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Q9S756

- FRI4_ARATH

UniProt

Q9S756 - FRI4_ARATH

Protein

Ferritin-4, chloroplastic

Gene

FER4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi108 – 1081Iron 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Iron 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Iron 2PROSITE-ProRule annotation
    Metal bindingi146 – 1461Iron 1PROSITE-ProRule annotation
    Metal bindingi192 – 1921Iron 2PROSITE-ProRule annotation
    Metal bindingi226 – 2261Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. flower development Source: TAIR
    3. iron ion homeostasis Source: TAIR
    4. iron ion transport Source: TAIR
    5. leaf development Source: TAIR
    6. photosynthesis Source: TAIR
    7. response to iron ion Source: TAIR
    8. response to reactive oxygen species Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G40300-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-4, chloroplastic (EC:1.16.3.1)
    Gene namesi
    Name:FER4
    Ordered Locus Names:At2g40300
    ORF Names:T07M07.18, T3G21.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G40300.

    Subcellular locationi

    Plastidchloroplast By similarity

    GO - Cellular componenti

    1. chloroplast Source: TAIR
    2. chloroplast envelope Source: TAIR
    3. chloroplast stroma Source: TAIR
    4. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5757ChloroplastSequence AnalysisAdd
    BLAST
    Chaini58 – 259202Ferritin-4, chloroplasticPRO_0000008857Add
    BLAST

    Proteomic databases

    PaxDbiQ9S756.
    PRIDEiQ9S756.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9S756.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.By similarity

    Protein-protein interaction databases

    BioGridi3960. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S756.
    SMRiQ9S756. Positions 67-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 244154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 9033Extension peptide (EP)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223383.
    InParanoidiQ9S756.
    KOiK00522.
    OMAiESAHEER.
    PhylomeDBiQ9S756.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9S756-1 [UniParc]FASTAAdd to Basket

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    MLLKTVSSSS SSALSLVNFH GVKKDVSPLL PSISSNLRVS SGKSGNLTFS    50
    FRASKSSTTD ALSGVVFEPF KEVKKELDLV PTSSHLSLAR QKYSDECEAA 100
    INEQINVEYN VSYVYHAMYA YFDRDNIALK GLAKFFKESS LEEREHAEKL 150
    MEYQNKRGGR VKLQSIVMPL SEFEHVDKGD ALYGMELALS LEKLVNEKLL 200
    NLHSVASKNN DVHLADFIES EFLTEQVEAI KLISEYVAQL RRVGKGHGTW 250
    HFNQMLLEG 259
    Length:259
    Mass (Da):29,029
    Last modified:May 1, 2000 - v1
    Checksum:iCFEC3BA233BAAAA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312191 mRNA. Translation: CAC85400.1.
    AF085279 Genomic DNA. Translation: AAD25945.1.
    AC007020 Genomic DNA. Translation: AAD25665.1.
    CP002685 Genomic DNA. Translation: AEC09810.1.
    AY062795 mRNA. Translation: AAL32873.1.
    AY081615 mRNA. Translation: AAM10177.1.
    PIRiG84827.
    RefSeqiNP_181559.1. NM_129588.4.
    UniGeneiAt.27228.
    At.69019.

    Genome annotation databases

    EnsemblPlantsiAT2G40300.1; AT2G40300.1; AT2G40300.
    GeneIDi818622.
    KEGGiath:AT2G40300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312191 mRNA. Translation: CAC85400.1 .
    AF085279 Genomic DNA. Translation: AAD25945.1 .
    AC007020 Genomic DNA. Translation: AAD25665.1 .
    CP002685 Genomic DNA. Translation: AEC09810.1 .
    AY062795 mRNA. Translation: AAL32873.1 .
    AY081615 mRNA. Translation: AAM10177.1 .
    PIRi G84827.
    RefSeqi NP_181559.1. NM_129588.4.
    UniGenei At.27228.
    At.69019.

    3D structure databases

    ProteinModelPortali Q9S756.
    SMRi Q9S756. Positions 67-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 3960. 1 interaction.

    Proteomic databases

    PaxDbi Q9S756.
    PRIDEi Q9S756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G40300.1 ; AT2G40300.1 ; AT2G40300 .
    GeneIDi 818622.
    KEGGi ath:AT2G40300.

    Organism-specific databases

    TAIRi AT2G40300.

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223383.
    InParanoidi Q9S756.
    KOi K00522.
    OMAi ESAHEER.
    PhylomeDBi Q9S756.

    Enzyme and pathway databases

    BioCyci ARA:AT2G40300-MONOMER.

    Gene expression databases

    Genevestigatori Q9S756.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family."
      Petit J.-M., Briat J.-F., Lobreaux S.
      Biochem. J. 359:575-582(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07."
      Wang M.L., Belmonte S., Kim U., Dolan M., Morris J.W., Goodman H.M.
      Genome Res. 9:325-333(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiFRI4_ARATH
    AccessioniPrimary (citable) accession number: Q9S756
    Secondary accession number(s): Q8WHW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3