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Protein

Ferritin-4, chloroplastic

Gene

FER4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108Iron 1PROSITE-ProRule annotation1
Metal bindingi143Iron 1PROSITE-ProRule annotation1
Metal bindingi143Iron 2PROSITE-ProRule annotation1
Metal bindingi146Iron 1PROSITE-ProRule annotation1
Metal bindingi192Iron 2PROSITE-ProRule annotation1
Metal bindingi226Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • flower development Source: TAIR
  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion homeostasis Source: TAIR
  • iron ion transport Source: TAIR
  • leaf development Source: TAIR
  • photosynthesis Source: TAIR
  • response to iron ion Source: TAIR
  • response to reactive oxygen species Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G40300-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-4, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:FER4
Ordered Locus Names:At2g40300
ORF Names:T07M07.18, T3G21.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G40300
TAIRilocus:2063104 AT2G40300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 57ChloroplastSequence analysisAdd BLAST57
ChainiPRO_000000885758 – 259Ferritin-4, chloroplasticAdd BLAST202

Proteomic databases

PaxDbiQ9S756

Expressioni

Gene expression databases

ExpressionAtlasiQ9S756 baseline and differential
GenevisibleiQ9S756 AT

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

BioGridi3960, 1 interactor
STRINGi3702.AT2G40300.1

Structurei

3D structure databases

ProteinModelPortaliQ9S756
SMRiQ9S756
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 244Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 90Extension peptide (EP)Add BLAST33

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
InParanoidiQ9S756
KOiK00522
OMAiQALHNFA
OrthoDBiEOG09360PX4
PhylomeDBiQ9S756

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9S756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKTVSSSS SSALSLVNFH GVKKDVSPLL PSISSNLRVS SGKSGNLTFS
60 70 80 90 100
FRASKSSTTD ALSGVVFEPF KEVKKELDLV PTSSHLSLAR QKYSDECEAA
110 120 130 140 150
INEQINVEYN VSYVYHAMYA YFDRDNIALK GLAKFFKESS LEEREHAEKL
160 170 180 190 200
MEYQNKRGGR VKLQSIVMPL SEFEHVDKGD ALYGMELALS LEKLVNEKLL
210 220 230 240 250
NLHSVASKNN DVHLADFIES EFLTEQVEAI KLISEYVAQL RRVGKGHGTW

HFNQMLLEG
Length:259
Mass (Da):29,029
Last modified:May 1, 2000 - v1
Checksum:iCFEC3BA233BAAAA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312191 mRNA Translation: CAC85400.1
AF085279 Genomic DNA Translation: AAD25945.1
AC007020 Genomic DNA Translation: AAD25665.1
CP002685 Genomic DNA Translation: AEC09810.1
AY062795 mRNA Translation: AAL32873.1
AY081615 mRNA Translation: AAM10177.1
PIRiG84827
RefSeqiNP_181559.1, NM_129588.5
UniGeneiAt.27228
At.69019

Genome annotation databases

EnsemblPlantsiAT2G40300.1; AT2G40300.1; AT2G40300
GeneIDi818622
GrameneiAT2G40300.1; AT2G40300.1; AT2G40300
KEGGiath:AT2G40300

Similar proteinsi

Entry informationi

Entry nameiFRI4_ARATH
AccessioniPrimary (citable) accession number: Q9S756
Secondary accession number(s): Q8WHW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health