic DNA. Translation: AAD25945.1.
AC007020 Genomic DNA. Translation: AAD25665.1.
CP002685 Genomic DNA. Translation: AEC09810.1.
AY062795 mRNA. Translation: AAL32873.1.
AY081615 mRNA. Translation: AAM10177.1.
PIRiG84827.
RefSeqiNP_181559.1. NM_129588.4.
UniGeneiAt.27228.
At.69019.

Genome annotation databases

EnsemblPlantsiAT2G40300.1; AT2G40300.1; AT2G40300.
GeneIDi818622.
KEGGiath:AT2G40300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312191 mRNA. Translation: CAC85400.1 .
AF085279 Genomic DNA. Translation: AAD25945.1 .
AC007020 Genomic DNA. Translation: AAD25665.1 .
CP002685 Genomic DNA. Translation: AEC09810.1 .
AY062795 mRNA. Translation: AAL32873.1 .
AY081615 mRNA. Translation: AAM10177.1 .
PIRi G84827.
RefSeqi NP_181559.1. NM_129588.4.
UniGenei At.27228.
At.69019.

3D structure databases

ProteinModelPortali Q9S756.
SMRi Q9S756. Positions 67-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 3960. 1 interaction.

Proteomic databases

PaxDbi Q9S756.
PRIDEi Q9S756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G40300.1 ; AT2G40300.1 ; AT2G40300 .
GeneIDi 818622.
KEGGi ath:AT2G40300.

Organism-specific databases

TAIRi AT2G40300.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223383.
InParanoidi Q9S756.
KOi K00522.
OMAi ESAHEER.
PhylomeDBi Q9S756.

Enzyme and pathway databases

BioCyci ARA:AT2G40300-MONOMER.
Reactomei REACT_231148. Iron uptake and transport.

Gene expression databases

Genevestigatori Q9S756.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family."
    Petit J.-M., Briat J.-F., Lobreaux S.
    Biochem. J. 359:575-582(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07."
    Wang M.L., Belmonte S., Kim U., Dolan M., Morris J.W., Goodman H.M.
    Genome Res. 9:325-333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiFRI4_ARATH
AccessioniPrimary (citable) accession number: Q9S756
Secondary accession number(s): Q8WHW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3