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Protein
Submitted name:

Protein-tyrosine-phosphatase

Gene

PPI

Organism
Shewanella sp.
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Calcium 1Combined sources
Metal bindingi97 – 971Zinc 1Combined sources
Metal bindingi99 – 991Calcium 1; via tele nitrogenCombined sources
Metal bindingi99 – 991Zinc 1; via tele nitrogenCombined sources
Metal bindingi133 – 1331Calcium 1Combined sources
Metal bindingi133 – 1331Calcium 2Combined sources
Metal bindingi133 – 1331Zinc 1Combined sources
Metal bindingi133 – 1331Zinc 2Combined sources
Metal bindingi168 – 1681Calcium 2Combined sources
Metal bindingi168 – 1681Zinc 2Combined sources
Metal bindingi226 – 2261Calcium 2; via tele nitrogenCombined sources
Metal bindingi226 – 2261Zinc 2; via tele nitrogenCombined sources
Metal bindingi305 – 3051Calcium 2; via pros nitrogenCombined sources
Metal bindingi305 – 3051Zinc 2; via pros nitrogenCombined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Protein family/group databases

PptaseDBiP3D0411150.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein-tyrosine-phosphataseImported (EC:3.1.3.48Imported)
Gene namesi
Name:PPIImported
OrganismiShewanella sp.Imported
Taxonomic identifieri50422 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Pathology & Biotechi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 66Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZBMX-ray1.50A22-355[»]
ProteinModelPortaliQ9S427.
SMRiQ9S427. Positions 25-355.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9S427.

Family & Domainsi

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S427-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIYCLAVL SLTLLSPLAL ANTATEFDGP YVITPISGQS TAYWICDNRL
60 70 80 90 100
KTTSIEKLQV NRPEHCGDLP ETKLSSEIKQ IMPDTYLGIK KVVALSDVHG
110 120 130 140 150
QYDVLLTLLK KQKIIDSDGN WAFGEGHMVM TGDIFDRGHQ VNEVLWFMYQ
160 170 180 190 200
LDQQARDAGG MVHLLMGNHE QMVLGGDLRY VHQRYDIATT LINRPYNKLY
210 220 230 240 250
GADTEIGQWL RSKNTIIKIN DVLYMHGGIS SEWISRELTL DKANALYRAN
260 270 280 290 300
VDASKKSLKA DDLLNFLFFG NGPTWYRGYF SETFTEAELD TILQHFNVNH
310 320 330 340 350
IVVGHTSQER VLGLFHNKVI AVDSSIKVGK SGELLLLENN RLIRGLYDGT
360
RETLQENSLN Q
Length:361
Mass (Da):40,815
Last modified:May 1, 2000 - v1
Checksum:iD44CF9FC13D08039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164202 Genomic DNA. Translation: AAD45611.1.
PIRiJC7171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164202 Genomic DNA. Translation: AAD45611.1.
PIRiJC7171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZBMX-ray1.50A22-355[»]
ProteinModelPortaliQ9S427.
SMRiQ9S427. Positions 25-355.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB05260. Gallium nitrate.

Protein family/group databases

PptaseDBiP3D0411150.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ9S427.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of phosphatase I gene from a psychrophile, Shewanella sp., and some properties of the recombinant enzyme."
    Tsuruta H., Aizono Y.
    J. Biochem. 127:143-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The role of group bulkiness in the catalytic activity of psychrophile cold-active protein tyrosine phosphatase."
    Tsuruta H., Mikami B., Yamamoto C., Yamagata H.
    FEBS J. 275:4317-4328(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 22-361 IN COMPLEX WITH ZINC, ACTIVE SITE.

Entry informationi

Entry nameiQ9S427_9GAMM
AccessioniPrimary (citable) accession number: Q9S427
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.