Reviewed, UniProtKB/Swiss-Prot Q9S469 (ARAD_BACST)

Names and origin

Protein names

Recommended name:
    L-ribulose-5-phosphate 4-epimerase
    EC=5.1.3.4
Alternative name(s):
    Phosphoribulose isomerase

Gene names

Name:

araD

Organism

Bacillus stearothermophilus (Geobacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-ribulose 5-phosphate = D-xylulose 5-phosphate.
Cofactor	Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.
Sequence similarities	Belongs to the aldolase class II family. AraD/fucA subfamily.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	L-arabinose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	L-ribulose-phosphate 4-epimerase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	L-ribulose-5-phosphate 4-epimerase		PRO_0000162917
Sites
	Metal binding	75	1	Zinc By similarity
	Metal binding	94	1	Zinc By similarity
	Metal binding	96	1	Zinc By similarity
	Metal binding	168	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S469-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 66EEC1746D950C84	FASTA	228	25,227
	10 20 30 40 50 60 MLEELKQAVL EANLQLPQYR LVTFTWGNVS GIDRERGLVV IKPSGVAYDK LTIDDMVVVD 70 80 90 100 110 120 LTGNVVEGDL KPSSDTPTHL WLYKQFPGIG GIVHTHSTWA TVWAQAGKGI PALGTTHADY 130 140 150 160 170 180 FYGEIPCTRP MTNEEIQGAY ELETGKVITE TFRFLDPLQM PGVLVHGHGP FAWGKDPANA 190 200 210 220 VHNAVVLEEV AKMAARTYML NPNAKPISQT LLDRHYLRKH GANAYYGQ

References

[1]	"The L-arabinose utilization gene cluster from Bacillus stearothermophilus T-6." Gilead-Gropper S., Shoham Y. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T-6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF160811 Genomic DNA. Translation: AAD45716.1.
3D structure databases
HSSP	HSSP built from PDB template 1JDI based on UniProtKB P08203.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.1.3.4. 266715.
Family and domain databases
InterPro	IPR001303. Aldolase_II/adducin_N. IPR004661. AraD. [Graphical view]
Gene3D	G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
TIGRFAMs	TIGR00760. araD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAD_BACST

Accession

Primary (citable) accession number: Q9S469

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	May 1, 2000
Last modified:	September 22, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)